Výsledky vyhledávání - "Carol J. Dragland"

Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase

Publikováno v: Journal of Medicinal Chemistry. 43:236-249

N‘-Methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC50 = 180 μM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a21921472d2095e7c5eea09d6d92805
https://doi.org/10.1021/jm990358+

Zobrazit plný text záznamu

(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase

Publikováno v: Journal of Medicinal Chemistry. 42:2741-2746

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d109ec966714cd20d37ebc973dd61
https://doi.org/10.1021/jm9902584

Zobrazit plný text záznamu

Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits ATP-dependent inactivation of pyruvate dehydrogenase complex

Autor: Bing Yan, Sid Topiol, Thomas Daniel Aicher, Carol J. Dragland, Vijayayakumar Sundararajan, John C. Jackson, William R. Mann, John E. Blume, Philip A. Bell, Paul Ramage, Christine C. Vinluan, John S. Gounarides, N. R. Nirmala

Publikováno v: Biochemical Journal. 334:703-711

The activity of the pyruvate dehydrogenase multienzyme complex (PDC), which catalyses the oxidation of pyruvate to acetyl-CoA within the mitochondrion, is diminished in animal models of diabetes. Studies with purified PDC components have suggested th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::405c028ae9929d1cb5f403e9247ed185
https://doi.org/10.1042/bj3340703

Zobrazit plný text záznamu

Kinetic, Circular Dichroism and Fluorescence Studies on Heterologously Expressed Carnitine Palmitoyltransferase II

Autor: Carol J. Dragland, William R. Mann, Philip A. Bell, Bing Yan

Publikováno v: Journal of Enzyme Inhibition. 9:303-308

Km estimates for carnitine and palmitoyl-CoA of heterologously expressed rat liver carnitine palmitoyl-transferase-II (rCPT-II) were 950 +/- 27 microM and 34 +/- 6 microM, respectively. Vmax for the enzyme was 1.8 mumol/min/mg purified protein. Consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd8d2e35893554780839c6cc36fb6b2
https://doi.org/10.3109/14756369509036559

Zobrazit plný text záznamu

Diverse mechanisms of inhibition of pyruvate dehydrogenase kinase by structurally distinct inhibitors

Autor: Carol J. Dragland, William R. Mann, Philip A. Bell, T.R Vedananda, Thomas Daniel Aicher, Christine C. Vinluan

Publikováno v: Biochimica et biophysica acta. 1480(1-2)

The mechanism of action of structurally distinct pyruvate dehydrogenase kinase (PDK) inhibitors was examined in assays with experimental contexts ranging from an intact pyruvate dehydrogenase complex (PDC) with and without supplemental ATP or ADP to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409b5e166d22171d1c1e527822433cb6
https://pubmed.ncbi.nlm.nih.gov/11004568

Zobrazit plný text záznamu

Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase

Publikováno v: Journal of medicinal chemistry. 43(11)

The optimization of a series of anilide derivatives of (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9230c1ef002859de18c4f7fe1f8ef950
https://pubmed.ncbi.nlm.nih.gov/10841803

Zobrazit plný text záznamu

Over-expression and characterization of active recombinant rat liver carnitine palmitoyltransferase II using baculovirus

Autor: R C Anderson, William R. Mann, T M Johnson, Carol J. Dragland, Philip A. Bell, G M Nemecek

Publikováno v: The Biochemical journal. 309

The cDNA encoding rat liver carnitine palmitoyltransferase II (CPT-II) was heterologously expressed using a recombinant baculovirus/insect cell system. Unlike Escherichia coli, the baculovirus-infected insect cells expressed mostly soluble active rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf5f84a6c0489c873e15f8e0ff78894
https://pubmed.ncbi.nlm.nih.gov/7626037

Zobrazit plný text záznamu

Insulin-induced increases in the activity of the spontaneously active and ATP.Mg-dependent forms of phosphatase-1 in alloxan-diabetic rat liver

Autor: Carol J. Dragland-Meserve, Lynne H. Parker Botelho, Donald K. Webster

Publikováno v: European journal of biochemistry. 146(3)

Liver supernatant from normal and alloxan-diabetic rats was fractionated by DEAE-cellulose chromatography and the separated phosphoprotein phosphatase fractions were assayed with [32P]histone f2b, [32P]phosphorylase a and [32P]phosphorylase kinase as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d732d7d93583dd33eef77a18833ecf11
https://pubmed.ncbi.nlm.nih.gov/2982604

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání