Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Carol J. Dragland"'
Autor:
Gary M. Coppola, Xilin Liu, Robert C. Anderson, Douglas C. Knorr, William S. Fillers, James L. Stanton, Jiaping Gao, Tomaselli Hc, Christine C. Vinluan, Thomas Daniel Aicher, Carol J. Dragland, Suraj S. Shetty, Wieslawa Maniara, A. Islam, Emma L. Kaplan, William R. Mann, Leonard J. Brand, Donald Mark Sperbeck, R. E. Walter, Dominick DelGrande, R. J. Lozito
Publikováno v:
Journal of Medicinal Chemistry. 43:236-249
N‘-Methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC50 = 180 μM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a21921472d2095e7c5eea09d6d92805
https://doi.org/10.1021/jm990358+
https://doi.org/10.1021/jm990358+
Autor:
Emma L. Kaplan, Gary M. Coppola, Xilin Liu, Gregory Raymond Bebernitz, Donald Mark Sperbeck, Dominick DelGrande, Wieslawa Maniara, Leonard J. Brand, Suraj S. Shetty, Thomas Daniel Aicher, Robert C. Anderson, Charles F. Jewell, R. J. Lozito, Douglas C. Knorr, A. Islam, Chen Liu, Christine C. Vinluan, Jianping Gao, Robert J. Strohschein, William R. Mann, Carol J. Dragland, R. E. Walter
Publikováno v:
Journal of Medicinal Chemistry. 42:2741-2746
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d109ec966714cd20d37ebc973dd61
https://doi.org/10.1021/jm9902584
https://doi.org/10.1021/jm9902584
Autor:
Bing Yan, Sid Topiol, Thomas Daniel Aicher, Carol J. Dragland, Vijayayakumar Sundararajan, John C. Jackson, William R. Mann, John E. Blume, Philip A. Bell, Paul Ramage, Christine C. Vinluan, John S. Gounarides, N. R. Nirmala
Publikováno v:
Biochemical Journal. 334:703-711
The activity of the pyruvate dehydrogenase multienzyme complex (PDC), which catalyses the oxidation of pyruvate to acetyl-CoA within the mitochondrion, is diminished in animal models of diabetes. Studies with purified PDC components have suggested th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::405c028ae9929d1cb5f403e9247ed185
https://doi.org/10.1042/bj3340703
https://doi.org/10.1042/bj3340703
Publikováno v:
Journal of Enzyme Inhibition. 9:303-308
Km estimates for carnitine and palmitoyl-CoA of heterologously expressed rat liver carnitine palmitoyl-transferase-II (rCPT-II) were 950 +/- 27 microM and 34 +/- 6 microM, respectively. Vmax for the enzyme was 1.8 mumol/min/mg purified protein. Consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd8d2e35893554780839c6cc36fb6b2
https://doi.org/10.3109/14756369509036559
https://doi.org/10.3109/14756369509036559
Autor:
Carol J. Dragland, William R. Mann, Philip A. Bell, T.R Vedananda, Thomas Daniel Aicher, Christine C. Vinluan
Publikováno v:
Biochimica et biophysica acta. 1480(1-2)
The mechanism of action of structurally distinct pyruvate dehydrogenase kinase (PDK) inhibitors was examined in assays with experimental contexts ranging from an intact pyruvate dehydrogenase complex (PDC) with and without supplemental ATP or ADP to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409b5e166d22171d1c1e527822433cb6
https://pubmed.ncbi.nlm.nih.gov/11004568
https://pubmed.ncbi.nlm.nih.gov/11004568
Autor:
Wei H. Wang, Christine C. Vinluan, Robert J. Strohschein, Xilin Liu, Emma L. Kaplan, Dominick DelGrande, Gregory Raymond Bebernitz, Douglas C. Knorr, Jennifer Tan, Jiaping Gao, Suraj S. Shetty, James L. Stanton, Charles Liu, Thomas Daniel Aicher, Carol J. Dragland, William R. Mann, Leonard J. Brand, Robert J. Lozito, Wieslawa Maniara, Amin Islam
Publikováno v:
Journal of medicinal chemistry. 43(11)
The optimization of a series of anilide derivatives of (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9230c1ef002859de18c4f7fe1f8ef950
https://pubmed.ncbi.nlm.nih.gov/10841803
https://pubmed.ncbi.nlm.nih.gov/10841803
Publikováno v:
The Biochemical journal. 309
The cDNA encoding rat liver carnitine palmitoyltransferase II (CPT-II) was heterologously expressed using a recombinant baculovirus/insect cell system. Unlike Escherichia coli, the baculovirus-infected insect cells expressed mostly soluble active rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf5f84a6c0489c873e15f8e0ff78894
https://pubmed.ncbi.nlm.nih.gov/7626037
https://pubmed.ncbi.nlm.nih.gov/7626037
Publikováno v:
European journal of biochemistry. 146(3)
Liver supernatant from normal and alloxan-diabetic rats was fractionated by DEAE-cellulose chromatography and the separated phosphoprotein phosphatase fractions were assayed with [32P]histone f2b, [32P]phosphorylase a and [32P]phosphorylase kinase as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d732d7d93583dd33eef77a18833ecf11
https://pubmed.ncbi.nlm.nih.gov/2982604
https://pubmed.ncbi.nlm.nih.gov/2982604
Publikováno v:
European Journal of Biochemistry. 2/1/85, Vol. 146 Issue 3, p699-704. 6p.
Publikováno v:
Diabetes; May1995 Supplement 1, Vol. 44, p1A-1A, 333p