Multi-country evaluation of RISK6, a 6-gene blood transcriptomic signature, for tuberculosis diagnosis and treatment monitoring

Autor: Rim Bayaa, Mame Diarra Bousso Ndiaye, Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu, Mohammad Khaja Mafij Uddin, Samanta Biswas, Rumana Nasrin, Paulo Ranaivomanana, Antso Hasina Raherinandrasana, Julio Rakotonirina, Voahangy Rasolofo, Giovanni Delogu, Flavio De Maio, Delia Goletti, Hubert Endtz, Florence Ader, Monzer Hamze, Mohamad Bachar Ismail, Stéphane Pouzol, Niaina Rakotosamimanana, Jonathan Hoffmann, The HINTT working group within the GABRIEL network

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract There is a crucial need for non-sputum-based TB tests. Here, we evaluate the performance of RISK6, a human-blood transcriptomic signature, for TB screening, triage and treatment monitoring. RISK6 performance was also compared to that of two

Externí odkaz: https://doaj.org/article/de33777566a645f5adea0e0e7f01b111

In-Depth Immunophenotyping With Mass Cytometry During TB Treatment Reveals New T-Cell Subsets Associated With Culture Conversion

Autor: Carole Chedid, Thibault Andrieu, Eka Kokhreidze, Nestani Tukvadze, Samanta Biswas, Md. Fahim Ather, Mohammad Khaja Mafij Uddin, Sayera Banu, Flavio De Maio, Giovanni Delogu, Hubert Endtz, Delia Goletti, Marc Vocanson, Oana Dumitrescu, Jonathan Hoffmann, Florence Ader

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Tuberculosis (TB) is a difficult-to-treat infection because of multidrug regimen requirements based on drug susceptibility profiles and treatment observance issues. TB cure is defined by mycobacterial sterilization, technically complex to systematica

Externí odkaz: https://doaj.org/article/c6fef1411b6d41fd90e06d1208c65839

Drug-resistant TB prevalence study in 5 health institutions in Haiti.

Autor: Jonathan Hoffmann, Carole Chedid, Oksana Ocheretina, Chloé Masetti, Patrice Joseph, Marie-Marcelle Mabou, Jean Edouard Mathon, Elie Maxime Francois, Juliane Gebelin, François-Xavier Babin, Laurent Raskine, Jean William Pape

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0248707 (2021)

ObjectivesTuberculosis (TB) is the leading infectious cause of death in the world. Multi-drug resistant TB (MDR-TB) is a major public health problem as treatment is long, costly, and associated to poor outcomes. Here, we report epidemiological data o

Externí odkaz: https://doaj.org/article/4df87c8316cc44c6b06a3db26f61c345

In-depth immunophenotyping with mass cytometry during TB treatment reveals non-canonical T-cell subsets associated with sputum culture conversion

Autor: Sayera Banu, Samanta Biswas, Delia Goletti, Thibault Andrieu, Giovanni Delogu, Nestani Tukvadze, Mohammad Khaja Mafij Uddin, Oana Dumitrescu, Flavio De Maio, Florence Ader, Jonathan Hoffmann, Hubert P. Endtz, Carole Chedid, Md. Fahim Ather, Marc Vocanson, Eka Kokhreidze

Tuberculosis (TB) is a difficult-to-treat infection because of multidrug regimen requirements based on drug susceptibility profiles and treatment observance issues. TB cure is defined by mycobacterial sterilization, technically complex to systematica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e29391f52d07eac869cd4066385e0ec6
https://doi.org/10.1101/2021.10.27.466125

Association of baseline white blood cell counts with tuberculosis treatment outcome: a prospective multicentered cohort study

Autor: Mohamad Bachar Ismail, Crisca Razafimahatratra, Jean-Luc Berland, Mohammad Khaja Mafij Uddin, Monzer Hamze, Niaina Rakotosamimanana, Nestani Tukvadze, Florence Ader, Samanta Biswas, Chyntia Carolina Díaz Acosta, Rossana Arenas, Jonathan Hoffmann, Sayera Banu, Rim Bayaa, Delia Goletti, Giovanni Delogu, Carole Chedid, Perlinot Herindrainy, Eka Kokhreidze, Graciela Russomando, Paulo Ranaivomanana, Hubert P. Endtz

Publikováno v: International Journal of Infectious Diseases, Vol 100, Iss, Pp 199-206 (2020)
International Journal of Infectious Diseases
International Journal of Infectious Diseases, 2020, 100, pp.199-206. ⟨10.1016/j.ijid.2020.09.017⟩
International Journal of Infectious Diseases, Elsevier, 2020, 100, pp.199-206. ⟨10.1016/j.ijid.2020.09.017⟩

International audience; Objectives: Tuberculosis (TB) is the leading infectious cause of death in the world. Cheaper and more accessible TB treatment monitoring methods are needed. Here, we evaluated white blood cell (WBC) absolute counts, lymphocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b8ab05c5bb3df58d6daf6bee37c638
https://pubmed.ncbi.nlm.nih.gov/32920230