Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Carole Desseaux"'
Autor:
Víctor A. Arrieta, Andrew Gould, Kwang-Soo Kim, Karl J. Habashy, Crismita Dmello, Gustavo I. Vázquez-Cervantes, Irina Palacín-Aliana, Graysen McManus, Christina Amidei, Cristal Gomez, Silpol Dhiantravan, Li Chen, Daniel Y. Zhang, Ruth Saganty, Meghan E. Cholak, Surya Pandey, Matthew McCord, Kathleen McCortney, Brandyn Castro, Rachel Ward, Miguel Muzzio, Guillaume Bouchoux, Carole Desseaux, Michael Canney, Alexandre Carpentier, Bin Zhang, Jason M. Miska, Maciej S. Lesniak, Craig M. Horbinski, Rimas V. Lukas, Roger Stupp, Catalina Lee-Chang, Adam M. Sonabend
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed ultrasound (LIPU) and intravenously administered microbub
Externí odkaz:
https://doaj.org/article/79679c002d644430b29884550815aa26
Autor:
Alexandre Carpentier, Roger Stupp, Adam M. Sonabend, Henry Dufour, Olivier Chinot, Bertrand Mathon, François Ducray, Jacques Guyotat, Nathalie Baize, Philippe Menei, John de Groot, Jeffrey S. Weinberg, Benjamin P. Liu, Eric Guemas, Carole Desseaux, Charlotte Schmitt, Guillaume Bouchoux, Michael Canney, Ahmed Idbaih
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and efficacy of blood-brain barrier (BBB) disruption with an implantable ultrasound system in recurrent glioblastoma patients receiving carboplatin are repo
Externí odkaz:
https://doaj.org/article/e712a20f4c934b6c8309df6f0e891005
Autor:
Stéphane Epelbaum, Ninon Burgos, Michael Canney, Dawn Matthews, Marion Houot, Mathieu D. Santin, Carole Desseaux, Guillaume Bouchoux, Sebastian Stroer, Cyril Martin, Marie-Odile Habert, Marcel Levy, Aicha Bah, Karine Martin, Benoît Delatour, Maximilien Riche, Bruno Dubois, Lisa Belin, Alexandre Carpentier
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background Temporary disruption of the blood-brain barrier (BBB) using pulsed ultrasound leads to the clearance of both amyloid and tau from the brain, increased neurogenesis, and mitigation of cognitive decline in pre-clinical models of Alz
Externí odkaz:
https://doaj.org/article/29d7dca3f8e04379b08a640dfa589efc
Autor:
Francesca Stillitano, Jens Hansen, Chi-Wing Kong, Ioannis Karakikes, Christian Funck-Brentano, Lin Geng, Stuart Scott, Stephan Reynier, Ma Wu, Yannick Valogne, Carole Desseaux, Joe-Elie Salem, Dorota Jeziorowska, Noël Zahr, Ronald Li, Ravi Iyengar, Roger J Hajjar, Jean-Sébastien Hulot
Publikováno v:
eLife, Vol 6 (2017)
A large number of drugs can induce prolongation of cardiac repolarization and life-threatening cardiac arrhythmias. The prediction of this side effect is however challenging as it usually develops in some genetically predisposed individuals with norm
Externí odkaz:
https://doaj.org/article/3b878456b2a444ebbdf9d3342f144ebc
Publikováno v:
Journal of Ophthalmology, Vol 2012 (2012)
Ocular gene therapy is rapidly becoming a reality. By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents. Viral infections such as herpetic keratitis caused by herpes simplex virus 1 (HSV-1) can cause se
Externí odkaz:
https://doaj.org/article/0c81389f81d64dd1b23093473a51c1fb
Autor:
Andrew Gould, Victor Andrés Arrieta Gonzales, Crismita Clement Dmello, Ruth Saganty, Rimas V. Lukas, Daniel Y. Zhang, Amy B. Heimberger, Michael Canney, Alexandre Carpentier, Carole Desseaux, Guillaume Bouchoux, Roger Stupp, Adam M. Sonabend
Publikováno v:
Advances in Oncology. 3:77-86
Autor:
Adam M Sonabend, Andrew Gould, Christina Amidei, Rachel Ward, Karyn A Schmidt, Daniel Y Zhang, Cristal Gomez, John F Bebawy, Benjamin P Liu, Guillaume Bouchoux, Carole Desseaux, Irene B Helenowski, Rimas V Lukas, Karan Dixit, Priya Kumthekar, Víctor A Arrieta, Maciej S Lesniak, Alexandre Carpentier, Hui Zhang, Miguel Muzzio, Michael Canney, Roger Stupp
Publikováno v:
The Lancet Oncology. 24:509-522
Autor:
Alexandre Carpentier, Jean-Yves Delattre, Jean-Yves Chapelon, Cyril Lafon, Arthur André, Bertrand Mathon, Florence Laigle-Donadey, Caroline Houillier, Caroline Dehais, Khe Hoang-Xuan, Marc Sanson, Laurent Capelle, Clementine Trosch, Yann De Rycke, Anne Bissery, Delphine Leclercq, Bruno Law-Ye, Nicolas Asquier, Guillaume Bouchoux, Alexandre Vignot, Carole Desseaux, Lisa Belin, Michael Canney, Ahmed Idbaih
Purpose:The blood–brain barrier (BBB) limits the efficacy of drug therapies for glioblastoma (GBM). Preclinical data indicate that low-intensity pulsed ultrasound (LIPU) can transiently disrupt the BBB and increase intracerebral drug concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7bea7e3b24afdd0cd9d56bed9ba6bf
https://doi.org/10.1158/1078-0432.c.6527760
https://doi.org/10.1158/1078-0432.c.6527760
Autor:
Adam M. Sonabend, Roger Stupp, Miguel Muzzio, Michael Canney, Carole Desseaux, Alexandre Carpentier, Craig Horbinski, C. David James, Aneta Baran, Lisa P. Magnusson, J. Robert Kane, Edgar Gonzalez-Buendia, Victor A. Arrieta, Li Chen, Crismita Dmello, Daniel Y. Zhang
Supplementary Methods and Materials Figures S1: Schematic representation of LIPU generator set up. Supp Table 1: Summary of histological evaluation of CNS after one course of US-PTX Supp. Table 2: STR results of PDX cell lines. Figures S2: Cell viabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbc02c3e0420aac8701001ff2523a33
https://doi.org/10.1158/1078-0432.22477926.v1
https://doi.org/10.1158/1078-0432.22477926.v1
Autor:
Alexandre Carpentier, Jean-Yves Delattre, Jean-Yves Chapelon, Cyril Lafon, Arthur André, Bertrand Mathon, Florence Laigle-Donadey, Caroline Houillier, Caroline Dehais, Khe Hoang-Xuan, Marc Sanson, Laurent Capelle, Clementine Trosch, Yann De Rycke, Anne Bissery, Delphine Leclercq, Bruno Law-Ye, Nicolas Asquier, Guillaume Bouchoux, Alexandre Vignot, Carole Desseaux, Lisa Belin, Michael Canney, Ahmed Idbaih
Supplementary Table 1. The acoustic pressure levels are determined by a calibration of the implants in water prior to implantation in patients. The 95% confidence interval given in the table denotes the measurement uncertainty inherent to this proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c994db536a024a49a744ba4c4d114f5
https://doi.org/10.1158/1078-0432.22471062
https://doi.org/10.1158/1078-0432.22471062