Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Carole Pissot-Soldermann"'
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 841K, Supplementary Figures S1-S6; legends for Supplementary Tables S1-S3; Supplementary Methods describing RNA interference, generation of Ba/F3 cell lines, site-directed mutagenesis, transient transfection, inhibition of cellular ATP pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d1c96f82771189e532e391627afa78
https://doi.org/10.1158/2159-8290.22528301.v1
https://doi.org/10.1158/2159-8290.22528301.v1
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 11K, Activity of NVP-BBT594 in biochemical and cell-based assays. The IC50 (mean of two experiments) of NVP-BBT594 on the JAK2 kinase was determined in a biochemical kinase assay with the active enzyme. Half-maximal growth inhibition (GI50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31418f731a67ae71f974979b4eddf70
https://doi.org/10.1158/2159-8290.22528298
https://doi.org/10.1158/2159-8290.22528298
Autor:
Thomas Radimerski, Francesco Hofmann, Lorenza Wyder, Markus Wartmann, Eric Vangrevelinghe, Joerg Trappe, Stephan Ruetz, Lynda Nolan, David Ledieu, Marc Lang, Marc Gerspacher, Pascal Furet, Dirk Erdmann, Peter Drueckes, Patrick Chène, Josef Brueggen, Francesca Blasco, Gisele A. Tavares, Carole Pissot-Soldermann, Alain De Pover, Catherine H. Régnier, Fabienne Baffert
The recent discovery of an acquired activating point mutation in JAK2, substituting valine at amino acid position 617 for phenylalanine, has greatly improved our understanding of the molecular mechanism underlying chronic myeloproliferative neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7997e164cd9af3cf9ffb6c692aca1cec
https://doi.org/10.1158/1535-7163.c.6531816
https://doi.org/10.1158/1535-7163.c.6531816
Autor:
Thomas Radimerski, Francesco Hofmann, Lorenza Wyder, Markus Wartmann, Eric Vangrevelinghe, Joerg Trappe, Stephan Ruetz, Lynda Nolan, David Ledieu, Marc Lang, Marc Gerspacher, Pascal Furet, Dirk Erdmann, Peter Drueckes, Patrick Chène, Josef Brueggen, Francesca Blasco, Gisele A. Tavares, Carole Pissot-Soldermann, Alain De Pover, Catherine H. Régnier, Fabienne Baffert
Supplementary Data from Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9b8ce3cdd08cb9653d9038e050b02d
https://doi.org/10.1158/1535-7163.22485180.v1
https://doi.org/10.1158/1535-7163.22485180.v1
Autor:
Ying Huang, Martin Sendzik, Jeff Zhang, Zhenting Gao, Yongfeng Sun, Long Wang, Justin Gu, Kehao Zhao, Zhengtian Yu, Lijun Zhang, Qiong Zhang, Joachim Blanz, Zijun Chen, Valérie Dubost, Douglas Fang, Lijian Feng, Xingnian Fu, Michael Kiffe, Ling Li, Fangjun Luo, Xiao Luo, Yuan Mi, Prakash Mistry, David Pearson, Alessandro Piaia, Clemens Scheufler, Remi Terranova, Andreas Weiss, Jue Zeng, Hailong Zhang, Jiangwei Zhang, Mengxi Zhao, Michael P. Dillon, Sebastien Jeay, Wei Qi, Jonathan Moggs, Carole Pissot-Soldermann, En Li, Peter Atadja, Andreas Lingel, Counde Oyang
Publikováno v:
Journal of Medicinal Chemistry. 65:5317-5333
Polycomb Repressive Complex 2 (PRC2) plays an important role in transcriptional regulation during animal development and in cell differentiation, and alteration of PRC2 activity has been associated with cancer. On a molecular level, PRC2 catalyzes me
Autor:
Upendra Argikar, Markus Blatter, Dallas Bednarczyk, Zhuoliang Chen, Young Shin Cho, Michaël Doré, Jennifer L. Dumouchel, Samuel Ho, Klemens Hoegenauer, Toshio Kawanami, Simon Mathieu, Erik Meredith, Henrik Möbitz, Stephen K. Murphy, Saravanan Parthasarathy, Carole Pissot Soldermann, Jobette Santos, Serena Silver, Suzanne Skolnik, Aleksandar Stojanovic
Publikováno v:
Journal of medicinal chemistry. 65(18)
An imidazolone → triazolone replacement addressed the limited passive permeability of a series of protein arginine methyl transferase 5 (PRMT5) inhibitors. This increase in passive permeability was unexpected given the increase in the hydrogen bond
Autor:
Marc Bigaud, Achim Schlapbach, Ina Dix, Ralf Endres, Jean Quancard, Jutta Blank, Frédéric Bornancin, Markus Wartmann, Julien Scesa, Paulo Antonio Fernandes Gomes Dos Santos, Eva Altmann, Thomas Radimerski, Guido Bold, Nicole Buschmann, Samu Melkko, Andreas Weiss, Paul W. Manley, P. Erbel, Oliver Simic, Thomas Zoller, Catherine H. Régnier, Ansgar Schuffenhauer, Elisabeth Buchdunger, Martin Renatus, Paul M.J. McSheehy, Carole Pissot Soldermann
Publikováno v:
Journal of Medicinal Chemistry. 63:14576-14593
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Autor:
Jean Quancard, Laurence Kieffer, Samu Melkko, Ralf Endres, Martin Renatus, Catherine H. Régnier, Thomas Calzascia, Mickael Sorge, Markus Wartmann, Frédéric Bornancin, Thomas Radimerski, P. Erbel, Carole Pissot Soldermann, Paul M.J. McSheehy, Markus Blatter, Reiner Aichholz, Trixie Wagner, Oliver Simic, Karen Beltz, Marc Bigaud, Achim Schlapbach, Andreas Weiss
Publikováno v:
Journal of Medicinal Chemistry. 63:14594-14608
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report
Autor:
Carole, Pissot Soldermann, Oliver, Simic, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Markus, Wartmann, Marc, Bigaud, Andreas, Weiss, Paul, McSheehy, Ralf, Endres, Paulo, Santos, Jutta, Blank, Ansgar, Schuffenhauer, Guido, Bold, Nicole, Buschmann, Thomas, Zoller, Eva, Altmann, Paul W, Manley, Ina, Dix, Elisabeth, Buchdunger, Julien, Scesa, Jean, Quancard, Achim, Schlapbach, Frédéric, Bornancin, Thomas, Radimerski, Catherine H, Régnier
Publikováno v:
Journal of medicinal chemistry. 63(23)
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Autor:
Jean, Quancard, Oliver, Simic, Carole, Pissot Soldermann, Reiner, Aichholz, Markus, Blatter, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Ralf, Endres, Mickael, Sorge, Laurence, Kieffer, Trixie, Wagner, Karen, Beltz, Paul, Mcsheehy, Markus, Wartmann, Catherine H, Régnier, Thomas, Calzascia, Thomas, Radimerski, Marc, Bigaud, Andreas, Weiss, Frédéric, Bornancin, Achim, Schlapbach
Publikováno v:
Journal of medicinal chemistry. 63(23)
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report