Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Carol J, Milligan"'
Autor:
Carol J. Milligan, Lyndsey L. Anderson, Michael T. Bowen, Samuel D. Banister, Iain S. McGregor, Jonathon C. Arnold, Steven Petrou
Publikováno v:
Journal of Cannabis Research, Vol 4, Iss 1, Pp 1-12 (2022)
Abstract Background Purified cannabidiol (CBD), a non-psychoactive phytocannabinoid, has gained regulatory approval to treat intractable childhood epilepsies. Despite this, artisanal and commercial CBD-dominant hemp-based products continue to be used
Externí odkaz:
https://doaj.org/article/58d1be1bbaa14277b5551605e16ab7e9
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy. Indeed, the phytocannabinoids cannabigerolic acid (CBGA
Externí odkaz:
https://doaj.org/article/36157173af714edb85cf3c7397637c4c
Autor:
Leanne Stokes, Rachel Glover, Michael D. Lovelace, Steven Petrou, Ben J. Gu, James S. Wiley, Carol J. Milligan, Kristen K. Skarratt, Stephen J. Fuller
Publikováno v:
The FASEB Journal. 34:3884-3901
P2X7 is an ATP-gated membrane ion channel that is expressed by multiple cell types. Brief exposure to ATP induces the opening of a nonselective cation channel; while repeated or prolonged exposure induces formation of a transmembrane pore. This proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159a5b63b01519f4d93eba121277cc5f
https://doi.org/10.1096/fj.201901198rr
https://doi.org/10.1096/fj.201901198rr
Autor:
Toshiyuki Yamamoto, Keiko Shimojima, Noriko Sangu, Yuta Komoike, Atsushi Ishii, Shinpei Abe, Shintaro Yamashita, Katsumi Imai, Tetsuo Kubota, Tatsuya Fukasawa, Tohru Okanishi, Hideo Enoki, Takuya Tanabe, Akira Saito, Toru Furukawa, Toshiaki Shimizu, Carol J Milligan, Steven Petrou, Sarah E Heron, Leanne M Dibbens, Shinichi Hirose, Akihisa Okumura
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118946 (2015)
Nucleotide alterations in the gene encoding proline-rich transmembrane protein 2 (PRRT2) have been identified in most patients with benign partial epilepsies in infancy (BPEI)/benign familial infantile epilepsy (BFIE). However, not all patients harbo
Externí odkaz:
https://doaj.org/article/f2bfadebdfbf47f1bde9c651428331f0
Autor:
Carol J. Milligan, Lyndsey L. Anderson, Michael T. Bowen, Samuel D. Banister, Iain S. McGregor, Jonathon C. Arnold, Steven Petrou
Publikováno v:
Journal of cannabis research. 4(1)
Background Purified cannabidiol (CBD), a non-psychoactive phytocannabinoid, has gained regulatory approval to treat intractable childhood epilepsies. Despite this, artisanal and commercial CBD-dominant hemp-based products continue to be used by epile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e829f2d54ef1921241e534eccc684be2
https://pubmed.ncbi.nlm.nih.gov/35689251
https://pubmed.ncbi.nlm.nih.gov/35689251
Autor:
Svenja Pachernegg, Carol J. Milligan
Publikováno v:
Patch Clamp Electrophysiology ISBN: 9781071608173
Genetic mutations have long been implicated in epilepsy, particularly in genes that encode ion channels and neurotransmitter receptors. Among some of those identified are voltage-gated sodium, potassium and calcium channels, and ligand-gated gamma-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7762866061a647b3f904086a08f7238e
https://doi.org/10.1007/978-1-0716-0818-0_7
https://doi.org/10.1007/978-1-0716-0818-0_7
Autor:
Carol J, Milligan, Svenja, Pachernegg
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2188
Genetic mutations have long been implicated in epilepsy, particularly in genes that encode ion channels and neurotransmitter receptors. Among some of those identified are voltage-gated sodium, potassium and calcium channels, and ligand-gated gamma-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::605459eb9d5faec4096397a97e00b19d
https://pubmed.ncbi.nlm.nih.gov/33119850
https://pubmed.ncbi.nlm.nih.gov/33119850
Autor:
Mehdi Mobli, Gyorgy Panyi, Volker Herzig, Christopher A. Reid, Laura H. Jacobson, Robert J. Richardson, Agota Csoti, Chun Yuen Chow, Glenn F. King, Kay L. Richards, Carol J. Milligan, Morten Grunnet, Steven Petrou, Eivind A. B. Undheim, Nikola Jancovski
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Spider venom is a rich source of peptides, many targeting ion channels. We assessed a venom peptide, Hm1a, as a potential targeted therapy for Dravet syndrome, the genetic epilepsy linked to a mutation in the gene encoding the sodium cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183a53b76d0197e4854a3d52dc167984
http://europepmc.org/articles/PMC6112713
http://europepmc.org/articles/PMC6112713
Autor:
Frederick Andermann, Zaid Afawi, Krystyna Spodar, Laura Licchetta, Francesca Bisulli, Rachel Straussberg, Laura Canafoglia, Snezana Maljevic, Bernt A. Engelsen, Silvana Franceschetti, Simone Mandelstam, Samuel F. Berkovic, Rikke S. Møller, Annette Wulf, Eva Andermann, João Massano, Francesca Ragona, Elena Gardella, Carlo Di Bonaventura, Steven Petrou, Patrizia Riguzzi, Guido Rubboli, Carol J. Milligan, Anna-Elina Lehesjoki, Karen Oliver, Ferruccio Panzica, Elena Pasini, Amos D. Korczyn, Mikko Muona, Roberto Michelucci, Daniel Friedman, Anna M. Boguszewska-Chachulska, Holger Lerche, Matthias Lindenau, Felix Benninger, Christopher A. Reid, Bruria Ben-Zeev, Paolo Tinuper, Arielle Crespel, Anetta Lasek-Bal
Publikováno v:
Oliver, K L, Franceschetti, S, Milligan, C J, Muona, M, Mandelstam, S A, Canafoglia, L, Boguszewska-Chachulska, A M, Korczyn, A D, Bisulli, F, Di Bonaventura, C, Ragona, F, Michelucci, R, Ben-Zeev, B, Straussberg, R, Panzica, F, Massano, J, Friedman, D, Crespel, A, Engelsen, B A, Andermann, F, Andermann, E, Spodar, K, Lasek-Bal, A, Riguzzi, P, Pasini, E, Tinuper, P, Licchetta, L, Gardella, E, Lindenau, M, Wulf, A, Møller, R S, Benninger, F, Afawi, Z, Rubboli, G, Reid, C A, Maljevic, S, Lerche, H, Lehesjoki, A-E, Petrou, S & Berkovic, S F 2017, ' Myoclonus epilepsy and ataxia due to KCNC1 mutation : Analysis of 20 cases and K(+) channel properties ', Annals of Neurology, vol. 81, no. 5, pp. 677-689 . https://doi.org/10.1002/ana.24929
OBJECTIVE: To comprehensively describe the new syndrome of myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK), including cellular electrophysiological characterization of observed clinical improvement with fever.METHODS: We analyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e24095de7d217867a83d748eead4731
https://doi.org/10.1002/ana.24929
https://doi.org/10.1002/ana.24929
Autor:
Maria G. Criscuoli, James S. Wiley, Mary Encarnacion, Xin Huang, Carles Vilariño-Güell, A. Dessa Sadovnick, Amber Ou, Cecily Q. Bernales, Irene M. Yee, Steven Petrou, Ben J. Gu, Carol J. Milligan, Anthony Traboulsee
Publikováno v:
Human Mutation. 38:736-744
Genetic variants in the purinergic receptors P2RX4 and P2RX7 have been shown to affect susceptibility to multiple sclerosis (MS). In this study, we set out to evaluate whether rare coding variants of major effect could also be identified in these pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2fb8923ccd28813f9b56953f0c626c
https://doi.org/10.1002/humu.23218
https://doi.org/10.1002/humu.23218