Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Carole A. Perruzzi"'
Autor:
Laura E. Benjamin, Sandaruwan Geeganage, Dina Lev, Marcelo L. Hochman, Ladan Enayati, Paul Rodriguez-Waitkus, Rajesh Ramanna-Valmiki, Isabel Acevedo, Carole A. Perruzzi, Sokha Nhek, Zeus Antonello, Damien Gerald, Sriram Ayyaswamy, Qi Xue, Wa Du, Thuy L. Phung
Vascular tumors are endothelial cell neoplasms whose mechanisms of tumorigenesis are poorly understood. Moreover, current therapies, particularly those for malignant lesions, have little beneficial effect on clinical outcomes. In this study, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6df64b26bba8a45b1e3f9bc3b082faf
https://doi.org/10.1158/0008-5472.c.6505943
https://doi.org/10.1158/0008-5472.c.6505943
Autor:
Laura E. Benjamin, Sandaruwan Geeganage, Dina Lev, Marcelo L. Hochman, Ladan Enayati, Paul Rodriguez-Waitkus, Rajesh Ramanna-Valmiki, Isabel Acevedo, Carole A. Perruzzi, Sokha Nhek, Zeus Antonello, Damien Gerald, Sriram Ayyaswamy, Qi Xue, Wa Du, Thuy L. Phung
Supplementary Figure S1. Phosphorylated-Akt staining in human vascular tumors. Immunohistochemical stains for phospho-Akt (S473) in normal human skin and human vascular tumors. Representative areas of "low" and "high" levels of staining within a tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97aa2608be9148984985447caadfb1de
https://doi.org/10.1158/0008-5472.22401908
https://doi.org/10.1158/0008-5472.22401908
Autor:
Laura E. Benjamin, Carole A. Perruzzi, Beverly L. Falcon, Whitney E. Goldstein, William C. Aird, Jeffrey C. Hanson, Shahin Rafii, Rebekah K. O'Donnell
Publikováno v:
Cancer Research. 76:517-524
Antiangiogenesis–based cancer therapies, specifically those targeting the VEGF-A/VEGFR2 pathway, have been approved for subsets of solid tumors. However, these therapies result in an increase in hematologic adverse events. We surmised that both the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee49e0600da935e498273b5b88ec04c
https://doi.org/10.1158/0008-5472.can-14-3023
https://doi.org/10.1158/0008-5472.can-14-3023
Autor:
Aimee Lin, Christoph Reinhard, Ann M. McNulty, Jack A. Dempsey, Adem Abel, Marguerita O’Mahony, Ricardo Martinez, Damien Gerald, Greg Donoho, Carole A. Perruzzi, Wenjuan Wu, Jennifer R. Stephens
Publikováno v:
Cancer Research. 79:3513-3513
Reported genomic alterations in the DNA repair pathway in studies of castrate-resistant prostate cancer (CRPC) patients have prompted interests in targeted therapies related to the DNA damage response (DDR). CHK1 kinase plays a critical role in media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc3dd6ddf1495cde59215786303009a2
https://doi.org/10.1158/1538-7445.am2019-3513
https://doi.org/10.1158/1538-7445.am2019-3513
Autor:
Dina Lev, Ladan Enayati, Bhuvaneswari Krishnan, Damien Gerald, Paul Rodriguez-Waitkus, Wa Du, Carole A. Perruzzi, Thuy L. Phung, Joseph L. Edmonds, Marcelo Hochman
Publikováno v:
Laboratory Investigation. 93:1115-1127
Vascular tumors are endothelial cell neoplasms whose cellular and molecular mechanisms, leading to tumor formation, are poorly understood, and current therapies have limited efficacy with significant side effects. We have investigated mechanistic (ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba8765b683ca419f3d5fe3ce82ad3ef
https://doi.org/10.1038/labinvest.2013.98
https://doi.org/10.1038/labinvest.2013.98
Autor:
Y. Rebecca Chin, Laura E. Benjamin, George C. Prendergast, Damien Gerald, James B. DuHadaway, Shiva Kazerounian, Lawrence F. Brown, Lee E. Mangiante, Olivier Kocher, Thuy L. Phung, Minzhou Huang, Carole A. Perruzzi, Ningning Zheng, Sharon Shechter, Alex Toker, Jacob Pourat, Rebekah K. O'Donnell, Durga Udayakumar, Stephanie L. McNamara, Arturo Bravo-Nuevo
Publikováno v:
Cancer Research. 73:50-61
Tumors are composed of cancer cells but also a larger number of diverse stromal cells in the tumor microenvironment. Stromal cells provide essential supports to tumor pathophysiology but the distinct characteristics of their signaling networks are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcce306e2a1245ea08059866154253c2
https://doi.org/10.1158/0008-5472.can-11-3055
https://doi.org/10.1158/0008-5472.can-11-3055
Autor:
Thuy L. Phung, Rita A. Monahan-Earley, Kenneth Walsh, Michelle I. Lin, Godfred Eyiah-Mensah, Michal Neeman, Harold F. Dvorak, Carole A. Perruzzi, Jingfang Sun, Donnette Dabydeen, Keren Ziv, Laura E. Benjamin, William C. Sessa, Ann M. Dvorak, Marcela Riveros, Janice A. Nagy, Ichiro Shiojima, David M. Briscoe
Publikováno v:
Cancer Cell. 10:159-170
SummaryEndothelial cells in growing tumors express activated Akt, which when modeled by transgenic endothelial expression of myrAkt1 was sufficient to recapitulate the abnormal structural and functional features of tumor blood vessels in nontumor tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed52baf1b03c24b982247345fbc60940
https://doi.org/10.1016/j.ccr.2006.07.003
https://doi.org/10.1016/j.ccr.2006.07.003
Autor:
Jeffery E. Green, Alfonso Calvo, Lois E.H. Smith, Donald R. Senger, Carole A. Perruzzi, Gregory S. Robinson, Iqbal Unnisa Ali, Shu-Ching Shih, Kartiki V. Desai
Publikováno v:
The American Journal of Pathology. 161:35-41
The goal of this study was to develop a sensitive, simple, and widely applicable assay to measure copy numbers of specific mRNAs using real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and identify a profile of gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::724c247ac034ff65f3da7113aa53dab0
https://doi.org/10.1016/s0002-9440(10)64154-5
https://doi.org/10.1016/s0002-9440(10)64154-5
Autor:
Marcelo Hochman, Sokha Nhek, Paul Rodriguez-Waitkus, Laura E. Benjamin, Wa Du, Sriram Ayyaswamy, Dina Lev, Zeus A. Antonello, Sandaruwan Geeganage, Qi Xue, Ladan Enayati, Damien Gerald, Rajesh Ramanna-Valmiki, Thuy L. Phung, Carole A. Perruzzi, Isabel Acevedo
Publikováno v:
Cancer research. 75(1)
Vascular tumors are endothelial cell neoplasms whose mechanisms of tumorigenesis are poorly understood. Moreover, current therapies, particularly those for malignant lesions, have little beneficial effect on clinical outcomes. In this study, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0568c3835ffa6d35df3ff28ba42d40d
https://pubmed.ncbi.nlm.nih.gov/25388284
https://pubmed.ncbi.nlm.nih.gov/25388284
Autor:
William C. Aird, Laura E. Benjamin, Whitney E. Goldstein, Carole A. Perruzzi, Rebekah K. O'Donnell
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55095 (2013)
PLoS ONE
PLoS ONE
Under steady state conditions, erythropoiesis occurs in the bone marrow. However, in mice, stress or tissue hypoxia results in increased erythropoiesis in the spleen. There is increasing evidence that the hematopoietic microenvironment, including end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00c33059f58ff5283cfc36704441321
http://europepmc.org/articles/PMC3557261?pdf=render
http://europepmc.org/articles/PMC3557261?pdf=render