Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Carol R. Tometsko"'
Autor:
Monique Parenteau, George Bolcsfoldi, Jenness B. Majeska, P. V. Bellier, Ingrid Pontén, Carol R. Tometsko, Shuou Zhao, James P. McNamee, Bas-jan van der Leede, Carol W. Johnson, Kerstin Sandelin, Philippe Vanparys, Stephen D. Dertinger, Amira Pearson, David H. Blakey, Anne H. Illi-Love, Lynnette R. Ferguson, James P. Tarca, Geoffrey M. Hynes, Anthony M. Lynch, Janet Bayley, Philip R. Harbach, Nikki E. Hall, Dorothea K. Torous, Marilyn S. Diehl, Anthony L. Filipunas, Karin Cederbrant
Publikováno v:
Environmental and Molecular Mutagenesis. 45:44-55
An interlaboratory study was performed to validate an anti-CD71/flow cytometry-based technique for enumerating micronucleated reticulocytes (MN-RETs) in mouse peripheral blood. These experiments were designed to address International Workshop on Geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5029831e1b2563511f4615978f36e65a
https://doi.org/10.1002/em.20081
https://doi.org/10.1002/em.20081
Autor:
Michelle E. Bishop, Carol R. Tometsko, George Bolcsfoldi, Siân E. Cairns, Yuhchyau Chen, Ingrid Pontén, Kerstin Sandelin, Cynthia Ménard, Stephen D. Dertinger, Kevin Camphausen, James T. MacGregor, Karin Cederbrant, Thierry Muanza, Svetlana L. Avlasevich, Dorothea K. Torous, Richard K. Miller
Publikováno v:
Environmental and Molecular Mutagenesis. 44:427-435
Experiments described herein were designed to evaluate the performance characteristics of a flow cytometry-based system that scores the incidence of peripheral blood micronucleated reticulocytes (MN-RETs). These procedures represent the continued ref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::254615354b581a5b80bbbac28fc4d807
https://doi.org/10.1002/em.20075
https://doi.org/10.1002/em.20075
Autor:
Carol R. Tometsko, T. Smudzin, Kelly J. Brewer, Kristine A. Olvany, Yuhchyau Chen, Richard K. Miller, Francis G. Murante, Nikki E. Hall, Dorothea K. Torous, Stephen D. Dertinger
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 542:77-87
The frequency of micronuclei (also known as Howell-Jolly bodies) in peripheral blood erythrocytes of humans is extremely low due to the efficiency with which the spleen sequesters and destroys these aberrant cells. In the past, this has precluded ery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486a2107b4b28d686eabf63ca6b7b319
https://doi.org/10.1016/j.mrgentox.2003.08.004
https://doi.org/10.1016/j.mrgentox.2003.08.004
Autor:
Richard K. Miller, Nikki E. Hall, Dorothea K. Torous, Sarah E. Gleason, Stephen D. Dertinger, Carol R. Tometsko, Francis G. Murante
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 515:3-14
The extreme rarity of micronucleated reticulocytes (RETs) in the peripheral blood of non-splenectomized humans has precluded facile enumeration of these cells, as well as evaluation of this endpoint as an index of cytogenetic damage. In this report,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7487289ae68badee3f26bd64807e85c
https://doi.org/10.1016/s1383-5718(02)00009-8
https://doi.org/10.1016/s1383-5718(02)00009-8
Publikováno v:
Mutagenesis. 17:15-23
A single laser flow cytometric procedure to quantify micronucleus frequency in rat and mouse peripheral blood was evaluated. Reticulocytes express the transferrin receptor (also known as the CD71-defined antigen). When combined with a DNA stain, anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005a5ea0e750d9805bbf013ce90b3965
https://doi.org/10.1093/mutage/17.1.15
https://doi.org/10.1093/mutage/17.1.15
Autor:
Dorothea K. Torous, Thomas A. Gasiewicz, Nikki E. Hall, Stephen D. Dertinger, Carol R. Tometsko
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 464:195-200
A procedure for optimizing the configuration of flow cytometers for enumerating micronucleated erythrocytes is described. The method is based on the use of a biological model for micronucleated erythrocytes, the malaria parasite Plasmodium berghei. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7f188c6e78f8d4fdc3c4fd36212927
https://doi.org/10.1016/s1383-5718(99)00183-7
https://doi.org/10.1016/s1383-5718(99)00183-7
Publikováno v:
Environmental and Molecular Mutagenesis. 31:340-344
A flow cytometric (FCM) procedure for quantitating micronucleated reticulocytes in mouse peripheral blood samples was evaluated for its ability to discriminate between aneugen- and clastogen-induced micronuclei (MN). In this experiment, BALB/c mice w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ee69abf2f626837df309bcb32381b30
https://doi.org/10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co
Publikováno v:
Current Protocols in Toxicology
The formation of micronuclei in blood cells has been an established indicator of genotoxicity for decades. Standard microscopy methods are time-consuming and lack the objectivity that fully automated methods can provide. The ability of flow cytometri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71529dfcdeb00fcd89d401b52277cf0
https://pubmed.ncbi.nlm.nih.gov/20941695
https://pubmed.ncbi.nlm.nih.gov/20941695
Publikováno v:
Current Protocols in Cytometry
The in vivo rodent micronucleus test is widely utilized to screen chemicals for genotoxic activity. Double-strand chromosome breaks or dysfunction of the mitotic spindle apparatus can lead to micronuclei formation in dividing cells. Erythrocytes have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0864c3797b1a607bc71d1c20155fa4
https://pubmed.ncbi.nlm.nih.gov/18770782
https://pubmed.ncbi.nlm.nih.gov/18770782
Autor:
Makoto Hayashi, Stephen D. Dertinger, Dorothea K. Torous, Norihide Asano, Carol R. Tometsko, Takeshi Morita
Publikováno v:
Mutagenesis. 21(1)
Micronucleus induction was studied for the DNA target clastogens mitomycin C (MMC) and 1-beta-D-arabinofuranosylcytosine (Ara-C), and also the non-DNA target aneugen colchicine (COL) in order to evaluate the dose-response relationship at very low dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4d5f72445ae70a41d6ac9ede7e4c5f
https://pubmed.ncbi.nlm.nih.gov/16364928
https://pubmed.ncbi.nlm.nih.gov/16364928