Výsledky vyhledávání - "Carol L. MacLeod"

Data from Molecular Characterization of the Transition to Malignancy in a Genetically Engineered Mouse-Based Model of Ductal Carcinoma In situ1

Autor: Jeffrey P. Gregg, Carol L. MacLeod, Robert D. Cardiff, Alexander D. Borowsky, Lawrence J.T. Young, Jeannie E. Maglione, Ruria Namba

A transplantable model of human ductal carcinoma in situ that progresses to invasive carcinoma was developed from a genetically engineered mouse (GEM). Additional lines were established using early mammary premalignant lesions from transgenic MMTV-Py

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1726ed2fcaebb670db06c01a643bf8
https://doi.org/10.1158/1541-7786.c.6543052.v1

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Rapamycin Inhibits Growth of Premalignant and Malignant Mammary Lesions in a Mouse Model of Ductal Carcinoma In situ

Autor: Ruria Namba, Craig K. Abbey, Robert D. Cardiff, Jeffrey P. Gregg, Lawrence J. T. Young, Alexander D. Borowsky, Carol L. MacLeod, Clifford G. Tepper, Jinyi Qi, Lisa Kim, Patrizia Damonte

Publikováno v: Clinical Cancer Research. 12:2613-2621

Purpose: Rapamycin has been shown to have antitumor effects in various tumor models. To study the effect of rapamycin at different stages of breast cancer development, we used two unique mouse models of breast cancer with activated phosphatidylinosit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a821ac5315e003514b4f2f0d2578c8
https://doi.org/10.1158/1078-0432.ccr-05-2170

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Molecular Characterization of the Transition to Malignancy in a Genetically Engineered Mouse-Based Model of Ductal Carcinoma In situ

Autor: Ruria Namba, Jeannie E. Maglione, Lawrence J.T. Young, Alexander D. Borowsky, Robert D. Cardiff, Carol L. MacLeod, Jeffrey P. Gregg

Publikováno v: Molecular Cancer Research. 2:453-463

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a43a2ec6f54314450eba77b8a150acef
https://doi.org/10.1158/1541-7786.453.2.8

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Polyomavirus middle T–induced mammary intraepithelial neoplasia outgrowths: Single origin, divergent evolution, and multiple outcomes

Autor: Jeannie E. Maglione, Erik T. McGoldrick, Lawrence J.T. Young, Ruria Namba, Jeffrey P. Gregg, Lin Liu, Drew Moghanaki, Lesley G. Ellies, Alexander D. Borowsky, Robert D. Cardiff, Carol L. MacLeod

Publikováno v: Molecular Cancer Therapeutics. 3:941-953

The development of models to investigate the pathobiology of premalignant breast lesions is a critical prerequisite for development of breast cancer prevention and early intervention strategies. Using tissue transplantation techniques, we modified th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e92117af4ff10bd5989892cc5928931f
https://doi.org/10.1158/1535-7163.941.3.8

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Interferon-γ regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways

Autor: Manuel Modolell, Maria Serra, Carol L. MacLeod, Concepció Soler, Antonio Celada, Marçal Pastor-Anglada, Jose Manuel Garcia-Manteiga, Elena Guillén-Gómez, F. Javier Casado, Antonio Felipe

Publikováno v: Biochemical Journal. 375:777-783

The expressions of CNT and ENT (concentrative and equilibrative nucleoside transporters) in macrophages are differentially regulated by IFN-gamma (interferon-gamma). This cytokine controls gene expression through STAT1-dependent and/or -independent p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeaed1a2beb62cf46332b8ca8c766f6
https://doi.org/10.1042/bj20030260

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Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase

Autor: Lesley G. Ellies, Michael Fishman, Carol L. MacLeod, Jeanine Kleeman, Robert D. Cardiff, Joy Hardison, Cathyryne K. Manner, Jeannie E. Maglione

Publikováno v: International Journal of Cancer. 106:1-7

Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fce9a602c6e2a89a5fa36aebffc7bef
https://doi.org/10.1002/ijc.11178

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CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes

Autor: Carol L. MacLeod, Benjamin Nicholson, Cathyryne K. Manner

Publikováno v: Journal of Neurochemistry. 85:476-482

We have previously demonstrated that genetic ablation of cationic amino acid transporter 2 (Cat2) significantly inhibits nitric oxide (NO) production by inducible nitric oxide synthase (iNOS) in activated macrophages. Here we report that iNOS activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f7dfb42c932de3d3f9523a3b47c2a9b
https://doi.org/10.1046/j.1471-4159.2003.01695.x

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