A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers.

Autor: Kun Yu, Kumaresan Ganesan, Lay Keng Tan, Mirtha Laban, Jeanie Wu, Xiao Dong Zhao, Hongmin Li, Carol Ho Wing Leung, Yansong Zhu, Chia Lin Wei, Shing Chuan Hooi, Lance Miller, Patrick Tan

Publikováno v: PLoS Genetics, Vol 4, Iss 7, p e1000129 (2008)

Successful tumor development and progression involves the complex interplay of both pro- and anti-oncogenic signaling pathways. Genetic components balancing these opposing activities are likely to require tight regulation, because even subtle alterat

Externí odkaz: https://doaj.org/article/b616a2162972477597178fd5b4f9eef8

HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population

Autor: Shing Chuan Hooi, Celestial T. Yap, Philip Iau, Carol Ho-Wing Leung, Ser Yeng Ler, Guo-Dong Lu, Mikael Hartman, Lay Wai Khin, Manuel Salto-Tellez

Publikováno v: Ler, S Y, Leung, C H W, Khin, L W, Lu, G-D, Salto-Tellez, M, Hartman, M, Iau, P T C, Yap, C T & Hooi, S C 2015, ' HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population ', Oncology Reports, vol. 34, no. 5, pp. 2238-2250 . https://doi.org/10.3892/or.2015.4263
Oncology Reports

Histone deacetylases (HDACs) are enzymes involved in transcriptional repression. We aimed to examine the significance of HDAC1 and HDAC2 gene expression in the prediction of recurrence and survival in 156 patients with hepatocellular carcinoma (HCC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb47c66117522cc9cf3a38cb0b93831
https://pure.qub.ac.uk/en/publications/e78d9eb9-6b7d-448b-b979-f25de3619e02

Trans-neuronal regulation of cortical apoptosis in the adult rat olfactory system

Autor: Donald A. Wilson, Carol Ho-Wing Leung

Publikováno v: Brain Research. 984:182-188

Previous work has identified a population of neurons within the anterior piriform cortex that undergo rapid apoptosis following de-afferentation by olfactory bulbectomy in adult rats. The specific initiation signal for apoptosis in this paradigm is u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ca8c5e50453bcfc93f3f686381e2fc
https://doi.org/10.1016/s0006-8993(03)03129-9

The use of point-of-decision prompts to increase stair climbing in Singapore

Autor: Robert A. Sloan, Falk Müller-Riemenschneider, Carol Ho-Wing Leung, Benjamin Haaland

Publikováno v: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 10, Iss 1, Pp 210-218 (2013)
International Journal of Environmental Research and Public Health; Volume 10; Issue 1; Pages: 210-218

Physical inactivity is a significant contributor to worldwide mortality and morbidity associated with non-communicable diseases. An excellent avenue to incorporate lifestyle physical activity into regular routine is to encourage the use of stairs dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806bcdef657baec380e5e722b91409ad
https://pubmed.ncbi.nlm.nih.gov/23296208

PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage

Autor: Guo-Dong Lu, Carol Ho-Wing Leung, Shing Chuan Hooi, Jianjun Liu, Jingli Zhuo, Baohua Huang, Celestial T. Yap

Publikováno v: Cell Death & Disease

p53 has a crucial role in governing cellular mechanisms in response to a broad range of genotoxic stresses. During DNA damage, p53 can either promote cell survival by activating senescence or cell-cycle arrest and DNA repair to maintain genomic integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092ec4c5329aa55f7b1b02b6e411025e
https://doi.org/10.1038/cddis.2012.180