Výsledky vyhledávání - "Carol H. Sampson"

Prostaglandin E2 Enhances Aged Hematopoietic Stem Cell Function

Autor: P. Artur Plett, Yunlong Liu, Christie M. Orschell, Louis M. Pelus, Carol H. Sampson, Edward Simpson, Andrea M. Patterson

Publikováno v: Stem Cell Reviews and Reports. 17:1840-1854

Aging of hematopoiesis is associated with increased frequency and clonality of hematopoietic stem cells (HSCs), along with functional compromise and myeloid bias, with donor age being a significant variable in survival after HSC transplantation. No c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88ed6118e46297291289274c2846696e
https://doi.org/10.1007/s12015-021-10177-z

Zobrazit plný text záznamu

Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome

Autor: Andrea M. Patterson, Sasidhar Vemula, P. Artur Plett, Carol H. Sampson, Hui Lin Chua, Alexa Fisher, Tong Wu, Rajendran Sellamuthu, Hailin Feng, Barry P. Katz, Colleen M. DesRosiers, Louis M. Pelus, George N. Cox, Thomas J. MacVittie, Christie M. Orschell

Publikováno v: Radiation research. 198(3)

The hematopoietic system is highly sensitive to stress from both aging and radiation exposure, and the hematopoietic acute radiation syndrome (H-ARS) should be modeled in the geriatric context separately from young for development of age-appropriate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38749e9efe544ae447e452093c83fd24
https://pubmed.ncbi.nlm.nih.gov/35834823

Zobrazit plný text záznamu

Upregulation of SIRT1 Contributes to dmPGE2-dependent Radioprotection of Hematopoietic Stem Cells

Autor: Liqiong, Liu, Hongge, Li, Andrea M, Patterson, P Artur, Plett, Carol H, Sampson, Khalid S, Mohammad, Maegan L, Capitano, Pratibha, Singh, Chonghua, Yao, Christie M, Orschell, Louis M, Pelus

Publikováno v: Stem cell reviews and reports. 18(4)

Exposure to potentially lethal high-dose ionizing radiation results in bone marrow suppression, known as the hematopoietic acute radiation syndrome (H-ARS), which can lead to pancytopenia and possible death from hemorrhage or infection. Medical count

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbccf0d6595bb160f66c56c9622596fb
https://pubmed.ncbi.nlm.nih.gov/35318613

Zobrazit plný text záznamu

Development of a Model of the Acute and Delayed Effects of High Dose Radiation Exposure in Jackson Diversity Outbred Mice; Comparison to Inbred C57BL/6 Mice

Autor: Hailin Feng, Steven J. Miller, P. Artur Plett, Hui Lin Chua, Thomas J. MacVittie, Alexa Fisher, Christie M. Orschell, Barry P. Katz, Andrea M. Patterson, Carol H. Sampson, Joseph L. Unthank

Publikováno v: Health Phys

Development of medical countermeasures against radiation relies on robust animal models for efficacy testing. Mouse models have advantages over larger species due to economics, ease of conducting aging studies, existence of historical databases, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dfb4fc33ae53c6ae452b7f7145822c
https://doi.org/10.1097/hp.0000000000001344

Zobrazit plný text záznamu

A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells

Autor: Jonathan Hoggatt, Khalid S. Mohammad, Andrea M. Patterson, Carol H. Sampson, Liqiong Liu, Maegan L. Capitano, Hongge Li, P. Artur Plett, Pratibha Singh, Christie M. Orschell, Louis M. Pelus

Publikováno v: Stem Cell Reports. 15:358-373

Summary Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E2 (dmPGE2) prior to lethal ionizing radiation (IR) facilitates survival, but the cellular and molecular mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5178d95e688dda70c326957e9006f59
https://doi.org/10.1016/j.stemcr.2020.07.004

Zobrazit plný text záznamu

Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass

Autor: Evan R. Himes, Kevin A. Maupin, Joydeep Ghosh, Louis M. Pelus, Christie M. Orschell, Paul Childress, Alexa Fisher, Marta B. Alvarez, Jung Min Hong, Irushi Abeysekera, Edward F. Srour, Pratibha Singh, Artur P. Plett, Safa F. Mohamad, Carol H. Sampson, Melissa A. Kacena, Angela Bruzzaniti, Hui Lin Chua

Publikováno v: Bone

Osteoblast number and activity decreases with aging, contributing to the age-associated decline of bone mass, but the mechanisms underlying changes in osteoblast activity are not well understood. Here, we show that the age-associated bone loss critic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed75ee58449e23bdae08dea993e4a6de
https://doi.org/10.1016/j.bone.2019.07.010

Zobrazit plný text záznamu