Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Carol Houghton"'
Publikováno v:
Developmental Dynamics. 233:1332-1336
Here, we exploit an absolute differential between stem and progeny cells in their ability to express Cre from a somatically inducible transgene to determine the longevity of intestinal Paneth cells. In the Ahcre transgenic line induction of Cre recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06eaf31f60b44c7c3edd9ff21fb64d09
https://doi.org/10.1002/dvdy.20446
https://doi.org/10.1002/dvdy.20446
Autor:
Bruce A.J. Ponder, Kenneth Jones, Lucinda F. Reynolds, Darrin P. Smith, Louise Howard, Douglas J. Winton, Carol Houghton, Aaron N. Cranston
Publikováno v:
Oncogene. 20:3986-3994
Gain-of-function mutations in the gene encoding the receptor tyrosine kinase RET have been identified as the aetiological factor for multiple endocrine neoplasia type 2A (MEN2A). MEN2A is a dominantly-inherited cancer predisposition syndrome characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab626086d378c8ad632c725ff4a12b77
https://doi.org/10.1038/sj.onc.1204434
https://doi.org/10.1038/sj.onc.1204434
Autor:
Carol Houghton, Catherine S. Healey, Andrea Frilling, Donna Neuberg, E. Dillwyn Williams, Charis Eng, Gerry A. Thomas, Friedhelm Raue, Bruce A.J. Ponder, Lois M. Mulligan
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:4310-4313
Mutations in the RET proto-oncogene, which encodes a receptor tyrosine kinase, are associated with the pathogenesis of medullary thyroid carcinoma (MTC). Somatic mutations in RET, predominantly at codon 918, and very rarely at codon 883, have been fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a30fca63dfe4d10dbd2d6069ead98cc
https://doi.org/10.1210/jcem.83.12.5345
https://doi.org/10.1210/jcem.83.12.5345
Publikováno v:
Oncogene. 15:1213-1217
Germline mutations in the RET proto-oncogene are seen in the majority of patients with the dominantly inherited cancer syndromes multiple endocrine neoplasia type 2 (MEN 2). The clinical subtypes of MEN 2 (MEN 2A, MEN 2B and familial MTC) all have me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5270ec43af22bfca1f2d23ffa8ddff6
https://doi.org/10.1038/sj.onc.1201481
https://doi.org/10.1038/sj.onc.1201481
Autor:
Timothy J. Stonehouse, Tony Pawson, Bruce Ponder, Gerald D. Gish, Darrin P. Smith, Carol Houghton, M. J. Lorenzo
Publikováno v:
Oncogene. 14:763-771
Activating germline mutations of the RET receptor tyrosine kinase are found in the majority of cases of inherited cancer syndrome MEN 2, and inactivating mutations in some cases of dominantly inherited Hirschsprung disease. Using RET activated by a M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1ef89daaa65a6efad3e2fd30d0a30f
https://doi.org/10.1038/sj.onc.1200894
https://doi.org/10.1038/sj.onc.1200894
Autor:
A Prowse, Patricia L. M. Dahia, Charis Eng, Catherine S. Healey, S L Chew, J L O'Riordan, P A Crossey, Sergio P. A. Toledo, Carol Houghton, Lois M. Mulligan
Publikováno v:
Journal of Medical Genetics. 32:934-937
Phaeochromocytomas may occur sporadically, or as part of the inherited cancer syndromes multiple endocrine neoplasia (MEN) type 2, von Hippel-Lindau disease (VHL), and, rarely, in type 1 neurofibromatosis. In MEN 2, germline missense mutations have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8236047ab7a8ff9d9033ac4d53170d9
https://doi.org/10.1136/jmg.32.12.934
https://doi.org/10.1136/jmg.32.12.934
Autor:
Susan C McCutcheon, Heather Ireland-Zecchini, Sarah A. Cumming, John Saunders, Richard Kemp, Louise Howard, Carol Houghton, Kenneth D Jones, Douglas J. Winton
Publikováno v:
BMC Biology
BMC Biology, Vol 8, Iss 1, p 89 (2010)
BMC Biology, Vol 8, Iss 1, p 89 (2010)
Background Reporter genes are widely used in biology and only a limited number are available. We present a new reporter gene for the localization of mammalian cells and transgenic tissues based on detection of the bglA (SYNbglA) gene of Caldocellum s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4064c1495110b6841ed3d83caa3b2525
https://doi.org/10.1186/1741-7007-8-89
https://doi.org/10.1186/1741-7007-8-89
Autor:
Charis Eng, Lois M. Mulligan, Catherine S. Healey, Keith Foster, Carol Houghton, Simon A. Gayther, Bruce A.J. Ponder
Publikováno v:
Scopus-Elsevier
British Journal of Cancer
British Journal of Cancer
The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic MTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c396a55f08a89b66556069f833b12d0
https://doi.org/10.1038/bjc.1996.363
https://doi.org/10.1038/bjc.1996.363
Autor:
Carol Houghton, Louise Howard, Douglas J. Winton, Heather Ireland, Alan Richard Clarke, Owen J. Sansom, Richard Kemp
Publikováno v:
Gastroenterology. 126(5)
Background & Aims: A system for introducing specific gene mutations into the epithelia of the adult murine gastrointestinal tract by the transcriptional regulation of Cre recombinase is presented and applied to delete β-catenin, a central mediator o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a7ab6f43cc64cb853c864a385999da
https://pubmed.ncbi.nlm.nih.gov/15131783
https://pubmed.ncbi.nlm.nih.gov/15131783
Autor:
Douglas J. Winton, Louise Howard, Carol Houghton, Richard Kemp, Heather Ireland, Elizabeth Clayton
Somatically inducible Cre lines are used extensively to study gene function. However, a background level of spontaneous recombination due to unregulated expression of Cre is particularly confounding for cancer models in which following the pathogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c4fcadfa78099dd4f61ceb55a9ab5d
https://europepmc.org/articles/PMC443557/
https://europepmc.org/articles/PMC443557/
