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pro vyhledávání: '"Carole Pissot-Solderman"'
Autor:
Tobias Gabriel, Thérèse Valat, Frédéric Baysang, Joerg Kallen, Philipp Holzer, Carole Pissot-Solderman, Pascal Furet, Keiichi Masuya, Sébastien Jeay, Patrick Chène, Geneviève Albrecht, Francesco Hofmann, Dirk Erdmann, Stefan Stutz, François Gessier, Nicole Buschmann
Publikováno v:
Cancer Research. 74:1798-1798
An effective strategy to restore p53 activity in cancer cells containing wild type p53 is to inhibit the Mdm2-p53 protein-protein interaction (PPI). NVP-CGM097 is a novel PPI inhibitor under evaluation in a Phase I clinical trial. It binds to the p53