Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Carol MacKintosh"'
Autor:
Chao Quan, Qian Du, Min Li, Ruizhen Wang, Qian Ouyang, Shu Su, Sangsang Zhu, Qiaoli Chen, Yang Sheng, Liang Chen, Hong Wang, David G. Campbell, Carol MacKintosh, Zhongzhou Yang, Kunfu Ouyang, Hong Yu Wang, Shuai Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the developmen
Externí odkaz:
https://doaj.org/article/5daf127d28454b4bae80efceddb9c9af
Autor:
Carol MacKintosh, David E.K. Ferrier
Publikováno v:
F1000Research, Vol 6 (2018)
Ancient whole-genome duplications (WGDs)—paleopolyploidy events—are key to solving Darwin’s ‘abominable mystery’ of how flowering plants evolved and radiated into a rich variety of species. The vertebrates also emerged from their invertebra
Externí odkaz:
https://doaj.org/article/57538a3de8be4c4f8aba6e97bd8af5f0
Autor:
Carol MacKintosh, David E.K. Ferrier
Publikováno v:
F1000Research, Vol 6 (2017)
Ancient whole-genome duplications (WGDs)—paleopolyploidy events—are key to solving Darwin’s ‘abominable mystery’ of how flowering plants evolved and radiated into a rich variety of species. The vertebrates also emerged from their invertebra
Externí odkaz:
https://doaj.org/article/f503f3afc36c4925ac1ec3fdbaa501cb
Autor:
Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh
Publikováno v:
eLife, Vol 5 (2016)
The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated E3 ubiquitin ligase ZNRF2
Externí odkaz:
https://doaj.org/article/22e15996b1d34e3eb9da975e48348923
Publikováno v:
Open Biology, Vol 4, Iss 5 (2014)
The complexity of signalling pathways was boosted at the origin of the vertebrates, when two rounds of whole genome duplication (2R-WGD) occurred. Those genes and proteins that have survived from the 2R-WGD—termed 2R-ohnologues—belong to families
Externí odkaz:
https://doaj.org/article/41b27477dd6f43e1b22d372b8f9d02c3
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73327 (2013)
Insulin receptor substrate 1 (IRS1) and IRS2 are well-characterized adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways. In contrast, the function of IRS4 is not well understood. IRS4 ove
Externí odkaz:
https://doaj.org/article/5d0df97bb66b467aa2d53a4789674f91
Autor:
Sabine S Neukamm, Rachel Toth, Nick Morrice, David G Campbell, Carol Mackintosh, Rainer Lehmann, Hans-Ulrich Haering, Erwin D Schleicher, Cora Weigert
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43296 (2012)
Phosphorylation of insulin receptor substrate (IRS)-2 on tyrosine residues is a key event in IGF-1/insulin signaling and leads to activation of the PI 3-kinase and the Ras/MAPK pathway. Furthermore, phosphorylated serine/threonine residues on IRS-2 c
Externí odkaz:
https://doaj.org/article/56b5e538b07547648dc5ff592c5be23c
Publikováno v:
Open Biology, Vol 2, Iss 7 (2012)
14-3-3 proteins regulate cellular responses to stimuli by docking onto pairs of phosphorylated residues on target proteins. The present study shows that the human 14-3-3-binding phosphoproteome is highly enriched in 2R-ohnologues, which are proteins
Externí odkaz:
https://doaj.org/article/cc88aa7d5d4444e583ad88727ffee75c
Autor:
Gavuthami Murugesan, Alan R. Prescott, Rachel Toth, David G. Campbell, Claire M. Wells, Carol MacKintosh
Publikováno v:
Biochemical Journal. 479:1709-1725
The protein kinases PAK4, PAK5 and PAK6 comprise a family of ohnologues. In multiple cancers including melanomas PAK5 most frequently carries non-synonymous mutations; PAK6 and PAK4 have fewer; and PAK4 is often amplified. To help interpret these gen
Autor:
Gerta Hoxhaj, Ayaz Najafov, Rachel Toth, David G. Campbell, Alan R. Prescott, Carol MacKintosh
Publikováno v:
Journal of Cell Science. 135