Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Carol L. Svatek"'
Autor:
Debao Lu, Hayder H. Al-Azzawi, Deborah A. Swartz-Basile, James M. Kiely, Henry A. Pitt, Shannon J. Graewin, Carol L. Svatek
Publikováno v:
Journal of the American College of Surgeons. 206:503-510
Little is known about the genetic factors that cause alterations in gallbladder motility, cholesterol crystal nucleation, biliary lipids, and, ultimately, cholesterol gallstones. Obese, leptin-deficient (Lep(ob)) mice have large gallbladder volumes w
Publikováno v:
Journal of Surgical Research. 130:146-151
Background Obesity and diabetes are major risk factors for cholesterol gallstones, and the majority of obese people are leptin-resistant. Our previous work has shown that both leptin-deficient (Lepob) and leptin-resistant (Lepdb) obese diabetic mice
Autor:
Matthew I. Goldblatt, Carol L. Svatek, Khoi Q. Tran, Keun Ho Lee, Henry A. Pitt, Attila Nakeeb, Shannon J. Graewin
Publikováno v:
Journal of Surgical Research. 122:145-149
Introduction: Human obesity is associated with leptin resistance, elevated serum lipids, hepatic steatosis, and cholesterol gallstone formation. We have previously demonstrated that leptin-resistant (Lepdb) obese mice fed a low cholesterol diet have
Autor:
James M. Kiely, Keun-Ho Lee, Henry A. Pitt, Shannon J. Graewin, Attila Nakeeb, Carol L. Svatek
Publikováno v:
Journal of Gastrointestinal Surgery. 8:824-830
Diabetes and obesity are strongly associated and are risk factors for cholesterol gallstone disease. Leptinde ficient and leptin-resistant diabetic obese mice have enlarged, hypomotile gallbladders. In addition, bile from gallbladders of leptin-defic
Autor:
Henry A. Pitt, Attila Nakeeb, Shannon J. Graewin, Carol L. Svatek, Keun Ho Lee, James M. Kiely
Publikováno v:
Surgery. 136:431-436
Background. Obesity is associated with diabetes and gallstone formation. Obese leptin-deficient (Lep ab ) and leptin-resistant (Lep db ) mice are hyperglycemic and have enlarged gallbladders with diminished response in vitro to cholecystokinin (CCK)
Autor:
Khoi Q. Tran, Shannon J. Graewin, Deborah A. Swartz-Basile, Henry A. Pitt, Carol L. Svatek, Attila Nakeeb
Publikováno v:
Surgery. 134:372-377
Background. Human obesity is associated with leptin resistance, elevated serum glucose and lipids, hepatic steatosis, and cholesterol gallstone formation. These gallstones are thought to result from hypersecretion of biliary cholesterol as well as bi
Publikováno v:
Journal of pediatric surgery. 41(7)
Background Residual bowel increases absorption after massive small bowel resection. Leptin affects intestinal adaptation, carbohydrate, peptide, and lipid handling. Sucrase, peptidase, and acyl coenzyme A:monoacylglycerol acyltransferase (MGAT) are i
Publikováno v:
The Journal of surgical research. 130(1)
Obesity and diabetes are major risk factors for cholesterol gallstones, and the majority of obese people are leptin-resistant. Our previous work has shown that both leptin-deficient (Lepob) and leptin-resistant (Lepdb) obese diabetic mice have decrea
Autor:
Shannon J, Graewin, Keun-Ho, Lee, Khoi Q, Tran, Matthew I, Goldblatt, Carol L, Svatek, Attila, Nakeeb, Henry A, Pitt
Publikováno v:
The Journal of surgical research. 122(2)
Human obesity is associated with leptin resistance and cholesterol gallstone formation. Previously, we demonstrated that leptin-resistant (Lep(db)) obese mice fed a low cholesterol diet have enlarged gallbladders, but a decreased cholesterol saturati
Autor:
Atilla Nakeeb, Carol L. Svatek, Henry A. Pitt, Matthew I. Goldblatt, Deborah A. Swartz-Basile
Publikováno v:
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 6(3)
Obesity is a major risk factor for gallstone formation, but the pathogenesis of this phenomenon remains unclear. Human data on gallbladder emptying are conflicting, and no animal data exist on the effect of obesity on gallbladder motility. Leptin, a