Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Carol Herkimer"'
Autor:
Rodolfo C. Cardoso, Carol Herkimer, Almudena Veiga-Lopez, Vasantha Padmanabhan, Muraly Puttabyatappa
Publikováno v:
Reproduction. 152:139-150
Gestational testosterone (TS) excess, acting via both the androgenic and estrogenic pathways, advances puberty and disrupts the neuroendocrine estradiol (E2) feedback and periovulatory hormonal dynamics in female sheep. These prenatally programmed de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf9999ccbba5681db1461e52b43b7b5
https://doi.org/10.1530/rep-16-0065
https://doi.org/10.1530/rep-16-0065
Publikováno v:
Toxicology and Applied Pharmacology. 268:300-308
Bisphenol-A (BPA), a polymer used in plastics manufacturing, and methoxychlor (MXC), a pesticide, are endocrine disrupting compounds with estrogenic and anti-androgenic properties. Prenatal BPA or MXC treatment induces reproductive defects in sheep w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bb0c77f6c1dfd2a7ed5d98082435a7
https://doi.org/10.1016/j.taap.2013.02.011
https://doi.org/10.1016/j.taap.2013.02.011
Publikováno v:
Endocrinology. 153:2813-2822
Prenatal testosterone (T) excess compromises the estradiol (E2) positive feedback. This study tested the hypothesis that antagonizing androgen action or improving insulin sensitivity prenatally would prevent positive feedback disruptions from develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0125c910fc996e527e045247800cbd
https://doi.org/10.1210/en.2011-2074
https://doi.org/10.1210/en.2011-2074
Publikováno v:
Endocrinology. 150:1456-1465
Sheep exposed to testosterone (T) during early to midgestation exhibit reproductive defects that include hypergonadotropism, functional hyperandrogenism, polycystic ovaries, and anovulatory infertility, perturbations similar to those observed in wome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776d2977f23521368115f1bae826e7de
https://doi.org/10.1210/en.2008-1256
https://doi.org/10.1210/en.2008-1256
Autor:
Fred J. Karsch, Robert C. Thompson, Jonathan N. Flak, Carol Herkimer, Vasantha Padmanabhan, Kathleen B. Welch, Mohan Manikkam
Publikováno v:
Biology of Reproduction. 78:648-660
The goal of this study was to explore mechanisms that mediate hypersecretion of LH and progressive loss of cyclicity in female sheep exposed during fetal life to excess testosterone. Our working hypothesis was that prenatal testosterone excess, by it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de55c05f6067714aba5e1b212c7232cd
https://doi.org/10.1095/biolreprod.107.063347
https://doi.org/10.1095/biolreprod.107.063347
Autor:
Carol Herkimer, Wen Ye, Vasantha Padmanabhan, David James Phillips, Philip G. Knight, Almudena Veiga-Lopez
Publikováno v:
Biology of Reproduction. 78:636-647
Prenatal testosterone excess leads to neuroendocrine, ovarian, and metabolic disruptions, culminating in reproductive phenotypes mimicking that of women with polycystic ovary syndrome (PCOS). The objective of this study was to determine the consequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea48e18f7c3c5c908a0195067f8ee86a
https://doi.org/10.1095/biolreprod.107.065904
https://doi.org/10.1095/biolreprod.107.065904
Autor:
Jacob Moeller, Vasantha Padmanabhan, Carol Herkimer, Bachir Abi Salloum, Evan M. Beckett, Rohit Sreedharan, Almudena Veiga-Lopez
Publikováno v:
Endocrinology. 156(7)
Prenatal T excess induces maternal hyperinsulinemia, early puberty, and reproductive/metabolic defects in the female similar to those seen in women with polycystic ovary syndrome. This study addressed the organizational/activational role of androgens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2487939dab0ea02471c9d8b6e2633fad
https://pubmed.ncbi.nlm.nih.gov/25919188
https://pubmed.ncbi.nlm.nih.gov/25919188
Autor:
Kathleen B. Welch, Hirendra N. Sarma, Vasantha Padmanabhan, James M. Dell’Orco, Carol Herkimer, Mohan Manikkam, Douglas L. Foster
Publikováno v:
Endocrinology. 146:4281-4291
Exposure of female sheep fetuses to excess testosterone (T) during early to midgestation produces postnatal hypergonadotropism manifest as a selective increase in LH. This hypergonadotropism may result from reduced sensitivity to estradiol (E2) negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fca9d3ae5c547b010a127a9e57c0c3
https://doi.org/10.1210/en.2005-0322
https://doi.org/10.1210/en.2005-0322
Autor:
Vasantha Padmanabhan, Douglas L. Foster, James S. Lee, Carol Herkimer, Tejinder Pal Sharma, Mozhgan Savabieasfahani
Publikováno v:
Biology of Reproduction. 72:221-229
Prenatal exposure of the female sheep to excess testosterone (T) leads to hypergonadotropism, multifollicular ovaries, and progressive loss of reproductive cycles. We have determined that prenatal T treatment delays the latency of the estradiol (E2)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03802a69e41669e94d3c310e36a62d05
https://doi.org/10.1095/biolreprod.104.031070
https://doi.org/10.1095/biolreprod.104.031070
Autor:
Rachel A. Birch, Wen Ye, Carol Herkimer, Christine West, Jane E. Robinson, Tejinder Pal Sharma, Vasantha Padmanabhan, Douglas L. Foster
Publikováno v:
Biology of Reproduction. 66:924-933
We studied the impact of prenatal androgen exposure on the timing of onset of puberty, maintenance of cyclicity in the first breeding season, and the LH surge mechanism in female sheep. Pregnant sheep were injected with testosterone propionate (100 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8abffdf41251737cc4b9e29779a2b34c
https://doi.org/10.1095/biolreprod66.4.924
https://doi.org/10.1095/biolreprod66.4.924