Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Carole R. Rickards"'
Autor:
Daniel Cochrane, Gavin William Grahame Wilkinson, Peter Tomasec, James A. Davies, Richard J. Stanton, Melanie Moore, Carole R. Rickards, Virginie Prod'homme, Akio Nomoto, Daniel Sugrue
Publikováno v:
The Journal of General Virology
Human cytomegalovirus (HCMV) UL141 induces protection against natural killer cell-mediated cytolysis by downregulating cell surface expression of CD155 (nectin-like molecule 5; poliovirus receptor), a ligand for the activating receptor DNAM-1 (CD226)
Autor:
Edward Chung Yern Wang, Andrew J. Davison, Cora Griffin, Melanie Armstrong, Peter Tomasec, Richard J. Stanton, Brian P. McSharry, Rebecca Aicheler, Virginie Prod'homme, Sian Llewellyn-Lacey, Daniel Cochrane, Carole R. Rickards, Gavin William Grahame Wilkinson
Publikováno v:
Journal of Clinical Virology. 41:206-212
Human cytomegalovirus (HCMV) causes lifelong, persistent infections and its survival is under intense, continuous selective pressure from the immune system. A key aspect of HCMV’s capacity for survival lies in immune avoidance. In this context, cel
Autor:
Richard J. Stanton, Carole R. Rickards, Gavin William Grahame Wilkinson, Peter Tomasec, Rebecca Aicheler, Virginie Prod'homme, Leszek K. Borysiewicz, Cora Griffin, Miguel López-Botet, Brian P. McSharry, Edward Chung Yern Wang
Publikováno v:
The Journal of Immunology. 178:4473-4481
The inhibitory leukocyte Ig-like receptor 1 (LIR-1, also known as ILT2, CD85j, or LILRB1) was identified by its high affinity for the human CMV (HCMV) MHC class I homolog gpUL18. The role of this LIR-1-gpUL18 interaction in modulating NK recognition
Publikováno v:
Journal of General Virology. 79:1233-1245
The PML gene product is associated with a defined nuclear structure (10-20 per cell) known variously as PML-bodies, ND10, PODs or Kr bodies. Certain conditions are known to compromise the integrity of PML-bodies; these include environmental stress (e
Autor:
Andrew J. McMichael, Carole R. Rickards, Martin B. Powell, Veronique M. Braud, Peter Tomasec, Vincenzo Cerundolo, Stephan D. Gadola, Gavin William Grahame Wilkinson, Leszek K. Borysiewicz, Brian P. McSharry
Publikováno v:
Science. 287:1031-1033
The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits natural killer (NK) cell–mediated lysis by interacting with CD94/NKG2A receptors. Surface expression of HLA-E depends on binding of conserved peptides derived f
Autor:
Richard J. Stanton, Edward Chung Yern Wang, Peter Tomasec, Gavin William Grahame Wilkinson, Carole R. Rickards, Brian P. McSharry
Human cytomegalovirus (HCMV) systematically manages the expression of cellular functions, rather than exerting the global shutoff of host cell protein synthesis commonly observed with other herpesviruses during the lytic cycle. While microarray techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80460517d0d54ac0198a5919759e2766
Autor:
Peter Tomasec, Cora Griffin, Edward Chung Yern Wang, Brian P. McSharry, Gavin William Grahame Wilkinson, Carole R. Rickards, Helena Browne
Human cytomegalovirus (HCMV) gpUL18 is a HLA class I (HLA-I) homologue with high affinity for the inhibitory receptor LIR-1/ILT2. The previously described 67 kDa form of gpUL18 is shown here to be sensitive to endoglycosidase-H (EndoH). A novel form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba1c80c0ac0032fe956f2837ed36d82
https://europepmc.org/articles/PMC2844262/
https://europepmc.org/articles/PMC2844262/
Autor:
Peter Tomasec, Gavin William Grahame Wilkinson, Akio Nomoto, Sian Llewellyn-Lacey, Edward Chung Yern Wang, Borivoj Vojtesek, Melanie Armstrong, Andrew J. Davison, Carole R. Rickards, Brian P. McSharry, Rebecca J. Morris, Cora Griffin, Christian Sinzger
Publikováno v:
Nature immunology. 6(2)
Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegaloviru
In essence, replication-deficient (RD) adenovirus (Ad) vectors can be considered to function as an extremely efficient DNA transfection system capable of providing transgene expression in up to 100% of cells both in vitro or in vivo. As researchers c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92d7c0dcc1a80a126a3f532832bdf692
https://doi.org/10.1385/0-89603-521-2:539
https://doi.org/10.1385/0-89603-521-2:539
Publikováno v:
Neuroscience Letters. 129:262-264
Somatostatin (SRIF) release from fetal rat cortical cells was stimulated by exposure to 10−5 M N- methyl- d -aspartate (NMDA) (250 ± 20% of basal at 96 h). A similar but much less potent effect was seen with kainate (KA) but not with quisqualate (