Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Carola A Reitsma-Wijker"'
Autor:
Rob J. van Andel, Gitta K. Kuipers, M. Vincent M. Lafleur, Carola A. Reitsma-Wijker, Ben J. Slotman, Hester A. Poldervaart
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 568(2), 171-7. Elsevier
Kuipers, G K, Slotman, B J, Reitsma-Wijker, CA, Andel, R J, Poldervaart, H A & Lafleur, M V M 2004, ' Influence of anoxia on the induction of mutations by phenylalanine radicals during gamma-irradiation of plasmid DNA in aqueous solution. ', Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 568, no. 2, pp. 171-7 . https://doi.org/10.1016/j.mrfmmm.2004.08.005
Kuipers, G K, Slotman, B J, Reitsma-Wijker, CA, Andel, R J, Poldervaart, H A & Lafleur, M V M 2004, ' Influence of anoxia on the induction of mutations by phenylalanine radicals during gamma-irradiation of plasmid DNA in aqueous solution. ', Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 568, no. 2, pp. 171-7 . https://doi.org/10.1016/j.mrfmmm.2004.08.005
When DNA is irradiated in aqueous solution, most of the damage is inflicted by water-derived radicals. This is called the indirect effect of ionizing radiation. However in whole cells not only the primary formed water radicals play a role, because so
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 454:71-76
Irradiation of DNA in aqueous solution or in cells with gamma-rays results in different mutational spectra, indicating that in both situations different patterns of DNA damages are induced. One of the causes for these different types of damages might
Autor:
Gitta K. Kuipers, Hester A Poldervaart, M. Vincent M. Lafleur, Ben J. Slotman, Carola A Reitsma-Wijker
Publikováno v:
Mutation Research/DNA Repair. 461:189-195
One of the most predominating oxidative DNA damages, both spontaneously formed and after gamma-radiation is 7, 8-dihydro-8-oxoguanine (8oxoG). This 8oxoG is a mutagenic lesion because it can mispair with adenine instead of the correct cytosine leadin
Autor:
Gitta K. Kuipers, Hester A Poldervaart, Ben J. Slotman, Carola A Reitsma-Wijker, Ingrid M.J van Vilsteren, M. Vincent M. Lafleur
Publikováno v:
Mutation Research/DNA Repair. 460:117-125
Base excision repair (BER) is a very important repair mechanism to remove oxidative DNA damage. A major oxidative DNA damage after exposure to ionizing radiation is 7,8-dihydro-8-oxoguanine (8oxoG). 8oxoG is a strong mutagenic lesion, which may cause