Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Carole Bye"'
Autor:
William T. Prince, Christine Falcoz, Scott D. Studenberg, Timothy C. Hardman, Julian Jenkins, Carole Bye, H. Fuder, Kathy B. Kenney
Publikováno v:
The Journal of Clinical Pharmacology. 42:887-898
These two Phase I, open-label, single-dose, randomized, crossoverstudies in 40 healthymale subjects investigated the pharmacokinetic and safety profiles of various formulations of the amprenavir prodrug GW433908 in the presence and absence of food co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b570b6e7e5a04e536162d42f2374c2b4
https://doi.org/10.1177/009127002401102803
https://doi.org/10.1177/009127002401102803
Autor:
Mark E. Sale, Mary S. Richardson, Scott McNeal, Carole Bye, Margaret R. Britto, Katy H. P. Moore
Publikováno v:
Clinical therapeutics. 24(11)
Background: Because the majority of migraineurs are young women in their peak reproductive years, it is important to understand the possible effects on the pharmacokinetics of both medications when sumatriptan is coadministered with an oral contracep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9447e07a373884a3776a55c28551b9ab
https://pubmed.ncbi.nlm.nih.gov/12501881
https://pubmed.ncbi.nlm.nih.gov/12501881
Autor:
Mark E. Sale, Peter Gray, Carole Bye, Philip T. Leese, Scott McNeal, Stephen O'Quinn, Katy H. P. Moore
Publikováno v:
Clinical therapeutics. 24(4)
Background: Macrolide antibiotics such as clarithromycin are potent inhibitors of the cytochrome P450 (CYP)3A4 isozyme and have the potential to attenuate the metabolism and increase blood concentrations of drugs metabolized by this pathway. In vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0df8bbe89f2a2a73e1fc54e65fd8639
https://pubmed.ncbi.nlm.nih.gov/12017403
https://pubmed.ncbi.nlm.nih.gov/12017403
Publikováno v:
European Journal of Clinical Pharmacology. 10:231-236
The intestinal absorption and urinary elimination rate of total cardioactive material was compared following digoxin and beta-methyldigoxin (BMD) administration to twelve healthy volunteers. Significantly more injected digoxin was recovered in urine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::007a8a120cb1b7631e65cfbe91b9820a
https://doi.org/10.1007/bf00558334
https://doi.org/10.1007/bf00558334
Publikováno v:
European Journal of Clinical Pharmacology. 14:357-360
(1) The mean cumulative urinary digoxin excretion over 8 days was compared in 8 healthy volunteers after single doses of digoxin administered as 3 Lanoxin tablets of 0.25 mg, 3 digoxin tablets of 0.2 mg, 12 Lanoxicaps without sorbitol of 0.05 mg, 6 L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92bc657446c0a16a9effb8786e1c49ab
https://doi.org/10.1007/bf00611906
https://doi.org/10.1007/bf00611906
Publikováno v:
European Journal of Clinical Pharmacology. 8:47-53
Plasma concentrations of L(+)pseudoephedrine administered in clinically used dosages were determined by gas liquid chromatography using a nitrogen sensitive detector. They were measured after administration of an immediate release formulation (Sudafe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf974673459345fdcb28c7de82a1cd5a
https://doi.org/10.1007/bf00616414
https://doi.org/10.1007/bf00616414
Publikováno v:
Clinical Pharmacology & Therapeutics. 23:315-319
The influence of food on absorption of digoxin was studied in 6 healthy volunteers who received 1.0 mg digoxin as 4 tablets of Lanoxin either after an overnight fast, immediately after a standard breakfast, or 90 min after a standard breakfast. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634ec18a31163462cf1b2a83e0c9c59c
https://doi.org/10.1002/cpt1978233315
https://doi.org/10.1002/cpt1978233315
Publikováno v:
The Lancet. 301:1473-1475
Five experimental batches of 0·25 mg. tablets demonstrated large differences in the rate of dissolution of their digoxin content in a described apparatus. In twenty healthy volunteers, following treatment periods of one tablet every 12 hours for 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148bbe5c6b2d4fc53ac9a8a996b1d6fc
https://doi.org/10.1016/s0140-6736(73)91811-4
https://doi.org/10.1016/s0140-6736(73)91811-4
Publikováno v:
Clinical science and molecular medicine. Supplement. 3
1. Seven healthy sodium-replete male volunteer subjects remained supine during and for at least 1 h before the study. Heart rate and blood pressure were recorded continuously, and peripheral venous blood samples were taken every 15 min for determinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbc97535a59ab21f83a95403b22dc9c
https://pubmed.ncbi.nlm.nih.gov/192510
https://pubmed.ncbi.nlm.nih.gov/192510
Publikováno v:
Clinical pharmacology and therapeutics. 19(6)
Digoxin absorption was studied in healthy volunteers by determination of peak plasma concentrations, areas under plasma concentration curves, and urinary excretion after single-dose administration. By comparison with an aqueous solution, increased ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f32c6d29b05c0854dcef10b2602deeb
https://pubmed.ncbi.nlm.nih.gov/1269214
https://pubmed.ncbi.nlm.nih.gov/1269214