Removal of p16INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice

Autor: Steve D. Guzman, Jennifer Judge, Shahjahan M. Shigdar, Thomas A. Paul, Carol S. Davis, Peter C. Macpherson, James F. Markworth, Holly Van Remmen, Arlan Richardson, Anne McArdle, Susan V. Brooks

Publikováno v: Frontiers in Aging, Vol 2 (2022)

Aging results in the progressive accumulation of senescent cells in tissues that display loss of proliferative capacity and acquire a senescence-associated secretory phenotype (SASP). The tumor suppressor, p16INK4A, which slows the progression of the

Externí odkaz: https://doaj.org/article/624eb338e7c1447186d014f1dd94f006

Older mice show decreased regeneration of neuromuscular junctions following lengthening contraction-induced injury

Autor: Thomas A. Paul, Peter C. Macpherson, Tara L. Janetzke, Carol S. Davis, Malcolm J. Jackson, Anne McArdle, Susan V. Brooks

Publikováno v: GeroScience.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::564dfb16d1b4923dbe4e8d5d7e289c43
https://doi.org/10.1007/s11357-023-00774-w

Sestrins are evolutionarily conserved mediators of exercise benefits

Autor: Jun Hee Lee, Allison H. Kowalsky, Seung-Hyun Ro, Alyson Sujkowski, Susan V. Brooks, Carol S. Davis, Bondong Gu, Robert Wessells, Sim Namkoong, Michael Karin, Myungjin Kim, Ian A. Semple, Tyler Cobb, Boyoung Kim, Chun-Seok Cho

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature communications, vol 11, iss 1

Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c0e136eb996872baac923fc89158a1
http://link.springer.com/article/10.1038/s41467-019-13442-5

Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

Autor: Arlan Richardson, Susan V. Brooks, Peter C. D. Macpherson, Meixiang Huang, Yu Su, Holly Van Remmen, Dennis R. Claflin, Carol S. Davis

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10735, p 10735 (2021)

Skeletal muscle suffers atrophy and weakness with aging. Denervation, oxidative stress, and mitochondrial dysfunction are all proposed as contributors to age-associated muscle loss, but connections between these factors have not been established. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164cbe2760b8d6e037841929175c7c2c

Metabolipidomic profiling reveals an age-related deficiency of skeletal muscle pro-resolving mediators that contributes to maladaptive tissue remodeling

Autor: Jesus A. Castor-Macias, Carol S. Davis, Carlos A. Aguilar, Peter C. D. Macpherson, Susan V. Brooks, Eunice Lim, Jacqueline Larouche, James F. Markworth, Krishna Rao Maddipati, Lemuel A. Brown

Publikováno v: Aging Cell

Specialized pro‐resolving mediators actively limit inflammation and support tissue regeneration, but their role in age‐related muscle dysfunction has not been explored. We profiled the mediator lipidome of aging muscle via liquid chromatography�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eade513250d035e28a9bb8f8acfb346
https://pubmed.ncbi.nlm.nih.gov/34075679