DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity

Autor: Konstantinos Papadopoulos, Paul Lancett, E.Andrew Boyd, Ian Collins, Stuart Hatcher, Brian Dymock, Paul N. Mortenson, Stephanie Barker, Chandana Chowdhury, Peter Ingram, Stephen P. East, Clara Bantry White, James Workman, Christopher James Brennan, David Brown, Jim Bennett, Rowena Fletcher, Oliver Barker, Carol Smee, Emmanuelle Convers-Reignier, Mihaly Gardiner, Lloyd George Czaplewski, David J. Haydon, Helena Thomaides-Brears, Heather Tye

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:894-899

The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd89849d8c7c9d819089fad0a79b88d8
https://doi.org/10.1016/j.bmcl.2008.11.102

Managing clinically significant findings in research: The UK10K example

Autor: David R. FitzPatrick, Stephanie O.M. Dyke, Alastair Kent, Francesco Muntoni, Martin Bobrow, Jasjote Grewal, Karen Kennedy, Nic Timpson, Lucy Raymond, Jane Kaye, Richard Durbin, Dawn Muddyman, Robert K. Semple, Matthew E. Hurles, Patrick Bolton, Heather Griffin, Tim D. Spector, Carol Smee

Publikováno v: European Journal of Human Genetics 22 (2014), Nr. 9
Kaye, J, Hurles, M, Griffin, H, Grewal, J, Bobrow, M, Timpson, N, Smee, C, Bolton, P, Durbin, R, Dyke, S, Fitzpatrick, D, Kennedy, K, Kent, A, Muddyman, D, Muntoni, F, Raymond, L F, Semple, R, Spector, T 2014, ' Managing clinically significant findings in research : the UK10K example ', European Journal of Human Genetics, vol. 22, no. 9, pp. 1100-1104 . https://doi.org/10.1038/ejhg.2013.290
European Journal of Human Genetics
Kaye, J, Hurles, M, Griffin, H, Grewal, J, Bobrow, M, Timpson, N, Smee, C, Bolton, P, Durbin, R, Dyke, S, Fitzpatrick, D, Kennedy, K, Kent, A, Muddyman, D, Muntoni, F, Raymond, L F, Semple, R & Spector, T 2014, ' Managing clinically significant findings in research : the UK10K example ', European Journal of Human Genetics . https://doi.org/10.1038/ejhg.2013.290

Recent advances in sequencing technology allow data on the human genome to be generated more quickly and in greater detail than ever before. Such detail includes findings that may be of significance to the health of the research participant involved.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61bf9936714ce77bcf85296e41664f4

Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression

Autor: Binesh, Shrestha, Carol, Smee, Opher, Gileadi

Publikováno v: Methods in molecular biology (Clifton, N.J.). 439

The increasing demand for production and characterization of diverse groups of recombinant proteins necessitates the analysis of several constructs and fusion tags in a variety of expression systems. The challenge is to screen multiple clones quickly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36cbbac9580192a2515bfd2be0a16778
https://pubmed.ncbi.nlm.nih.gov/18370110

High throughput production of recombinant human proteins for crystallography

Autor: N.A. Burgess-Brown, Eidarus Salah, Carol Smee, Peter Loppnau, Nadia H. Pantic, Steve M. Colebrook, Pavel Savitsky, Georgina Berridge, Catrine Johansson, Opher Gileadi

Publikováno v: Scopus-Elsevier
Methods in Molecular Biology ISBN: 9781588298096

This chapter presents in detail the process used in high throughput bacterial production of recombinant human proteins for crystal structure determination. The core principles are: (1) Generating at least 10 truncated constructs from each target gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab9adb32e9a8114e23fdbe86e099287
http://ora.ox.ac.uk/objects/uuid:e4792ffa-ce2c-47dd-9cbe-b9d823f4ea78

Corrigendum to 'DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity' [Bioorg. Med. Chem. Lett. 19 (2009) 894]

Autor: Heather Tye, Ian Collins, Konstantinos Papadopoulos, David Brown, Rowena Fletcher, Peter Ingram, Carol Smee, Stuart Hatcher, Paul N. Mortenson, Chandana Chowdhury, Lloyd George Czaplewski, James Workman, Mihaly Gardiner, Oliver Barker, Stephen P. East, Christopher James Brennan, Paul Lancett, Brian W. Dymock, Emmanuelle Convers-Reignier, Stephanie Barker, David J. Haydon, Clara Bantry White, E.Andrew Boyd, Helena Thomaides-Brears, Jim Bennett

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:2606

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9784f75e7d2ddb7d5b99f96922901c5
https://doi.org/10.1016/j.bmcl.2008.11.120