Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro

Autor: Lorna J. Daniels, Marco Annandale, Parisa Koutsifeli, Xun Li, Carol T. Bussey, Isabelle van Hout, Richard W. Bunton, Philip J. Davis, Sean Coffey, Rajesh Katare, Regis R. Lamberts, Lea M. D. Delbridge, Kimberley M. Mellor

Publikováno v: Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-7 (2021)

Abstract Diabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct role for fructose involvement in diabetic heart pathology has not been investigat

Externí odkaz: https://doaj.org/article/71cc5f2d30f7420783f9df21ea649854

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Autor: Sunil Jit R.J. Logantha, James O. Tellez, Mark R. Boyett, Eman S.H. Abd Allah, Cali Anderson, P. Mesirca, Natalie Chandler, Matthew K. Lancaster, Matteo E. Mangoni, Joseph Yanni, George Hart, Jonathan P. Ariyaratnam, Matthew Smith, Henggui Zhang, Robert S. Stephenson, Luke Stuart, Gwilym M. Morris, Claire Wilson, Xue Cai, Rudi Billeter, Alicia D'Souza, Annalisa Bucchi, Sandra C. Jones, Oliver J. Monfredi, Carol T. Bussey, Shu Nakao

Publikováno v: Progress in Biophysics and Molecular Biology
Progress in Biophysics and Molecular Biology, Elsevier, 2021, 166, pp.61-85. ⟨10.1016/j.pbiomolbio.2021.06.008⟩
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Boyett, M, Yanni Gerges, J, Tellez, J O, Bucchi, A, Mesirca, P, Cai, X, Logantha, S J R J, Wilson, C, Anderson, C, Ariyaratnam, J, Stuart, L, Nakao, S, Allah, E A, Jones, S A, Lancaster, M, Stephenson, R S, Chandler, N, Smith, M, Bussey, C, Monfredi, O, Morris, G, Billeter, R, Mangoni, M E, Zhang, H, Hart, G & D'Souza, A 2021, ' Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease ', Progress in biophysics and molecular biology, vol. 166, pp. 61-85 . https://doi.org/10.1016/j.pbiomolbio.2021.06.008

The funny current, I f, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that I f plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca59f382de5f1aaf3a82a41bd3b8182
https://doi.org/10.1016/j.pbiomolbio.2021.06.008

Photoactivation of tDodSNO induces localized vasodilation in rats: Metabolically stable S-nitrosothiols can act as targeted nitric oxide donors in vivo

Autor: Gregory I. Giles, Jeffrey R. Erickson, Carol T. Bussey

Publikováno v: Nitric oxide : biology and chemistry. 129

Nitric oxide (NO) is a key vasodilatory signalling molecule and NO releasing molecules (NO donors) are being examined as potential treatments for many pathologies. The photoresponsive NO donor tert-dodecane S-nitrosothiol (tDodSNO) has been designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61db0cdfb77bb1b04aa0166c50a7ab7
https://pubmed.ncbi.nlm.nih.gov/36209988

β 2 ‐Adrenoceptors indirectly support impaired β 1 ‐adrenoceptor responsiveness in the isolated type 2 diabetic rat heart

Autor: Carol T. Bussey, Gillian Hughes, Andrew Bahn, Patricia A. Cragg, Regis R. Lamberts, Ingrid C. Fomison-Nurse, Rosalind F. Cook

Publikováno v: Experimental Physiology. 104:808-818

NEW FINDINGS What is the central question of this study? Are there specific contributions of β1 - and β2 -adrenoceptor subtypes to the impaired β-adrenoceptor responsiveness of the type 2 diabetic heart? What is the main finding and its importance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ef565c05c3ae6f8e47859b9ce62b985
https://doi.org/10.1113/ep087437

Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro

Autor: Rajesh Katare, L. Daniels, Parisa Koutsifeli, Carol T. Bussey, Isabelle van Hout, Sean Coffey, Kimberley M. Mellor, Lea M.D. Delbridge, Philip Davis, Richard W. Bunton, Regis R. Lamberts, Marco Annandale, X. Li

Publikováno v: Nutrition & Diabetes
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-7 (2021)

Diabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct role for fructose involvement in diabetic heart pathology has not been investigated. The g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ee8d2fb60a03b9afd7dd8ec208aea6
https://doi.org/10.1038/s41387-021-00150-7