Výsledky vyhledávání

Adenovirus E1A Activation Domain Regulates H3 Acetylation Affecting Varied Steps in Transcription at Different Viral Promoters

Autor: Mario A. Pennella, Emily Hsu, Nathan R. Zemke, Arnold J. Berk, Carol Eng

Publikováno v: Journal of virology, vol 92, iss 18

How histone acetylation promotes transcription is not clearly understood. Here, we confirm an interaction between p300 and the adenovirus 2 large E1A activation domain (AD) and map the interacting regions in E1A by observing colocalization at an inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dffc20edb5efbda50fd00276396f54b
https://escholarship.org/uc/item/2js2d5dd

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Akademický článek

The Effects of Social Capital and Knowledge on Small US Firm New Product Development Innovations

Autor: Nancy Miller, Carol Engel-Enright, David Brown

Publikováno v: Journal of Innovation Management, Vol 10, Iss 3, Pp 1-25 (2022)

Studies have highlighted the benefits of external knowledge building as a means of heightening a firm’s innovation activities. Simultaneously supply chain scholars have highlighted the lack of focus on social facets at the micro behavioral level, a

Externí odkaz: https://doaj.org/article/345e909c441549d0b0db9080b5e21ed0

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Effect of PI3K/Akt pathway inhibition-mediated G1 arrest on chemosensitization in ovarian cancer cells

Autor: Mirela, Fekete, Chintda, Santiskulvong, Carol, Eng, Oliver, Dorigo

Publikováno v: Anticancer research. 32(2)

Pharmacological inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway prevents G(1) cell cycle progression into S, resulting in G(1) accumulation. The hypothesis that this arrest might negatively impact on chemotherapeutic agents primarily e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38445909fd635ed416a92338428a556f
https://pubmed.ncbi.nlm.nih.gov/22287731

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Dual Targeting of Phosphoinositide 3-Kinase and Mammalian Target of Rapamycin Using NVP-BEZ235 as a Novel Therapeutic Approach in Human Ovarian Carcinoma

Autor: Chintda Santiskulvong, Oliver Dorigo, Gottfried E. Konecny, Kuang-Yui Michael Chen, Amer Karam, Hong Wu, Mirela Fekete, Carol Eng, David J. Mulholland, Min Song

Purpose: This study evaluates the effect of dual PI3K and mTOR inhibition using NVP-BEZ235 in preclinical models of ovarian cancer as a potential novel therapeutic strategy. Experimental Design: Inhibition of PI3K/Akt/mTOR signaling by NVP-BEZ235 was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4aa79481f0e630bad20d9044c08651
https://europepmc.org/articles/PMC3078990/

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Cisplatin and PI3kinase inhibition decrease invasion and migration of human ovarian carcinoma cells and regulate matrix-metalloproteinase expression

Autor: Sara Zabih, Amer Karam, Oliver Dorigo, Mirela Fekete, Carol Eng, Chintda Santiskulvong

Publikováno v: Cytoskeleton.

Targeting of the PI3K (phosphoinositide3-kinase)/Akt/mTOR pathway in human ovarian cancer cells is a promising novel therapeutic strategy. We investigated the effects of cisplatin and the PI3K inhibitor LY294002 on invasion, migration and the express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd850028d8017c5aaeff174d5b63f192
https://doi.org/10.1002/cm.20465

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Akademický článek

Direct and moderation effects on U.S. apparel manufacturers’ engagement in network ties

Autor: Nancy J. Miller, Carol Engel-Enright, David A. Brown

Publikováno v: Journal of Entrepreneurship, Management and Innovation, Vol 17, Iss 3, Pp 67-113 (2021)

PURPOSE: Firms do not continue and prosper purely on their own individual endeavors, as each firm is influenced by the activities of others, and thus direct and indirect relationships shape the firm’s strategic management. These relationships form

Externí odkaz: https://doaj.org/article/2a361f7fd8d446878ca824334aa0341f

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Abstract 836: Insulin-like growth factor-I receptor (IGF-IR) dowregulation in cisplatin-resistant human ovarian cancer cells

Autor: Oliver Dorigo, Wing Yi Lung, Carol Eng, David T. Wang, Richard C. Koya, Chintda Santiskulvong, Sara Zabih

Publikováno v: Cancer Research. 72:836-836

Introduction: Ovarian cancer is the most lethal of the gynecological malignancies and the 5th leading cause of cancer related deaths amongst women in the US. It is a chemotherapy-sensitive disease, and about 85% of patients respond to first line trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d90e6cec77d0f0136c7b6322bdaef2e3
https://doi.org/10.1158/1538-7445.am2012-836

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Complete transformation by adenovirus 2 requires both E1A proteins

Autor: Arnold J. Berk, Carol Eng, Genevieve Courtois, Craig Montell

Publikováno v: Cell. 36(4)

Rodent cells transformed by adenovirus 2 (Ad2) express two highly related viral proteins of 289 and 243 amino acids encoded in early region 1A (E1A). Transformation studies were performed with adenovirus mutants that express only one or the other E1A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ad87ccab82b464715c8dc874fd3e58
https://pubmed.ncbi.nlm.nih.gov/6705049

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