Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Carol Hui Hu"'
Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors
Autor:
Xiaohong Ying, Joelle M. Onorato, Heather Finlay, Nathalie Toussaint, Tammy C. Wang, Yi-Xin Li, David S. Taylor, Ruth R. Wexler, Alice Y.A. Chen, Carol Hui Hu, Jennifer X. Qiao, Lauren Haque, Christine Huang, Lynn M. Abell, Leonard P. Adam, David A. Gordon, Hong Shen, Michael Galella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3721-3725
Endothelial lipase (EL) inhibitors have been shown to elevate HDL-C levels in pre-clinical murine models and have potential benefit in prevention and treatment of cardiovascular diseases. Modification of the 1-ethyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-
Autor:
Javed Khan, Xiaoqin Liu, Sutjano Jusuf, Carol Hui Hu, Gregory A. Locke, Franck Duclos, Ruth R. Wexler, Gerald J. Duke, Joanne M. Smallheer, Ellen K. Kick, Meriah Neissel Valente, O. Scott Halpern
Publikováno v:
Bioorganicmedicinal chemistry letters. 42
Myeloperoxidase (MPO), a critical enzyme in antimicrobial host-defense, has been implicated in chronic inflammatory diseases such as coronary artery disease. The design and evaluation of MPO inhibitors for the treatment of cardiovascular disease are
Autor:
Mikhail Kagan, Carol Hui Hu, Thomas D. Harris, Megan Hayes, Padmaja Yalamanchili, Kelley Hanson, Ming Yu, Michael Azure, Ajay Purohit, Simon P. Robinson, Reinaldo Jones, Michael Cdebaca, Mary Guaraldi, Radeke Heike S, David S. Casebier
Publikováno v:
ACS Medicinal Chemistry Letters. 2:650-655
A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribu
Publikováno v:
Organic Letters. 13:1804-1807
The (hetero)aromatic trifluoromethyl group is present in many biologically active molecules and is generally considered to be chemically stable. In this paper, a convenient one-step synthesis of C-C linked aryl-heterocycles or heteroaryl-heterocycles
Publikováno v:
ChemInform. 42
A wide range of heterocyclic compounds is prepared in a one-pot one-step reaction without any organic solvent.