Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Carol Ricca"'
Publikováno v:
ChemInform. 31
Design, synthesis and structure-activity relationship of a series of 3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines as farnesyltransferase inhibitors are presented. A working pharmacophore of inhibiting farnesyltransferase by this series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6bd49d5117f136d15039288fca8d296
https://doi.org/10.1002/chin.200021132
https://doi.org/10.1002/chin.200021132
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:273-275
Design, synthesis and structure-activity relationship of a series of 3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines as farnesyltransferase inhibitors are presented. A working pharmacophore of inhibiting farnesyltransferase by this series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0b849fba90461481d062396762e4b3
https://doi.org/10.1016/s0960-894x(99)00686-1
https://doi.org/10.1016/s0960-894x(99)00686-1
Autor:
Peng Guo, William A. Slusarchyk, Becky Penhallow, Rajeev S. Bhide, William C. Rose, Soong Hoon Kim, Manorama Patel, Young Cho, Gregory D. Vite, Sam T. Chao, Roberta Batorsky, John T. Hunt, Carol Ricca, Saeho Chong, Charles Z. Ding, Mark S. Bednarz, Veeraswamy Manne, Robert J. Schmidt, Toomas Mitt, Arthur V. Miller, Katerina Leftheris, Francis Y. Lee, Johnni Gullo-Brown
Publikováno v:
Journal of medicinal chemistry. 43(20)
Continuing structure-activity studies were performed on the 2,3,4, 5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors. These studies demonstrated that a 3(R)-phenylmethyl group, a hydrophilic 7-cyano group, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a702ec2024ac26e2b1ba1eba758d3bb
https://pubmed.ncbi.nlm.nih.gov/11020273
https://pubmed.ncbi.nlm.nih.gov/11020273
Autor:
Donald R. Gustavson, Prabhavathi B. Fernandes, Joseph O'sullivan, Carol Ricca, Junius M. Clark, Kin Sing Lam, Jessica A. Gorman, Dolores M. Pirnik, S. W. Mamber, Li-Ping Chang
Publikováno v:
The Journal of antibiotics. 49(6)
Ascosteroside, a novel antifungal compound, was isolated from the culture broth of Ascotricha amphitricha. This compound is an alpha-linked glycoside of a lanostane type triterpenoid. It is active against yeasts such as Candida albicans and Saccharom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da8245e92471373252d6d34e219f594
https://pubmed.ncbi.nlm.nih.gov/8698637
https://pubmed.ncbi.nlm.nih.gov/8698637
Autor:
Joan M. Carboni, Ving G. Lee, John Mabus, Carol Ricca, Veeraswamy Manne, Bernd R. Seizinger, Ning Yan, Katerina Leftheris, John T. Hunt
Publikováno v:
Journal of medicinal chemistry. 39(2)
All previously reported CAAX-based farnesyltransferase inhibitors contain a thiol functionality. We report that attachment of the 4-imidazolyl group, via 1-, 2-, or 3-carbon alkyl or alkanoyl spacers, to Val-Tic-Met or tLeu-Tic-Gln provides potent FT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3214f22452e39eacbea4a0bbee673225
https://pubmed.ncbi.nlm.nih.gov/8558502
https://pubmed.ncbi.nlm.nih.gov/8558502
Autor:
Dinesh V. Patel, Joan M. Carboni, Robert J. Schmidt, William C. Rose, Carol Ricca, Bernd R. Seizinger, Harold N. Weller, Toni B. Kline, Manorama Patel, Katerina Leftheris, Young Cho, Gregory D. Vite, Mary L. Andahazy, Chester A. Meyers, Ning Yan, Robert Zahler, Francis Y. Lee, Mariano Barbacid, John T. Hunt, Veeraswamy Manne, Johnni Gullo-Brown, Rajeev S. Bhide
Publikováno v:
Journal of medicinal chemistry. 39(1)
Analogs of CVFM (a known nonsubstrate farnesyltransferase (FT) inhibitor derived from a CA1A2X sequence where C is cysteine, A is an aliphatic residue, and X is any residue) were prepared where phenylalanine was replaced by (Z)-dehydrophenylalanine,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1d40ec6c4a8339c8eaf0d13d2b6638
https://pubmed.ncbi.nlm.nih.gov/8568812
https://pubmed.ncbi.nlm.nih.gov/8568812
Autor:
Dinesh V. Patel, Eric M. Gordon, Robert J. Schmidt, Harold N. Weller, Marian G. Young, Robert Zahler, Mariano Barbacid, Joan M. Carboni, Johnni L. Gullo-Brown, Lisa Hunihan, Carol Ricca, Simon Robinson, Bernd R. Seizinger, Anne V. Tuomari, Veeraswamy Manne
Publikováno v:
Journal of medicinal chemistry. 38(3)
The rational design, synthesis, and biological activity of phosphonyl- and phosphinyl-linked bisubstrate analog inhibitors of the enzyme Ras farnesyl protein transferase (FPT) are described. The design strategy for these bisubstrate inhibitors involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91835b967fd962ba3adaa99a90eb8912
https://pubmed.ncbi.nlm.nih.gov/7853336
https://pubmed.ncbi.nlm.nih.gov/7853336
Autor:
Pacifico A. Principe, J. Scott Wells, William H. Trejo, Philip C. Ward, Carol Ricca, Pushpa D. Singh, Richard B. Sykes
Publikováno v:
The Journal of antibiotics. 35(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517e3b295351b05604094c9c3c0aa71e
https://pubmed.ncbi.nlm.nih.gov/7174523
https://pubmed.ncbi.nlm.nih.gov/7174523
Autor:
Dagmara Zlotkowska, Massimo Maddaloni, Carol Riccardi, Nancy Walters, Kathryn Holderness, Gayle Callis, Agnieszka Rynda-Apple, David W Pascual
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36182 (2012)
Ovalbumin (OVA) genetically fused to protein sigma 1 (pσ1) results in tolerance to both OVA and pσ1. Pσ1 binds in a multi-step fashion, involving both protein- and carbohydrate-based receptors. To assess the relative pσ1 components responsible fo
Externí odkaz:
https://doaj.org/article/2ff1cfef666e4f53b40334314f8af72b