Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Carol W. Gray"'
Autor:
H. Wadsworth, David Allsop, R. Markwell, Robin V. Ward, Colin L. Masters, Eric Karran, Konrad Beyreuther, Roberto Cappai, Gary Christie, L. Smith, S. K. Gribble, Tobias Hartmann, A. Tamaoka, R. L. Gardner, D. R. Howlett, F. Mansfield, F. Godfrey, Michael R. McLaughlin, Rodney A. King, A. J. Rivett, D. G. Cooper, Carol W. Gray, Stefan F. Lichtenthaler, John R. Underwood
Publikováno v:
Journal of Neurochemistry. 73:195-204
Peptide aldehyde inhibitors of the chymotrypsin-like activity of the proteasome (CLIP) such as N-acetyl-Leu-Leu-Nle-H (or ALLN) have been shown previously to inhibit the secretion of beta-amyloid peptide (A beta) from cells. To evaluate more fully th
Autor:
Sandra Turconi, Caretha L. Creasy, Robin V. Ward, Eric Karran, Owen Jenkins, Carol W. Gray, Paul S. Carter, Gary Pettman, John Savopoulos
Publikováno v:
Protein Expression and Purification. 19:227-234
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product. Although the physiological function of members of this new family is unclear, the current understandi
Autor:
Carol W. Gray, Gary Christie, David Allsop, John B. Davis, Eric Karran, Robin V. Ward, F. Mansfield
Publikováno v:
Biochemical Society Transactions. 26:491-496
The discovery of the PS proteins, the complexities of their biochemistry and their potential involvement in signalling pathways and in apoptosis have galvanized research into AD. To date, the aspect of the functionality of the PSs most relevant to th
Autor:
Ambrish J. Patel, Carol W. Gray
Publikováno v:
Molecular Brain Research. 19:251-256
In cultured astrocytes, all three major transcripts of beta-amyloid precursor protein (APP) were expressed with the ratio for APP695, APP751 and APP770 isoform mRNAs being 1:4:2. In comparison with controls, treatment of astrocytes with transforming
Autor:
Mike Dragunow, Carol W. Gray, John F. Pearson, Matthew J. During, Andree G. Pearson, Jeffrey M. Greenwood
Publikováno v:
Brain research. Molecular brain research. 120(1)
The AP-1 transcription factor c-Jun is induced in axotomized neurons of the peripheral and central nervous systems, and in both cases upregulation of c-Jun expression has been correlated with axonal regeneration. More recently there has been interest
Autor:
Eric Karran, Carol W. Gray
A detailed understanding of the biochemical events leading to the proteolytic excision of the β-amyloid peptide (A β) from the amyloid precursor protein (APP) has eluded many researchers. This is largely because the measurement of the various APP p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c28a9c353e923579bf4e5c68991e1c6b
https://doi.org/10.1385/1-59259-195-7:217
https://doi.org/10.1385/1-59259-195-7:217
Autor:
Carol W. Gray, John Savopoulos, Stephen Gschmeissner, Ingram Iaccarino, Caretha L. Creasy, Tencho Tenev, Julian Downward, L. Miguel Martins, Nicholas R. Lemoine, Colin Dingwall, Nicholas F. Totty
Publikováno v:
The Journal of biological chemistry. 277(1)
The inhibitor-of-apoptosis proteins (IAPs) play a critical role in the regulation of apoptosis by binding and inhibiting caspases. Reaper family proteins and Smac/DIABLO use a conserved amino-terminal sequence to bind to IAPs in flies and mammals, re
Autor:
Mike Hutton, Vivienne F. Murphy, G.W. Roberts, Karen Duff, Matilde Caivano, John B. Davis, John Hardy, Amanda J. L. Barton, Laura G. Bresciani, Eric Karran, Carol W. Gray, Robin V. Ward
Publikováno v:
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 5(4)
Presenilin-1 (PS-1) has been identified as the protein encoded by the chromosome 14 locus that, when mutated, leads to familial Alzheimer's disease (FAD). Using PS-1 transfected SHSY5Y neuroblastoma cells, we have demonstrated by immunodetection, usi
Autor:
Carol W. Gray, Ambrish J. Patel
Publikováno v:
Brain research. 691(1-2)
In Alzheimer's disease, abnormal extracellular accumulations of beta-amyloid (a major component of the senile plaques) and of the excitatory amino acid glutamate are both thought to be associated with degeneration of nerve cells. In the present study
Autor:
Ambrish J. Patel, Carol W. Gray
Publikováno v:
Neuroreport. 4(6)
All three major transcripts of beta-amyloid precursor protein (APP) were expressed in astrocytes. The ratio for APP695, APP751 and APP770 isoform mRNAs being 1:4:2. Treatment with bFGF and EGF produced upregulation of APP mRNAs in cultured astrocytes