Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Carole Long"'
Autor:
Ragavan Varadharajan Suresh, Bingbing Deng, Yonas Gebremicale, Kyle Roche, Kazutoyo Miura, Carole Long
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTPlasmodium falciparum is a parasite that causes the deadly human disease, malaria, and exhibits a complex life cycle in human and mosquito hosts. In the sexual stages of the parasite, gametocytes mature in the human body and propagate malaria
Externí odkaz:
https://doaj.org/article/c2a1dbe8f4c14544b3e82d666003c97b
Autor:
Wei-Chiao Huang, Moustafa T. Mabrouk, Luwen Zhou, Minami Baba, Mayumi Tachibana, Motomi Torii, Eizo Takashima, Emily Locke, Jordan Plieskatt, C. Richter King, Camila H. Coelho, Patrick E. Duffy, Carole Long, Takafumi Tsuboi, Kazutoyo Miura, Yimin Wu, Tomoko Ishino, Jonathan F. Lovell
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Co-display of two P. falciparum malaria vaccine antigens (Pfs230D1+ and CSP) on the surface of immunogenic liposomes results in functional immune responses upon immunization of mice and rabbits. Combining both antigens produces immune responses that
Externí odkaz:
https://doaj.org/article/f8e6b970eebc47eab359d0eb8d1b356e
Autor:
Wei-Chiao Huang, Bingbing Deng, Moustafa T. Mabrouk, Amal Seffouh, Joaquin Ortega, Carole Long, Kazutoyo Miura, Yimin Wu, Jonathan F. Lovell
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-12 (2020)
Abstract Background The Plasmodium falciparum sexual-stage surface proteins Pfs25 and Pfs230 are antigen candidates for a malaria transmission-blocking vaccine (TBV), and have been widely investigated as such. It is not clear whether simultaneously p
Externí odkaz:
https://doaj.org/article/53505351d4854109a223735264100c34
Autor:
Myriam Arévalo-Herrera, Kazutoyo Miura, Nora Cespedes, Carlos Echeverry, Eduardo Solano, Angélica Castellanos, Juan Sebastián Ramirez, Adolfo Miranda, Andrey V. Kajava, Carole Long, Giampietro Corradin, Sócrates Herrera
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
P48/45 is a conserved gametocyte antigen involved in Plasmodium parasite fertilization. A recombinant Plasmodium vivax P48/45 (Pvs48/45) protein expressed in Escherichia coli (E. coli) was highly antigenic and immunogenic in experimental animals and
Externí odkaz:
https://doaj.org/article/493a8e3aadac4edb995599fb31e64b3b
Autor:
Sanjai Kumar, Hong Zheng, Bingbing Deng, Babita Mahajan, Bryan Grabias, Yukiko Kozakai, Merribeth J Morin, Emily Locke, Ashley Birkett, Kazutoyo Miura, Carole Long
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115807 (2014)
There is still a need for sensitive and reproducible immunoassays for quantitative detection of malarial antigens in preclinical and clinical phases of vaccine development and in epidemiology and surveillance studies, particularly in the vector host.
Externí odkaz:
https://doaj.org/article/f42db41525b94c759a55ef27a9bb3642
Autor:
Ruth D Ellis, Yimin Wu, Laura B Martin, Donna Shaffer, Kazutoyo Miura, Joan Aebig, Andrew Orcutt, Kelly Rausch, Daming Zhu, Anders Mogensen, Michael P Fay, David L Narum, Carole Long, Louis Miller, Anna P Durbin
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46094 (2012)
A Phase 1 dose escalating study was conducted in malaria naïve adults to assess the safety, reactogenicity, and immunogenicity of the blood stage malaria vaccine BSAM2/Alhydrogel®+ CPG 7909. BSAM2 is a combination of the FVO and 3D7 alleles of reco
Externí odkaz:
https://doaj.org/article/08b261c51ad94288869cff2c341fcb56
Autor:
James S McCarthy, Joanne Marjason, Suzanne Elliott, Paul Fahey, Gilles Bang, Elissa Malkin, Eveline Tierney, Hayley Aked-Hurditch, Christopher Adda, Nadia Cross, Jack S Richards, Freya J I Fowkes, Michelle J Boyle, Carole Long, Pierre Druilhe, James G Beeson, Robin F Anders
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24413 (2011)
In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2), parasite densities in children were reduced by 62%. However, breakthrough parasitemias were disproportionately
Externí odkaz:
https://doaj.org/article/48362a580ee849fd841b7e69abb62ab8
Autor:
Kiprotich Chelimo, Paula B Embury, Peter Odada Sumba, John Vulule, Ayub V Ofulla, Carole Long, James W Kazura, Ann M Moormann
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24852 (2011)
Naturally acquired immunity to Plasmodium falciparum malaria in malaria holoendemic areas is characterized by the gradual, age-related development of protection against high-density parasitemia and clinical malaria. Animal studies, and less commonly,
Externí odkaz:
https://doaj.org/article/90c5bfc464da4015bd5ccfcdd9188b6c
Autor:
Michele D Spring, James F Cummings, Christian F Ockenhouse, Sheetij Dutta, Randall Reidler, Evelina Angov, Elke Bergmann-Leitner, V Ann Stewart, Stacey Bittner, Laure Juompan, Mark G Kortepeter, Robin Nielsen, Urszula Krzych, Ev Tierney, Lisa A Ware, Megan Dowler, Cornelus C Hermsen, Robert W Sauerwein, Sake J de Vlas, Opokua Ofori-Anyinam, David E Lanar, Jack L Williams, Kent E Kester, Kathryn Tucker, Meng Shi, Elissa Malkin, Carole Long, Carter L Diggs, Lorraine Soisson, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, D Gray Heppner
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5254 (2009)
This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein apical membrane antigen-1 (AMA-1) representing the 3D7 allele formulated with eithe
Externí odkaz:
https://doaj.org/article/3a664d9efe974ec3ad3412a3ecd03c9c
Autor:
Yimin Wu, Ruth D Ellis, Donna Shaffer, Erica Fontes, Elissa M Malkin, Siddhartha Mahanty, Michael P Fay, David Narum, Kelly Rausch, Aaron P Miles, Joan Aebig, Andrew Orcutt, Olga Muratova, Guanhong Song, Lynn Lambert, Daming Zhu, Kazutoyo Miura, Carole Long, Allan Saul, Louis H Miller, Anna P Durbin
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2636 (2008)
BackgroundPfs25 and Pvs25, surface proteins of mosquito stage of the malaria parasites P. falciparum and P. vivax, respectively, are leading candidates for vaccines preventing malaria transmission by mosquitoes. This single blinded, dose escalating,
Externí odkaz:
https://doaj.org/article/505909db3b03441eaf9a36aa2240a11a