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pro vyhledávání: '"Carol Elaine O'hear"'
Autor:
Carol Elaine O'hear, Jefferson Foote
Publikováno v:
Journal of molecular biology. 364(5)
The efficacy of chemotherapy on brain tumors is often hindered by the presence of the blood brain barrier. This barrier keeps many systemically administered substances from entering the cerebrospinal fluid (CSF), while allowing intrathecally administ
Autor:
Jefferson Foote, Carol Elaine O'hear
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(1)
Clearance is the practical limit on drug action. Here we propose a means of slowing clearance, thereby extending drug lifetimein vivoby “antibody buffering.” In this process, a drug and an anti-drug antibody are coadministered. Most of the drug i