Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Carol M. Guarnieri"'
Publikováno v:
Journal of Clinical Oncology. 8:2054-2061
Fluorouracil (5-FU) and cisplatin display marked therapeutic synergy in preclinical models and are effective in the treatment of a number of solid tumors when combined and administered intravenously (IV). Each drug has also been administered intraper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c26b7fc8c98de3c13101878484c82ae
https://doi.org/10.1200/jco.1990.8.12.2054
https://doi.org/10.1200/jco.1990.8.12.2054
Autor:
Richard L. Schilsky, Mark J. Ratain, William R. Panje, Carol M. Guarnieri, Everett E. Vokes, Kyung E. Choi, Ralph R. Weichselbaum, D M Magid, S M Whaling
Publikováno v:
Cancer. 63:30-36
This study was designed to evaluate the safety, reliability, and patient acceptance of outpatient continuous intravenous infusion (CVI) chemotherapy. Twenty-two patients with locally advanced head and neck cancer received induction chemotherapy with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d372b65073fdd5f2695b70d79d46c7ed
https://doi.org/10.1002/1097-0142(19890101)63:1<30::aid-cncr2820630105>3.0.co
https://doi.org/10.1002/1097-0142(19890101)63:1<30::aid-cncr2820630105>3.0.co
Autor:
Susan M. Whaling, Richard L. Schilsky, Alfred Guaspari, Mary Ann Liebner, Carol M. Guarnieri, Everett E. Vokes, Kyung E. Choi
Publikováno v:
Cancer. 63:1018-1021
As part of a clinical trial of cisplatin, 5-fluorouracil (5-FU), and leucovorin (LV) for treatment of patients with advanced head and neck cancer, patients received 100 mg of LV (d,l-5-formyltetrahydrofolate) orally every 4 hours for 5 days. On days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcfb13178198a8543c3191052547037f
https://doi.org/10.1002/1097-0142(19890315)63:6+<1018::aid-cncr2820631305>3.0.co
https://doi.org/10.1002/1097-0142(19890315)63:6+<1018::aid-cncr2820631305>3.0.co
Autor:
Everett E. Vokes, Richard L. Schilsky, Carol M. Guarnieri, Ralph R. Weichselbaum, Susan M. Whaling, Alfred Guaspari, William R. Panje
Publikováno v:
Cancer. 63:1048-1053
Both cisplatin and leucovorin may increase the activity of 5-fluorouracil (5-FU) by increasing the intracellular concentration of reduced folates. Therefore, a Phase I study was conducted in patients with recurrent or metastatic head and neck cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aaca042d6889e62733770671b2eb10e
https://doi.org/10.1002/1097-0142(19890315)63:6+<1048::aid-cncr2820631311>3.0.co
https://doi.org/10.1002/1097-0142(19890315)63:6+<1048::aid-cncr2820631311>3.0.co
Autor:
Richard L. Schilsky, Mary Ann Liebner, Elizabeth K. Senekjian, Nicholas J. Vogelzang, Mark J. Ratain, Carol M. Guarnieri, Kyung E. Choi, Dale Grimmer
Publikováno v:
Clinical Pharmacology and Therapeutics. 45:226-233
We sought to use a previously derived pharmacodynamic model for 72-hour etoposide infusions to adaptively control administration of this agent and to demonstrate that more predictable toxicity could be obtained with this dosing scheme. A randomized c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60adc162cc1d5a7fb597d5ea4846372
https://doi.org/10.1038/clpt.1989.22
https://doi.org/10.1038/clpt.1989.22
Autor:
Ralph R. Weichselbaum, William J. Moran, Everett E. Vokes, Carol M. Guarnieri, Richard L. Schilsky, Kyung E. Choi, William R. Panje
Publikováno v:
Journal of Clinical Oncology. 6:618-626
We added high-dose oral leucovorin to the combination of cisplatin and fluorouracil (5-FU) to assess the efficacy of this regimen in the treatment of patients with head and neck cancer. Cisplatin, 100 mg/m2, was followed by a 5-FU continuous infusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8567aa4baac66845fb7ab5ff58237983
https://doi.org/10.1200/jco.1988.6.4.618
https://doi.org/10.1200/jco.1988.6.4.618
Autor:
William R. Panje, Everett E. Vokes, Azhar Awan, Ralph R. Weichselbaum, Carol M. Guarnieri, William J. Moran, Richard L. Schilsky
Publikováno v:
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 98(4)
We tested the combination of hydroxyurea (HU), 5-fluorouracil (5-FU), and concomitant radiotherapy (XRT) in a group of patients with advanced or recurrent head and neck cancer. Both drugs are effective single agents, have shown synergistic activity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d97124dbff30254022efc3852aa7a2
https://pubmed.ncbi.nlm.nih.gov/3132681
https://pubmed.ncbi.nlm.nih.gov/3132681
Autor:
Susan M. Whaling, Carol M. Guarnieri, D M Magid, Richard L. Schilsky, Everett E. Vokes, William R. Panje, Ralph R. Weichselbaum
Publikováno v:
Selective cancer therapeutics. 5(3)
This study was designed to test whether previously untreated patients with head and neck cancer could effectively manage home continuous infusion chemotherapy, and to compare their acceptance and adjustment to home versus inpatient treatment. Twenty-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44d24373956221e8c8ba36e1e845ebd
https://pubmed.ncbi.nlm.nih.gov/2682877
https://pubmed.ncbi.nlm.nih.gov/2682877