Lighting a Fire in the Tumor Microenvironment Using Oncolytic Immunotherapy

Autor: Carole Achard, Abera Surendran, Marie-Eve Wedge, Guy Ungerechts, John Bell, Carolina S. Ilkow

Publikováno v: EBioMedicine, Vol 31, Iss , Pp 17-24 (2018)

Oncolytic virus (OV) therapy is potentially a game-changing cancer treatment that has garnered significant interest due to its versatility and multi-modal approaches towards tumor eradication. In the field of cancer immunotherapy, the immunological p

Externí odkaz: https://doaj.org/article/e33778759e55432b9d99062d2bf747b2

Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus

Autor: Christophe Blanquart, Stephane Minvielle, Laurent Cellerin, Nicolas Boisgerault, Jaafar Bennouna, Didier Jean, Pierre-Joseph Royer, Marion Grard, Tiphaine Delaunay, Jean-François Fonteneau, Camille Chatelain, Carole Achard, Marc Grégoire, Clément Meiller, Antoine Magnan, Frédéric Tangy, Lisa Quetel, Delphine Fradin, Soizic Dutoit, Tacien Petithomme

Publikováno v: Journal of Thoracic Oncology
Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2020, S1556-0864(20)30019-8, Epub ahead of print. ⟨10.1016/j.jtho.2019.12.128⟩
Journal of Thoracic Oncology, 2020, S1556-0864(20)30019-8, Epub ahead of print. ⟨10.1016/j.jtho.2019.12.128⟩

Introduction Oncolytic immunotherapy is based on the use of nonpathogenic replicative oncolytic viruses that infect and kill tumor cells exclusively. Recently, we found that the spontaneous oncolytic activity of the Schwarz strain of measles virus (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74ff75083ee017e786aeca0f9e711e7
https://www.hal.inserm.fr/inserm-02447160/document

Human natural killer cells promote cross-presentation of tumor cell-derived antigens by dendritic cells

Autor: Nadège Goutagny, Isabelle Durand, Colette Dezutter-Dambuyant, Thierry Walzer, Raffaella Ghittoni, Jacqueline Marvel, Carole Achard, Florence Deauvieau, Jean-François Fonteneau, Estelle Verronese, Anne-Claire Doffin, Ivan Perrot, Jenny Valladeau-Guilemond, Vincent Ollion, Henri Vié, Christophe Caux

Publikováno v: International Journal of Cancer. 136:1085-1094

Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce477374215604b2bdd1c4b2b6df66d4
https://doi.org/10.1002/ijc.29087

Modulation of the Type I Interferon Response Defines the Sensitivity of Human Melanoma Cells to Oncolytic Measles Virus

Autor: Brigitte Dréno, Amel Benammar Elgaaied, Jean-François Fonteneau, Marc Grégoire, Clarisse Panterne, Carole Achard, Daniel Pouliquen, Nicolas Boisgerault, Frédéric Tangy, Ferdaous Allagui, Chantal Combredet, Nathalie Labarrière

Publikováno v: Current Gene Therapy
Current Gene Therapy, 2016, ⟨10.2174/156652321766617010211⟩
Current Gene Therapy, Bentham Science Publishers, 2016, ⟨10.2174/156652321766617010211⟩

International audience; Background: Oncolytic viruses such as live-attenuated, vaccine strains of measles virus (MV) have recently emerged as promising cancer treatments, having shown significant antitumor activity against a large variety of human tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6df4e6a8d759b39e7980352e384c5b
https://www.hal.inserm.fr/inserm-01480242

Induction of Immunogenic Tumor Cell Death by Attenuated Oncolytic Measles Virus

Autor: Nicolas Boisgerault, Marc Grégoire, Jean-François Fonteneau, Frédéric Tangy, Tiphaine Delaunay, Carole Achard

Publikováno v: Journal of Clinical and Cellular Immunology
Journal of Clinical and Cellular Immunology, OMICS Publishing Group, 2015, 6 (1), http://omicsonline.org/open-access/induction-of-immunogenic-tumor-cell-death-by-attenuated-oncolytic-measles-virus-2155-9899-1000291.php?aid=38192. ⟨10.4172/2155-9899.1000291⟩
Journal of Clinical and Cellular Immunology, 2015, 6 (1), http://omicsonline.org/open-access/induction-of-immunogenic-tumor-cell-death-by-attenuated-oncolytic-measles-virus-2155-9899-1000291.php?aid=38192. ⟨10.4172/2155-9899.1000291⟩

International audience; Antitumor virotherapy is a developing approach to treat cancer with oncolytic viruses, namely replicative viruses that exclusively or preferentially infect and kill tumor cells. Attenuated strains of Measles Virus (MV) are now

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b481d66d313f97dfbe3c99d65b653813
https://www.hal.inserm.fr/inserm-01148993/file/induction-of-immunogenic-tumor-cell-death-by-attenuated-oncolytic-measles-virus-2155-9899-1000291.pdf