Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Carol J, Wikstrand"'
Autor:
Darell D. Bigner, Ira H. Pastan, Chien-Tsun Kuan, Roger E. McLendon, Carol J. Wikstrand, Hailan Piao, Scott E. Szafranski, Charles N. Pegram, Stephen T. Keir, Xuhui Bao, Vidyalakshmi Chandramohan
Supplementary Figure Legends - PDF file 88K, Supplementary Figure Legends 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57827a40d5e97fa0f84d6dc15d4368d
https://doi.org/10.1158/1078-0432.22447890.v1
https://doi.org/10.1158/1078-0432.22447890.v1
Autor:
Darell D. Bigner, Ira H. Pastan, Chien-Tsun Kuan, Roger E. McLendon, Carol J. Wikstrand, Hailan Piao, Scott E. Szafranski, Charles N. Pegram, Stephen T. Keir, Xuhui Bao, Vidyalakshmi Chandramohan
Supplementary Methods - PDF file 94K, The supplementary methods section describes the following: Construction, expression and purification of different EGFRvIII deletion mutants, cloning of variable heavy (VH) and variable light (VL) domains of P588
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9fc021499967905c42beb95c7bfd54
https://doi.org/10.1158/1078-0432.22447884.v1
https://doi.org/10.1158/1078-0432.22447884.v1
Autor:
Darell D. Bigner, Ira H. Pastan, Chien-Tsun Kuan, Roger E. McLendon, Carol J. Wikstrand, Hailan Piao, Scott E. Szafranski, Charles N. Pegram, Stephen T. Keir, Xuhui Bao, Vidyalakshmi Chandramohan
Supplementary Figures 1-9 - Supplementary Figures 1-9 - PDF file 516K, Supplementary Figure S1. Deduced amino acid sequence of the D2C7 scFv cloned from D2C7 hybridoma. VH (A) and VL (B) antigen-binding regions of the D2C7 scFv. Amino acid numbering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3c8becb44d363b42717644935e5b6d
https://doi.org/10.1158/1078-0432.22447887
https://doi.org/10.1158/1078-0432.22447887
Autor:
Darell D. Bigner, Ira H. Pastan, Chien-Tsun Kuan, Roger E. McLendon, Carol J. Wikstrand, Hailan Piao, Scott E. Szafranski, Charles N. Pegram, Stephen T. Keir, Xuhui Bao, Vidyalakshmi Chandramohan
Purpose: The EGF receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma. We tested the preclinical efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, which is react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f430ba6f517228132aa45ef5e49135
https://doi.org/10.1158/1078-0432.c.6521244.v1
https://doi.org/10.1158/1078-0432.c.6521244.v1
Autor:
Roger E. McLendon, Ujendra Kumar, Darell D. Bigner, Carol J. Wikstrand, Michael R. Zalutsky, Chien-Tsun Kuan
Publikováno v:
Hybridoma. 28:389-403
Somatostatin receptor 2 (SSTR2) is expressed by most medulloblastomas (MEDs). We isolated monoclonal antibodies (MAbs) to the 12-mer (33)QTEPYYDLTSNA(44), which resides in the extracellular domain of the SSTR2 amino terminus, screened the peptide-bou
Autor:
Jennifer R. Grandis, Francesca M. Coppelli, Sufi M. Thomas, John C. Sok, Darell D. Bigner, Miriam N. Lango, Carol J. Wikstrand, William E. Gooding, Sichuan Xi, Frank B. Furnari, Maria L. Freilino, Jennifer L. Hunt, Michael W. Graner
Publikováno v:
Clinical Cancer Research. 12:5064-5073
Purpose: Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinoma (HNSCC) where expression levels correlate with decreased survival. Therapies that block EGFR have shown limited efficacy in clinical trials and
Autor:
James E. Herndon, David A. Reardon, Darell D. Bigner, Gregory J. Riggins, Chien-Tsun Kuan, Michael W. Graner, Jeannette M. Dowell, Carol J. Wikstrand, Kenji Wakiya
Publikováno v:
Clinical Cancer Research. 12:1970-1982
Purpose: More brain tumor markers are required for prognosis and targeted therapy. We have identified and validated promising molecular therapeutic glioblastoma multiforme (GBM) targets: human transmembrane glycoprotein nonmetastatic melanoma protein
Autor:
Weilian Yang, Rolf F. Barth, Gong Wu, Michael J. Ciesielski, Robert A. Fenstermaker, Bradford A. Moffat, Brian D. Ross, Carol J. Wikstrand
Publikováno v:
Clinical Cancer Research. 11:341-350
Purpose: The goals of the present study were 2-fold: (a) to develop and characterize a rat brain tumor model that could be used for studies of molecular targeting of EGFRvIII and (b) to study the tumor localizing properties of radiolabeled monoclonal
Autor:
Ranjit K. Goudar, Qing Shi, Mark D. Hjelmeland, Stephen T. Keir, Roger E. McLendon, Carol J. Wikstrand, Elizabeth D. Reese, Charles A. Conrad, Peter Traxler, Heidi A. Lane, David A. Reardon, Webster K. Cavenee, Xiao-Fan Wang, Darell D. Bigner, Henry S. Friedman, Jeremy N. Rich
Publikováno v:
Molecular Cancer Therapeutics. 4:101-112
Malignant gliomas are highly lethal tumors that display striking genetic heterogeneity. Novel therapies that inhibit a single molecular target may slow tumor progression, but tumors are likely not dependent on a signal transduction pathway. Rather, m
Autor:
Guenter Bernhardt, Melinda K. Merrill, John H. Sampson, Darell D. Bigner, Matthias Gromeier, Carol J. Wikstrand
Publikováno v:
Neuro-Oncology. 6:208-217
Human pathogenic viruses are increasingly common vehicles for the development of novel therapeutic agents against malignant glioma (Gromeier, 2001; Gromeier and Wimmer, 2001; Gromeier et al., 2000a). The first reported incidences of viral oncolysis w