Supplementary Figures 1 - 6 from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Autor: Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian

PDF file - 348KB, Figure S1: Isogenic IDH1 mutation compromises metabolic reprogramming under hypoxia. Figure S2: Simulated and measured uncorrected MIDs. Figure S3: Compromised Reductive TCA Metabolism is specific to cells with mutant IDH1. Figure S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376c269450e5947866e21be024083aa0
https://doi.org/10.1158/0008-5472.22404444

Supplementary Methods, Figure Legends from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Autor: Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian

PDF file - 136KB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c83526185c0fd14582306beb658d0d3
https://doi.org/10.1158/0008-5472.22404441.v1

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Autor: Erika Handly, Joseph D. Growney, Kelly Slocum, Anne N. Murphy, Courtney R. Green, Fallon Lin, Xiamei Zhang, Christian M. Metallo, Seth J. Parker, Chad Vickers, Christopher Straub, Alexandra R. Grassian, Matthew G. Vander Heiden, Raymond Pagliarini, Minying Pu, Ajit S. Divakaruni, Carol Joud-Caldwell, Franklin Chung, Hong Yin, Shawn M. Davidson

Publikováno v: Cancer research, vol 74, iss 12
Grassian, AR; Parker, SJ; Davidson, SM; Divakaruni, AS; Green, CR; Zhang, X; et al.(2014). IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Research, 74(12), 3317-3331. doi: 10.1158/0008-5472.CAN-14-0772-T. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/69g6m263
PMC

Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed 13C metabolic flux analysis on a panel of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82569fd8ce5f50271577681b756aaef
https://doi.org/10.1158/0008-5472.can-14-0772-t

Abstract B159: Heterozygous IDH1 mutations modify the citric acid (TCA) cycle metabolism and sensitize cells to inhibition of mitochondrial respiration/oxidative phosphorylation

Autor: Hong Yin, Alexandra R. Grassian, Courtney R. Green, Raymond Pagliarini, Seth J. Parker, Fallon Lin, Christopher Sean Straub, Shawn M. Davidson, Franklin Chung, Christian M. Metallo, Matthew Vander Heiden, Carol Joud-Caldwell

Publikováno v: Molecular Cancer Therapeutics. 12:B159-B159

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a variety of tumor types. Although these mutations are loss-of-function for conversion of isocitrate to α-ketoglutarate, the mutant enzymes greatly increase the production of the propos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b0c570c4ab0a291aec74777bc67dedc
https://doi.org/10.1158/1535-7163.targ-13-b159