Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Carol Lange"'
Autor:
Andrew Takchi, Minzhi Zhang, Mohammad Jalalirad, Roberto Leon Ferre, Royal Shrestha, Tufia Haddad, Jann Sarkaria, Ann Tuma, Jodi Carter, Hillman David, Karthik Giridhar, Liewei Wang, Carol Lange, Urban Lendahl, James Ingle, Matthew Goetz, Antonino Bonaventura D’Assoro
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Triple negative breast cancer (TNBC) accounts for 15–20% of all breast cancers and mainly affects pre-menopausal and minority women. Because of the lack of ER, PR or HER2 expression in TNBC, there are limited options for tailored therapies. While T
Externí odkaz:
https://doaj.org/article/ef71d4b2bfbb4846b7a7d75ed4097563
Autor:
Mateusz Opyrchal, Jeffrey L Salisbury, Shuya Zhang, James McCubrey, John Hawse, Mattew P Goetz, Gwen A Lomberk, Tufia Haddad, Amy Degnim, Carol Lange, James N Ingle, Evanthia Galanis, Antonino B D'Assoro
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96995 (2014)
Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the underlying mechanisms are st
Externí odkaz:
https://doaj.org/article/c7da98dd6ce74f7c926be89deef9be93
Autor:
Meritxell Bellet, Serafin Morales, Ariadna Gasol, Kepa Amillano, Nuria Chic, Xavier González-Farré, Patricia Villagrasa, Laia Paré, Claudette Falato, Paolo Nuciforo, Débora Martínez, Juan M Ferrero-Cafiero, Tomás Pascual, Aleix Prat, Carol Lange, Cristina Saura
Publikováno v:
Cancer Research. 82:P1-07
Background PgR expression is a biomarker of ER functionality, cellular progression to malignancy, and response to endocrine therapy (ET) in HR+ BC. Onapristone (ONA), a type 1 antiprogestin, was shown to have a single agent anti-tumor activity in pat
Autor:
Sailaja Kamaraju, Amy Fowler, Chung Yee Cheng, Lubna N Chaudhary, John Burfeind, Janet Retseck, Amye J Tevaarwerk, Mark Burkard, Elisavet Paplomata, Amanda M Parkes, Julie M Jorns, Sergey Tarima, Douglas Yee, Hallgeir Rui, Carol Lange, Tarek Sahmoud, Kari B Wisinski
Publikováno v:
Cancer Research. 82:OT2-16
Background Antiprogestins, including selective progesterone receptor (PgR) modulators (SPRMs) that act as PgR antagonists, are a promising class of therapeutics for overcoming endocrine resistance including in patients who develop activating estrogen
Autor:
Elizabeth Benner, Camila Dos Santos, Kyla Hagen, Carol Lange, Julie Ostrander, Nuri Temiz, Marygrace Trousdell, Thu Truong
Publikováno v:
Journal of the Endocrine Society. 6:A879-A880
Recurrence of metastatic breast cancer stemming from acquired endocrine and chemotherapy resistance remains a health burden for women with luminal (ER+) breast cancer. ER+ tumor cells can remain viable but quiescent for years to decades. Contributing
Autor:
Yao Shen, Jasvinder Singh, Bindeshwar Sah, Zhongming Chen, Wootae Ha, Christine Henzler, Tao Su, Lilian Xie, Yibin Deng, Gen Li, Hua Guo, Carol Lange, Hanina Hibshoosh, Liang Liu
The hairless (HR) gene encodes a transcription factor with histone demethylase activity that is essential for development and tissue homeostasis. Previous studies suggest that mutational inactivation of HR promotes tumorigenesis. To investigate HR mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff33b76d4fba6dcf107c5e27b19c22c8
https://doi.org/10.21203/rs.3.rs-1639413/v1
https://doi.org/10.21203/rs.3.rs-1639413/v1
Autor:
Sailaja Kamaraju, Amy Fowler, Lubna N. Chaudhary, Mark Burkard, Thomas Giever, Robert N Hegeman, Michele Pipp-Dahm, Yee Chung Cheng, Carol Lange, Julie M. Jorns, Amy Stella, Nauman Siddiqui, Luke Zurbriggen, Saurabh Rajguru, Sergey Tarima, Deepika Sriram, Janet Retseck, Hallgeir Rui, Tarek Sahmoud, Kari B. Wisinski
Publikováno v:
Cancer Research. 83:OT2-01
Background Antiprogestins, including selective progesterone receptor (PgR) modulators (SPRMs) that act as PgR antagonists, are a promising class of therapeutics for overcoming endocrine resistance including in patients who develop activating estrogen
Autor:
Jianxun Lei, Zhijun Guo, Julissa Molina-Vega, Paloma Cervantes, Swaathi Jayaraman, John R. Hawse, Carlos Perez, Juan Abrahante, Xiaojia Tang, Krishna Kalari, Jinhua Wang, John R. Falck, Carol Lange, Matthew P. Goetz, David Potter
Publikováno v:
Cancer Research. 82:LB564-LB564
While epoxyeicosatrienoic acids (EETs) have been implicated in breast cancer growth and progression, less is known about their effects on oncogene transcription. We have previously found that the oncogenic regioisomer (±)14,15-EET drives mitochondri
Publikováno v:
American Journal of Botany. 98:1956-1965
Premise of the study Plant communities may be influenced by toxic secondary metabolites or enhanced plant growth from plant-symbiont interactions. The C:N hypothesis predicts that carbon or nitrogen constrains plant secondary metabolite production, b