Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Carol S. Himes"'
Autor:
Wenning Qin, Rongqing Shuang, Gregory J. Fici, Richard L. Myers, Adele M. Pauley, Chai An Mao, Ismail Kola, Jinhe Li, Carol S Himes, Gregory P. Donoho, Jeffrey S. Nye, Kalpana M. Merchant
Publikováno v:
Journal of Biological Chemistry. 278:33445-33449
Nicastrin is a component of the gamma-secretase complex that has been shown to adhere to presenilin-1 (PS1), Notch, and APP. Here we demonstrate that Nicastrin-deficient mice showed a phenotype that is indistinguishable from PS1/PS2 double knock-out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797d2fdb7c28d27a2b593322f6cb603c
https://doi.org/10.1074/jbc.m301288200
https://doi.org/10.1074/jbc.m301288200
Autor:
Annette L. Parks, Jeffrey S. Nye, Daniel Tim Curtis, Carol S. Himes, Ross Francis, Bing Hai, Jianhuan Zhang, David A. Ruddy, Michael C. Ellis, Richard L. Myers, Ronald Hiebsch, Cara L. Ruble, Javier Apfeld, Jinhe Li, Mark E. Gurney, Mary Sym, Mark E. Maxwell, Garth Joseph Mcgrath, Wei Xu, Monique Nicoll
Publikováno v:
Developmental Cell. 3(1):85-97
Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11bca1732c82c37329da15ad8aa1ce
Autor:
Carol S. Himes, Andrew H. Tang
Publikováno v:
European Journal of Pharmacology. 284:13-18
Apomorphine induced yawning in both Sprague-Dawley and F344 rats in the same dose range, but F344 rats emitted only about 1 4 as many yawns as did Sprague-Dawley rats. At higher doses, rats of both strains exhibited stereotypic behavior with a compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9296f212ffcb3ce35cef5845588440e5
https://doi.org/10.1016/0014-2999(95)00317-e
https://doi.org/10.1016/0014-2999(95)00317-e
Autor:
Lisa A Adams, Carol S Himes, Ben M Amore, Kalpana M. Merchant, Shinji Yamazaki, Giovanni Pallante, Thomas A. Lanz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 305(3)
Acute, s.c. administration of a gamma-secretase inhibitor, N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT), to young PDAPP mice dose dependently decreases cortical amyloid-beta (A beta). The present studies replicated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bafcf64667ce6db3399f0a95cc38ce
https://pubmed.ncbi.nlm.nih.gov/12626636
https://pubmed.ncbi.nlm.nih.gov/12626636
Publikováno v:
Neurology. 50(1)
Riluzole was tested in a dose-ranging study for preservation of motor function in a transgenic mouse model of familial ALS. The model is based on expression of mutant human Cu,Zn superoxide dismutase in mouse brain and spinal cord. In contrast with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb248876c305081a3e9de4699a6ee14
https://pubmed.ncbi.nlm.nih.gov/9443458
https://pubmed.ncbi.nlm.nih.gov/9443458
Publikováno v:
European journal of pharmacology. 236(1)
The benzodiazepine receptor agonists, flurazepam, zolpidem, ZK 93423, and the benzodiazepine inverse agonist, FG 7142, all produced hypothermia when injected i.p. in mice. These compounds are structurally different and do not have the same affinity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34426eb39df5c7aa549d94809bc94204
https://pubmed.ncbi.nlm.nih.gov/8391449
https://pubmed.ncbi.nlm.nih.gov/8391449
Autor:
Denise D McKinley, Adele M. Pauley, Carol S Himes, Nancy C. Stratman, Alfredo G. Tomasselli, Brenda R Ellerbrook, Edwige Dunn, Donald B. Carter, Jeffrey S. Nye, Timothy J. Fleck, Riqiang Yan, Xiangdong Zhou
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 3, Iss 1, p 6 (2008)
Molecular Neurodegeneration, Vol 3, Iss 1, p 6 (2008)
Presenilin (PS1 or PS2) is an essential component of the active γ-secretase complex that liberates the Aβ peptides from amyloid precursor protein (APP). PS1 is regarded as an atypical aspartyl protease harboring two essential aspartic acids in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fe3bbbf9ccd91d6ef4d268448809bf