Výsledky vyhledávání - "Carola Pongratz"

Akademický článek

Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA library.

Autor: Carola Pongratz, Benjamin Yazdanpanah, Hamid Kashkar, Maik J Lehmann, Hans-Georg Kräusslich, Martin Krönke

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13172 (2010)

RNA interference (RNAi) has been considered as an efficient therapeutic approach against the human immunodeficiency virus type 1 (HIV-1). However, to establish a durable inhibition of HIV-1, multiple effective short hairpin RNAs (shRNAs) need to be s

Externí odkaz: https://doaj.org/article/dc8f010013af4309bf754b005fde4b6f

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A tissue‐specific screen of ceramide expression in aged mice identifies ceramide synthase‐1 and ceramide synthase‐5 as potential regulators of fiber size and strength in skeletal muscle

Autor: Olaf Utermöhlen, Martina Deckert, Daniela Wenzel, Franziska Peters, Carola Pongratz, Wolfram Doehner, Martin Krönke, Bettina Tosetti, Susanne Brodesser, Matthias Blüher, Bernd K. Fleischmann, Stefan D. Anker, Anna Brunn

Publikováno v: Aging Cell

Loss of skeletal muscle mass is one of the most widespread and deleterious processes in aging humans. However, the mechanistic metabolic principles remain poorly understood. In the framework of a multi‐organ investigation of age‐associated change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9154b788f1230c497b912453becfa63
http://europepmc.org/articles/PMC6974707

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TNF-receptor-1 adaptor protein FAN mediates TNF-induced B16 melanoma motility and invasion

Autor: Nikola Baschuk, D Haubert, Cristian Dan Neacsu, Olaf Utermöhlen, Hamid Kashkar, Carola Pongratz, Martin Krönke, A Boecke, A C Carstens

Publikováno v: British Journal of Cancer

It has become apparent that tumours are complex ecologies of different cell types and that the full manifestation of the malignant potential of transformed epithelial cells requires an appropriate support structure from the stroma. Haematopoietic cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4df877f9ccf9a2d11bf89d045407321
https://doi.org/10.1038/bjc.2013.242

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Elevated XIAP expression alone does not confer chemoresistance

Autor: Carola Pongratz, Jens M. Seeger, Benjamin Yazdanpanah, Dirk Haubert, Hamid Kashkar, Martin Krönke, Oliver Coutelle, Kerstin Brinkmann

Publikováno v: British Journal of Cancer

Background: In various tumour types, elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been observed and XIAP targeting in diverse tumour entities enhanced the susceptibility to chemotherapeutic agents. Therefore, XIAP has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec5592c632adb5667b75f86c74bf77a
https://doi.org/10.1038/sj.bjc.6605704

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Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

Autor: Michael Schramm, Vladimir Tchikov, Hamid Kashkar, Katja Wiegmann, Martin Krönke, Olaf Utermöhlen, Oleg Krut, Stefan Schütze, Benjamin Yazdanpanah, Carola Pongratz, Jens C. Brüning, André Kleinridders, Thomas F. Wunderlich

Publikováno v: Nature. 460:1159-1163

Riboflavin kinase has been identified as a novel interacting partner for the death domain of receptor-1 for tumour necrosis factor (TNF-R1). It is required to recruit to and functionally couple p22phox to TNF-R1. As p22phox is the catalytic subunit o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2048121b50d99add006dbbb2fad626
https://doi.org/10.1038/nature08206

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Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6

Autor: Maria Andree, Rudolf J. Wiesner, Saskia Diana Günther, Stephan Schüll, Kerstin Brinkmann, F Diaz, Jens M. Seeger, Carola Pongratz, Hamid Kashkar, Susanne Brodesser, Martin Krönke, Katja Wiegmann, Axel Witt, Bettina Tosetti

Publikováno v: Cell Death & Disease

Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602355d7797b63eb1bdb8367b76d09f6
https://doi.org/10.1038/cddis.2015.62

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NF-kappaB-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugs

Autor: Martin Krönke, Anke Deggerich, Carola Pongratz, Dirk Haubert, Katja Wiegmann, Hamid Kashkar, Jens-Michael Seeger, Benjamin Yazdanpanah

Publikováno v: Blood. 109(9)

The proteasome inhibitor bortezomib has been shown to possess promising antitumor activity and significant efficacy against a variety of malignancies. Different studies demonstrated that bortezomib breaks the chemoresistance in different tumor cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada36aba82127bfc439b12cd60f5b530
https://pubmed.ncbi.nlm.nih.gov/17185461

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Targeting of HIV-1 Tat traffic and function by transduction-competent single chain antibodies

Autor: Francisco Rivero, Oleg Krut, Katja Wiegmann, Martin Krönke, Carola Pongratz, Dietmar M. Theisen

Publikováno v: Vaccine. 24(16)

Human immunodeficiency virus type 1-encoded Tat protein is a transactivating factor essentially required for viral replication. Tat binds specifically to the transactivation response RNA stem loop, which is formed at the 5' end of all viral transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd17e9d1919f683bff7734efe998e020
https://pubmed.ncbi.nlm.nih.gov/16497417

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