Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Carol S. Lai"'
Autor:
Kathryn R Coser, Ivana Nikolic, Xiuli Huang, Anthony J Faugno, Samuel D Paskin-Flerlage, Stephen P. Berasi, Kari E. Roberts, Geoffrey A. Bocobo, Paul D. Upton, Lai Ming Yung, Rajeev Malhotra, Teresa Dinter, Raymond T. Chung, Kathleen E. Tumelty, Megan E. McNeil, Nicholas W. Morrell, Arthur Lee, Carol S. Lai, Marie-José Goumans, Wei Zheng, Luca Troncone, Christine Huard, Peiran Yang, C. Gregory Elliott, Richard W Channick, Paul B. Yu, Roham T. Zamanian
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 199(7), 891-902. AMER THORACIC SOC
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
RATIONALE: BMP9 (bone morphogenetic protein 9) is a circulating endothelial quiescence factor with protective effects in pulmonary arterial hypertension (PAH). Loss-of-function mutations in BMP9, its receptors, and downstream effectors have been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64dbe9c17a8e976df4f924f8d01c0dc
http://hdl.handle.net/1887/122297
http://hdl.handle.net/1887/122297
Autor:
Panagis Filippakopoulos, Jana Bagarova, Kelli A. Armstrong, Carol S. Lai, Donna Y. Deng, Nicholas W. Morrell, Jan Börgermann, Yuji Mishina, I. Alfano, Petra Knaus, Alex N. Bullock, Paul B. Yu, Ashley J. Vonner, Hideyuki Beppu
Publikováno v:
Molecular and Cellular Biology. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398468f65f7fea6c0cf543f45d5a4d5e
https://doi.org/10.1128/mcb.00284-17
https://doi.org/10.1128/mcb.00284-17
Autor:
Donna Y. Deng, Roham T. Zamanian, Samuel D Paskin-Flerlage, Robert Spencer, Jonathan W. Schmidt, Richard N. Channick, Patrick Zimmerman, Nicholas W. Morrell, C. Gregory Elliott, William Parker, Mark Southwood, Paul B. Yu, Carol S. Lai, Rajeev Malhotra
Publikováno v:
Pulmonary Circulation
The diagnosis of pulmonary arterial hypertension (PAH) is frequently delayed. We hypothesized that circulating angiogenic modulatory protein levels might correspond with vascular remodeling activity and serve as sensitive biomarkers of PAH. Levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4875dbc02753a802d006167e8156e340
https://doi.org/10.4103/2045-8932.110445
https://doi.org/10.4103/2045-8932.110445
Autor:
Rushdia Z. Yusuf, Kristen M. Rauwerdink, Ashley J. Vonner, Julia C. Winn, Cindy N. Roy, Jasbir Seehra, Paul B. Yu, Borja Saez, Carol S. Lai, Donna Y. Deng, Chetana Sachidanandan, Gregory D. Cuny, Andrea U. Steinbicker, Colleen Cook, Brian A. Szekely, Randall T. Peterson, David T. Scadden, Kenneth D. Bloch
Publikováno v:
Blood. 117:4915-4923
Anemia of inflammation develops in settings of chronic inflammatory, infectious, or neoplastic disease. In this highly prevalent form of anemia, inflammatory cytokines, including IL-6, stimulate hepatic expression of hepcidin, which negatively regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6005d6e32757f9a2be953d157dea2c
https://doi.org/10.1182/blood-2010-10-313064
https://doi.org/10.1182/blood-2010-10-313064
Autor:
Tomokazu Fukuda, Mary L. Bouxsein, Yuji Mishina, Kenneth D. Bloch, Nobuhiro Kamiya, Gregory D. Cuny, Carol S. Lai, Charles C. Hong, Deborah W. Hong, Patrick M. McManus, Paul B. Yu, Chetana Sachidanandan, Donna Y. Deng, Takenobu Katagiri, Randall T. Peterson
Publikováno v:
Nature Medicine. 14:1363-1369
Fibrodysplasia ossificans progressiva (FOP) is a congenital disorder of progressive and widespread postnatal ossification of soft tissues1–4 and is without known effective treatments. Affected individuals harbor conserved mutations in the ACVR1 gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35a36b2f058f6828a8162d6c0a2fd73
https://doi.org/10.1038/nm.1888
https://doi.org/10.1038/nm.1888
Autor:
Kelli A. Armstrong, Panagis Filippakopoulos, Jana Bagarova, Petra Knaus, Ashley J. Vonner, Nicholas W. Morrell, Yuji Mishina, I. Alfano, Paul B. Yu, Alex N. Bullock, Donna Y. Deng, Hideyuki Beppu, Carol S. Lai, Jan Börgermann
Publikováno v:
Molecular and cellular biology. 33(12)
Constitutively activating mutations in receptor kinases recruit downstream effector pathways independently of upstream signaling, with consequences ranging from developmental syndromes to cancer. Classic fibrodysplasia ossificans progressiva (FOP) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26f73b0cec263e890159c4f889d3f96
http://ora.ox.ac.uk/objects/uuid:934c5136-f4a2-401f-85b0-a7ecaec7d87a
http://ora.ox.ac.uk/objects/uuid:934c5136-f4a2-401f-85b0-a7ecaec7d87a
Autor:
Xuechao Xing, Kenneth D. Bloch, Gregory D. Cuny, Joydev K. Laha, Ji-Feng Liu, Donna Y. Deng, Carol S. Lai, Chetana Sachidanandan, Paul B. Yu, Randall T. Peterson
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
A structure-activity relationship study of dorsomorphin, a previously identified inhibitor of SMAD 1/5/8 phosphorylation by bone morphogenetic protein (BMP) type 1 receptors ALK2, 3, and 6, revealed that increased inhibitory activity could be accompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa9dc048f6171bd0f6f528560498b54
https://pubmed.ncbi.nlm.nih.gov/18621530
https://pubmed.ncbi.nlm.nih.gov/18621530
Autor:
Carol S. Lai, Hideyuki Beppu, Paul B. Yu, Stefan A Hoyng, Charles C. Hong, Kenneth D. Bloch, Donna Y. Deng, Noriko Kawai
Publikováno v:
The Journal of biological chemistry. 283(7)
Bone morphogenetic protein (BMP) signals regulate the growth and differentiation of diverse lineages. The association of mutations in the BMP type II receptor (BMPRII) with idiopathic pulmonary arterial hypertension suggests an important role of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba1455db1a83c562f29e3b8e6815e23
https://pubmed.ncbi.nlm.nih.gov/18042551
https://pubmed.ncbi.nlm.nih.gov/18042551
Autor:
Paul B. Yu, Chetana Sachidanandan, Gregory D. Cuny, Tomokazu Fukuda, Mary L. Bouxsein, Deborah W. Hong, Yuji Mishina, Patrick M. McManus, Kenneth D. Bloch, Carol S. Lai, Nobuhiro Kamiya, Donna Y. Deng, Takenobu Katagiri, Randall T. Peterson, Charles C. Hong
Publikováno v:
Nature Medicine. 15:117-117
Nat. Med. 14, 1363–1369 (2008); published online 30 November 2008; corrected after print 4 December 2008 In the version of this article initially published, the title included a misspelling—'heterotropic' should have been 'heterotopic'. Additiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93a9d072d5d965ad0b0ca4fbb2762fc
https://doi.org/10.1038/nm0109-117a
https://doi.org/10.1038/nm0109-117a