Výsledky vyhledávání - "Carole I. Bradt"

Selection of low frequency tumor cells from cell culture by growth in nude mice

Autor: Carole I. Bradt, Sidney M. Hopfer, F.W. Sunderman, Warren W. Nichols, Matthews O. Bradley, Rosina Hill, Andrew R. Kraynak

Publikováno v: Cancer Genetics and Cytogenetics. 53:57-66

Tissue cultures of tumor cells are frequently utilized to characterize chromosomal changes when direct cytogenetic preparations on tumors fail. The present study demonstrates that chromosomal markers found in direct tumor preparations can become unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d63cf9cd59091c6f267025f6050c9b
https://doi.org/10.1016/0165-4608(91)90114-a

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Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53

Autor: Catherine A. Hilliard, Carole I. Bradt, Rosina B. Hill, Timothy E. Johnson, Michael J. Armstrong, Sheila M. Galloway, Susan K. Greenwood

Publikováno v: Mutation research. 401(1-2)

The human lymphoblastoid cell lines TK6 (normal p53) and WI-L2-NS or WTK1 (mutant p53) differ in sensitivity to killing and induction of gene mutations and chromosome aberrations by ionizing radiation. This may be related to decreased apoptosis in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11baa565417a1736836c253feb4e7a23
https://pubmed.ncbi.nlm.nih.gov/9639670

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Chromosome aberrations: persistence of alkylation damage and modulation by O6-alkylguanine-DNA alkyltransferase

Autor: Rosina B. Hill, Christian L. Bean, Timothy E. Johnson, Sheila M. Galloway, Michelle Stallworth, Carole I. Bradt

Publikováno v: Mutation research. 307(1)

Alkylating agents produce a spectrum of DNA lesions alkylated at different sites on the molecule. These lesions differ in their propensities to cause effects such as cytotoxicity, mutations and sister-chromatid exchanges. We have used our observation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89417546537b3c83ddcebce52106d849
https://pubmed.ncbi.nlm.nih.gov/7513826

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Skin fibroblasts from aged Fischer 344 rats undergo similar changes in replicative life span but not immortalization with caloric restriction of donors

Autor: Warren W. Nichols, Edward J. Masoro, Carole I. Bradt, Robert J. Pignolo, Vincent J. Cristofalo

Publikováno v: Experimental cell research. 201(1)

We have compared the in vitro replicative life span and characteristics of immortalization of skin fibroblast cultures derived from ad libitum-fed and caloric-restricted Fischer 344 rats of 6, 24, and 29 months of age. Cells from all 6-, 24-, and 29-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f4ec3c8ced5ed182886fd74a869531
https://pubmed.ncbi.nlm.nih.gov/1612120

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Karyotypic and phenotypic changes during in vitro aging of human endothelial cells

Autor: Carole I. Bradt, Stephen N. Mueller, Diane R. Umbenhauer, Timothy E. Johnson, Warren W. Nichols, Rosina Hill, Elliot M. Levine

Publikováno v: Journal of cellular physiology. 150(1)

Karyotypic and phenotypic changes were found in human adult endothelial cells (EC) during aging in vitro. A trisomy of chromosome 11 was found in 11 out of 12 EC cultures examined, derived from 9 cell lines from 8 donors. The incidence of this trisom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e6149b47172d88c8c890cf07ab4583
https://pubmed.ncbi.nlm.nih.gov/1309825

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Cytogenetic evaluation of human endothelial cell cultures

Autor: Warren W. Nichols, Buynak Eb, Carole I. Bradt, Rosina Hill, Elliot M. Levine, Margaret M. Aronson, Stephen N. Mueller, Bruce E. Jarrell

Publikováno v: Journal of Cellular Physiology. 132:453-462

Cytogenetic evaluation of serially subcultivated human endothelial cells revealed significant differences between cultures derived from fetal umbilical cords and cultures derived from various vessel sites in adults. A rapid increase in the prevalence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43076a8166748d09ddceafacdf3c2ac8
https://doi.org/10.1002/jcp.1041320307

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Paradoxical changes in SCE frequencies persistently elevated in vivo, on exposure to a mutagen in vitro

Autor: Keith A. Soper, Jill Wartell, Carole I. Bradt, Sandra R. Wolman, Sheila M. Galloway, Warren W. Nichols, Paul D. Stolley, Lynn Andree

Publikováno v: Mutation Research/Genetic Toxicology. 204:445-449

Lymphocyte cultures from 4 individuals with persistently significantly elevated frequencies of sister-chromatid exchange (SCE) were examined with no treatment, and with 2 concentrations of mitomycin C. In each of the 4 cases, the mean level of SCEs i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a9db48c48030eedccbaeb0a516d7c2
https://doi.org/10.1016/0165-1218(88)90040-7

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Cytogenetic studies on human subjects receiving marihuana and Δ-9-Tetrahydrocannabinol

Autor: Warren W. Nichols, Carole I. Bradt, S. Kanter, L. Hollister, W. Heneen, R.C. Miller

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 26:413-417

Summary Cytogenetic analysis of metaphase chromosomes from peripheral blood leukocyte cultures of volunteer male subjects sampled before and after a series of oral applications of marihuana extract, hashish extract, or synthetic Δ-9-THC revealed no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dfc17943b2ed120403085005731aa0
https://doi.org/10.1016/s0027-5107(74)80010-2

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Cytogenetic changes induced in human diploid fibroblasts by tsA58 SV40 at permissive and restrictive temperatures

Autor: Anthony J. Girardi, Carole I. Bradt, Rosina Hill, Christine Cody, Warren W. Nichols

Publikováno v: Mutation research. 150(1-2)

Human diploid fibroblasts have been transformed by ts A58 SV40. At the permissive temperature, apparent chromosome and chromatic rearrangements were observed in a high percentage of cells and the frequency of SCE increased. If the transformed phenoty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae4acc7f58781f43c8d09c3bfa49ada
https://pubmed.ncbi.nlm.nih.gov/2987688

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