Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Autor: Ida Alexandersson, Nahida Arifen, Firoozeh Salehzadeh, Anders Thorell, Carolina E. Hagberg, Jeremie Boucher, Kirsty L. Spalding, Qian Li, Ping Chen, Niels Krämer, Matthew J. Harms, Carole Knibbe, Shuai Lang, Helena Silva Cascales, Eleni Terezaki, Mervi T. Hyvönen, Myriam Aouadi, Maria Kutschke

Publikováno v: Nature Medicine
Nature Medicine, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩

International audience; Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c988f76cf18afe80c100c7135c054e
https://doi.org/10.1038/s41591-021-01501-8

Uptake of fatty acids by the enterocyte: New insights gained from mathematical modeling

Autor: Marie-Caroline Michalski, Julie Etienne, Armelle Penhoat, Carole Knibbe

Publikováno v: 2021 AOCS Annual Meeting & Expo
2021 AOCS Annual Meeting & Expo, May 2021, online, United States
GERLI 2021-16th Lipidomics Meeting
GERLI 2021-16th Lipidomics Meeting, Sep 2021, Bordeaux, France
GERLI 16th LIPIDOMICS MEETING (2021)
GERLI 16th LIPIDOMICS MEETING (2021), Sep 2021, Bordeaux, France
AOCS Annual Meeting & Expo 2021
AOCS Annual Meeting & Expo 2021, May 2021, Online, United States

Poster followed by an oral communication; International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c78ae597614e1f10bde654501962122
https://hal.inrae.fr/hal-03252034

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Autor: Qian, Li, Carolina E, Hagberg, Helena, Silva Cascales, Shuai, Lang, Mervi T, Hyvönen, Firoozeh, Salehzadeh, Ping, Chen, Ida, Alexandersson, Eleni, Terezaki, Matthew J, Harms, Maria, Kutschke, Nahida, Arifen, Niels, Krämer, Myriam, Aouadi, Carole, Knibbe, Jeremie, Boucher, Anders, Thorell, Kirsty L, Spalding

Publikováno v: Nature medicine. 27(11)

Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differentiation and mature adipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::719fa533dd18963cc50171abb7ae7d49
https://pubmed.ncbi.nlm.nih.gov/34675377

Differential Metabolic Impact of Natural Food-Grade Emulsifiers Rich in Alpha-Linolenic Acid

Autor: Carole Vaysse, Marie-Caroline Michalski, Laurence Fonseca, Carole Knibbe, Emmanuelle Loizon, Charline Buisson, Chloé Robert, Emmanuelle Meugnier, Fabienne Laugerette, Leslie Couëdelo

Publikováno v: Curr Dev Nutr

OBJECTIVES: Dietary synthetic emulsifiers have recently been shown to promote metabolic syndrome and considerably alter gut microbiota. Conversely, natural emulsifiers such as milk polar lipids (PL) are associated with beneficial metabolic effects. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978403465283ae3ac5bad5cf9b2b75c9
https://europepmc.org/articles/PMC7258870/

Phenotypic Noise and the Cost of Complexity

Autor: Charles Rocabert, Carole Knibbe, Guillaume Beslon, Samuel Bernard

Publikováno v: EvoLyon 2019
EvoLyon 2019, Nov 2019, Lyon, France
Evolution-International Journal of Organic Evolution
Evolution-International Journal of Organic Evolution, 2020, ⟨10.1111/evo.14083⟩
Evolution-International Journal of Organic Evolution, Wiley, 2020, ⟨10.1111/evo.14083⟩

Experimental studies demonstrate the existence of phenotypic diversity despite constant genotype and environment. Theoretical models based on a single phenotypic character predict that during an adaptation event, phenotypic noise should be positively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decdbcbb433f5f47a273a6a54b5eea9d
https://hal.archives-ouvertes.fr/hal-02402443/file/poster2_v3.pdf