Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Carol M, Troy"'
Autor:
Elodie Bosc, Julie Anastasie, Feryel Soualmia, Pascale Coric, Ju Youn Kim, Lily Q. Wang, Gullen Lacin, Kaitao Zhao, Ronak Patel, Eric Duplus, Philippe Tixador, Andrew A. Sproul, Bernard Brugg, Michelle Reboud-Ravaux, Carol M. Troy, Michael L. Shelanski, Serge Bouaziz, Michael Karin, Chahrazade El Amri, Etienne D. Jacotot
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-14 (2022)
Abstract Caspase-2 (Casp2) is a promising therapeutic target in several human diseases, including nonalcoholic steatohepatitis (NASH) and Alzheimer’s disease (AD). However, the design of an active-site-directed inhibitor selective to individual cas
Externí odkaz:
https://doaj.org/article/e2ca2ef1c4d34003bb95c448c8eb4433
Autor:
Crystal Colón Ortiz, Albertine M. Neal, Maria I. Avrutsky, Monica Choi, Jade Smart, Jacqueline Lawson, Carol M. Troy
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-14 (2022)
Abstract Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs. Neurovascular injuries damage homeostatic communication between endothelial, pericyte, glial, and neuronal cells through si
Externí odkaz:
https://doaj.org/article/e598917a3cdc4f85bc46a273c7bcb3e0
Autor:
Maria I. Avrutsky, Claire W. Chen, Jacqueline M. Lawson, Scott J. Snipas, Guy S. Salvesen, Carol M. Troy
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
PurposeRetinal vein occlusion (RVO) is a sight-threatening condition typically treated with intravitreal injection of vascular endothelial growth factor (VEGF) antagonists. Treatment response to anti-VEGF therapies is highly variable, with poor visua
Externí odkaz:
https://doaj.org/article/343ce8dd0fbf4bde92bc9cbfe8a8de51
Autor:
Osama Al-Dalahmah, Alexander A. Sosunov, Yu Sun, Yang Liu, Nacoya Madden, E. Sander Connolly, Carol M. Troy, Guy M. McKhann, James E. Goldman
Publikováno v:
Cells, Vol 13, Iss 2, p 129 (2024)
In the mammalian isocortex, CD44, a cell surface receptor for extracellular matrix molecules, is present in pial-based and fibrous astrocytes of white matter but not in protoplasmic astrocytes. In the hominid isocortex, CD44+ astrocytes comprise the
Externí odkaz:
https://doaj.org/article/ca845e2049f9456694582ee77233a2d0
Autor:
Maria I. Avrutsky, Crystal Colón Ortiz, Kendra V. Johnson, Anna M. Potenski, Claire W. Chen, Jacqueline M. Lawson, Alexandra J. White, Stephanie K. Yuen, Fatima N. Morales, Elisa Canepa, Scott Snipas, Guy S. Salvesen, Ying Y. Jean, Carol M. Troy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Retinal vein occlusion can cause blindness, and features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here the authors report a non-apoptotic role of endothelial caspase-9 in regulating blood-retina barrier integrity and ne
Externí odkaz:
https://doaj.org/article/4688da8d4e524bccb33f889dc5ad0823
Autor:
Crystal Colón Ortiz, Albertine M. Neal, Maria I. Avrutsky, Monica Choi, Jade Smart, Jacqueline Lawson, Carol M. Troy
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/8d396523c1754dd5bd01322fc6045609
Autor:
Maria I. Avrutsky, Carol M. Troy
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue degeneration. Its nonapoptotic functions, including regulation of cellular differentiation/m
Externí odkaz:
https://doaj.org/article/f06e25f038e64c1396b753c7a8b320c7
Autor:
Laura E. Montroull, Deborah E. Rothbard, Hur D. Kanal, Veera D’Mello, Vincent Dodson, Carol M. Troy, Juan P. Zanin, Steven W. Levison, Wilma J. Friedman
Publikováno v:
ASN Neuro, Vol 12 (2020)
The p75 neurotrophin receptor (p75NTR) can regulate multiple cellular functions including proliferation, survival, and apoptotic cell death. The p75NTR is widely expressed in the developing brain and is downregulated as the nervous system matures, wi
Externí odkaz:
https://doaj.org/article/92e8ef812bea452d99d548462c7f6eb8
Autor:
Osama Al Dalahmah, Alexander A Sosunov, Yu Sun, Yang Liu, Nsikan Akpan, Nacoya Madden, E. Sander Connolly, Carol M Troy, Guy M McKhann II, James E. Goldman
In the mammalian isocortex CD44, a cell surface receptor for extracellular matrix molecules, is present in pial-based and fibrous astrocytes of white matter, but not the protoplasmic astrocytes. In the hominid isocortex, CD44+ astrocytes comprise the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b82a7322a154658fbae17ef138beaa
Autor:
Maria I. Avrutsky, Crystal Colón Ortiz, Kendra V. Johnson, Anna M. Potenski, Claire W. Chen, Jacqueline M. Lawson, Alexandra J. White, Stephanie K. Yuen, Fatima N. Morales, Elisa Canepa, Scott Snipas, Guy S. Salvesen, Ying Y. Jean, Carol M. Troy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/3967406557774ccfbdefb75fc3e62a7e