Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Carol Sheppard"'
Autor:
Simona Pilotto, Thomas Fouqueau, Natalya Lukoyanova, Carol Sheppard, Soizick Lucas-Staat, Luis Miguel Díaz-Santín, Dorota Matelska, David Prangishvili, Alan C. M. Cheung, Finn Werner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design. Here, the authors present the cryo-EM structures of apo Sulfolobus acidocaldarius RNAP an
Externí odkaz:
https://doaj.org/article/3d39de805d944392bdd55093bfcb0759
Autor:
Carol Sheppard, Fabian Blombach, Adam Belsom, Sarah Schulz, Tina Daviter, Katherine Smollett, Emilie Mahieu, Susanne Erdmann, Philip Tinnefeld, Roger Garrett, Dina Grohmann, Juri Rappsilber, Finn Werner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
How archaeal viruses perturb host transcription machinery is poorly understood. Here, the authors provide evidence that the archaeo-viral transcription factor ORF145/RIP targets host RNA polymerase, repressing its activity.
Externí odkaz:
https://doaj.org/article/fe48d2500b7346f9935066ca430c0d80
Autor:
Fabian Blombach, Enrico Salvadori, Thomas Fouqueau, Jun Yan, Julia Reimann, Carol Sheppard, Katherine L Smollett, Sonja V Albers, Christopher WM Kay, Konstantinos Thalassinos, Finn Werner
Publikováno v:
eLife, Vol 4 (2015)
Transcription initiation of archaeal RNA polymerase (RNAP) and eukaryotic RNAPII is assisted by conserved basal transcription factors. The eukaryotic transcription factor TFIIE consists of α and β subunits. Here we have identified and characterised
Externí odkaz:
https://doaj.org/article/3533bfbc654245ed8b3a41c4a5bb2ca4
Autor:
Thomas Fouqueau, David Prangishvili, Finn Werner, Dorota Matelska, Natalya Lukoyanova, Luis Miguel Díaz-Santín, Alan C. M. Cheung, Simona Pilotto, Soizick Lucas-Staat, Carol Sheppard
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5523. ⟨10.1038/s41467-021-25666-5⟩
Nature Communications, 2021, 12 (1), pp.5523. ⟨10.1038/s41467-021-25666-5⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5523. ⟨10.1038/s41467-021-25666-5⟩
Nature Communications, 2021, 12 (1), pp.5523. ⟨10.1038/s41467-021-25666-5⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
RNA polymerase inhibition plays an important role in the regulation of transcription in response to environmental changes and in the virus-host relationship. Here we present the high-resolution structures of two such RNAP-inhibitor complexes that pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae4eaf705b32f8514a4f45ed6258983
https://doi.org/10.1038/s41467-021-25666-5
https://doi.org/10.1038/s41467-021-25666-5
Autor:
Ecco Staller, Wendy S. Barclay, Vanessa Sancho-Shimizu, Laury Baillon, Rebecca Frise, Carol Sheppard, Thomas P. Peacock
Publikováno v:
The Journal of General Virology
Viruses require host factors to support their replication, and genetic variation in such factors can affect susceptibility to infectious disease. Influenza virus replication in human cells relies on ANP32 proteins, which are involved in assembly of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abf0973a4bddc0e829bd332e96c785f
https://doi.org/10.1099/jgv.0.001664
https://doi.org/10.1099/jgv.0.001664
Publikováno v:
Annual Review of Virology. 6:215-233
Influenza viruses are a leading cause of seasonal and pandemic respiratory illness. Influenza is a negative-sense single-stranded RNA virus that encodes its own RNA-dependent RNA polymerase (RdRp) for nucleic acid synthesis. The RdRp catalyzes mRNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5096ce0f4e568de74ffdcec1497d56e9
https://doi.org/10.1146/annurev-virology-092917-043339
https://doi.org/10.1146/annurev-virology-092917-043339
Autor:
Max Whiteley, Thomas P. Peacock, Jie Zhou, Wendy S. Barclay, Niluka Goonawardane, Carol Sheppard, Jonathan Brown, Thushan I de Silva
The spike (S) glycoprotein of the SARS-CoV-2 virus that emerged in 2019 contained a suboptimal furin cleavage site at the S1/S2 junction with the sequence 681PRRAR/S686. This cleavage site is required for efficient airway replication, transmission, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e771015bf68204e0508a157d1b19ca7
https://doi.org/10.1101/2021.05.28.446163
https://doi.org/10.1101/2021.05.28.446163
Autor:
Thomas P. Peacock, Olivia C. Swann, Ecco Staller, Carol Sheppard, Wendy S. Barclay, Daniel H. Goldhill, Rebecca Frise, Jason S. Long
ANP32 proteins, which act as influenza polymerase co-factors, vary between birds and mammals. The well-known mammalian adaptation, PB2-E627K, enables influenza polymerase to use mammalian ANP32 proteins. However, some mammalian-adapted influenza viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be210ca2ff39a0c39a6c8d04c745aa4
https://doi.org/10.1101/2020.09.03.282384
https://doi.org/10.1101/2020.09.03.282384
Autor:
Laury Baillon, Rebecca Frise, Vanessa Sancho-Shimizu, Ecco Staller, Thomas P. Peacock, Carol Sheppard, Wendy S. Barclay
Viruses require host factors to support their replication, and genetic variation in such factors can affect susceptibility to infectious disease. Influenza virus replication in human cells relies on ANP32 proteins, which are involved in assembly of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07efd902c736c74b09c4161ee9e242e
https://doi.org/10.1101/2020.04.06.027482
https://doi.org/10.1101/2020.04.06.027482
Autor:
Finn Werner, Carol Sheppard
Publikováno v:
Extremophiles
Virus-encoded transcription factors have been pivotal in exploring the molecular mechanisms and regulation of gene expression in bacteria and eukaryotes since the birth of molecular biology, while our understanding of viral transcription in archaea i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37ecff284254387c38b2496c42f5f92
https://doi.org/10.1007/s00792-017-0951-1
https://doi.org/10.1007/s00792-017-0951-1