Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Carol Joud"'
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 348KB, Figure S1: Isogenic IDH1 mutation compromises metabolic reprogramming under hypoxia. Figure S2: Simulated and measured uncorrected MIDs. Figure S3: Compromised Reductive TCA Metabolism is specific to cells with mutant IDH1. Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376c269450e5947866e21be024083aa0
https://doi.org/10.1158/0008-5472.22404444
https://doi.org/10.1158/0008-5472.22404444
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 93KB, Estimates Fluxes for HCT116 Parental and IDH1 R132H/+ 2H1 cells under Normoxia and Hypoxia (2 percent Oxygen).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b28b49cb8efffcec5890dedaa06d63
https://doi.org/10.1158/0008-5472.22404438
https://doi.org/10.1158/0008-5472.22404438
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 136KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c83526185c0fd14582306beb658d0d3
https://doi.org/10.1158/0008-5472.22404441.v1
https://doi.org/10.1158/0008-5472.22404441.v1
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed 13C metabolic flux analysis on a panel of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e49274eaaaa28fa6411ec05c17088e
https://doi.org/10.1158/0008-5472.c.6506604.v1
https://doi.org/10.1158/0008-5472.c.6506604.v1
Autor:
Subarna Shakya, José S. Duca, Elizabeth R. Sprague, Xin Chen, Zhuoliang Chen, Carol Joud, Yaping Wang, John William Giraldes, Wenlin Shao, Simon Mathieu, Chen Christine Hiu-Tung, Yanqiu Yuan, Kristen Hurov, B. Barry Touré, Christopher Sean Straub
Publikováno v:
Journal of Medicinal Chemistry. 60:2155-2161
While adding the structural features that are more favored by on-target activity is the more common strategy in selectivity optimization, the opposite strategy of subtracting the structural features that contribute more to off-target activity can als
Autor:
Erika Handly, Joseph D. Growney, Kelly Slocum, Anne N. Murphy, Courtney R. Green, Fallon Lin, Xiamei Zhang, Christian M. Metallo, Seth J. Parker, Chad Vickers, Christopher Straub, Alexandra R. Grassian, Matthew G. Vander Heiden, Raymond Pagliarini, Minying Pu, Ajit S. Divakaruni, Carol Joud-Caldwell, Franklin Chung, Hong Yin, Shawn M. Davidson
Publikováno v:
Cancer research, vol 74, iss 12
Grassian, AR; Parker, SJ; Davidson, SM; Divakaruni, AS; Green, CR; Zhang, X; et al.(2014). IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Research, 74(12), 3317-3331. doi: 10.1158/0008-5472.CAN-14-0772-T. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/69g6m263
PMC
Grassian, AR; Parker, SJ; Davidson, SM; Divakaruni, AS; Green, CR; Zhang, X; et al.(2014). IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Research, 74(12), 3317-3331. doi: 10.1158/0008-5472.CAN-14-0772-T. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/69g6m263
PMC
Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed 13C metabolic flux analysis on a panel of
Autor:
Dale Porter, Lawrence Blas Perez, Kymberly Levine, Walter Michael, Catherine Fiorilla, Michael Dore, Raviraj Kulathila, Kara Herlihy, Michael Scott Visser, Simon van der Plas, Dipietro Lucian, Michael A Mcewan, Clayton Springer, Xiaoling Xie, Francois Lenoir, Karen Miller-Moslin, Madelene Y. Hoe, B. Barry Touré, Naeem Yusuff, Rajesh Karki, John Sullivan, Carol Joud
Overexpression of the antiapoptotic members of the Bcl-2 family of proteins is commonly associated with cancer cell survival and resistance to chemotherapeutics. Here, we describe the structure-based optimization of a series of N-heteroaryl sulfonami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175a4571a176ef8fb09f300f0c02b1fa
https://europepmc.org/articles/PMC4027142/
https://europepmc.org/articles/PMC4027142/
Autor:
Dale Porter, Michael Dore, Carol Joud, Michael Scott Visser, B. Barry Touré, Clayton Springer, Naeem Yusuff, Xiaoling Xie, Kara Herlihy
Publikováno v:
ACS medicinal chemistry letters. 3(7)
The discovery of new Bcl-2 protein–protein interaction antagonists is described. We replaced the northern fragment of ABT737 (π–π stacking interactions) with structurally simplified hydrophobic cage structures with much reduced conformational f
Autor:
Kelly Slocum, Anne N. Murphy, Chad Vickers, Seth J. Parker, Christopher Sean Straub, Franklin Chung, Alexandra R. Grassian, Minying Pu, Erika Handly, Fallon Lin, Raymond Pagliarini, Ajit S. Divakaruni, Christian M. Metallo, Xiamei Zhang, Hong Yin, Matt Vander Heiden, Carol Joud-Caldwell, Joseph D. Growney, Shawn M. Davidson, Courtney R. Green
Publikováno v:
Cancer Research. 74:LB-139
Mutations in the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a variety of tumor types, resulting in production of the proposed oncometabolite, 2-hydroxyglutarate (2-HG). How mutant IDH alters central carbon metabolism, though, r
Autor:
Hong Yin, Alexandra R. Grassian, Courtney R. Green, Raymond Pagliarini, Seth J. Parker, Fallon Lin, Christopher Sean Straub, Shawn M. Davidson, Franklin Chung, Christian M. Metallo, Matthew Vander Heiden, Carol Joud-Caldwell
Publikováno v:
Molecular Cancer Therapeutics. 12:B159-B159
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a variety of tumor types. Although these mutations are loss-of-function for conversion of isocitrate to α-ketoglutarate, the mutant enzymes greatly increase the production of the propos