Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Carol E. Jolly"'
Autor:
Amy Louise Ball, Carol E Jolly, Mark G Lennon, Jonathan J Lyon, Ana Alfirevic, Amy E Chadwick
Publikováno v:
eLife, Vol 12 (2023)
Background: Evidence supports an important link between mitochondrial DNA (mtDNA) variation and adverse drug reactions such as idiosyncratic drug-induced liver injury (iDILI). Here, we describe the generation of HepG2-derived transmitochondrial cybri
Externí odkaz:
https://doaj.org/article/cac0c9cc70c841ffb77c6bdfa52724f5
Autor:
Munir Pirmohamed, Sophie Grice, Dean J. Naisbitt, Anna Olsson-Brown, José L. Castrejón-Flores, Xiaoli Meng, Catherine J. Betts, Carol E. Jolly, Benjamin Alexis Fisher, Joshua Gardner, Neil Steven, Sean Hammond, Andrew Gibson
Publikováno v:
TOXICOLOGICAL SCIENCES
An emerging clinical issue associated with immune-oncology agents is the collateral effects on the tolerability of concomitant medications. One report of this phenomenon was the increased incidence of hypersensitivity reactions observed in patients r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f3410c63cfdf9092478c988a125491
https://pubmed.ncbi.nlm.nih.gov/34850240
https://pubmed.ncbi.nlm.nih.gov/34850240
Autor:
Joshua Gardner, Paul Thomson, Serat-E Ali, Dean J. Naisbitt, Munir Pirmohamed, Lorenzo Ressel, Sean Hammond, Carol E. Jolly, Anna Olsson-Brown, Daniel F. Carr
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Many adverse reactions associated with immune checkpoint inhibitor (ICI) treatments are immunologically driven and may necessitate discontinuation of the ICI. Herein, we present a patient who had been administered the radio contrast media amidotrizoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdf803eb683d8f7de46a0bb7f66a6ae
http://europepmc.org/articles/PMC8166637
http://europepmc.org/articles/PMC8166637
Autor:
Amy E. Chadwick, Oisin Douglas, Dominic P. Williams, B. Kevin Park, Damir Simic, Carol E. Jolly, Laleh Kamalian, Mario Monshouwer, Jan Snoeys
Publikováno v:
Current protocols in toxicology
Using galactose instead of glucose in the culture medium of hepatoma cell lines, such as HepG2 cells, has been utilized for a decade to unmask the mitochondrial liability of chemical compounds. A modified glucose-galactose assay on HepG2 cells, reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f063e1eeaf43c7963149955df9892dd4
https://doi.org/10.1002/cptx.76
https://doi.org/10.1002/cptx.76
Autor:
Jan Snoeys, Laleh Kamalian, B. Kevin Park, Dominic P. Williams, Amy E. Chadwick, Carol E. Jolly, Damir Simic, Mario Monshouwer, Oisin Douglas
Publikováno v:
TOXICOLOGY IN VITRO
The importance of mitochondrial toxicity in drug-induced liver injury is well established. The bioenergetic phenotype of the HepaRG cell line was defined in order to assess their suitability as a model of mitochondrial hepatotoxicity. Bioenergetic ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c30df695ad74462d47bc4f79e7ec50
http://livrepository.liverpool.ac.uk/3025983/1/Resubmission_HepaRG_Final.docx
http://livrepository.liverpool.ac.uk/3025983/1/Resubmission_HepaRG_Final.docx
Autor:
Carol E. Jolly, Rosalind E. Jenkins, B. Kevin Park, Alison J. Beckett, Jan Snoeys, Amy E. Chadwick, Sophie L. Penman, Oisin Douglas, Laleh Kamalian, Mario Monshouwer, Dominic P. Williams, Damir Simic
Publikováno v:
Toxicology and Applied Pharmacology
During its clinical development fialuridine caused liver toxicity and the death of five patients. This case remains relevant due to the continued development of mechanistically-related compounds against a back-drop of simple in vitro models which rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc33f6f2025f2dc67b6c695ac4dfd787
https://doi.org/10.1016/j.taap.2020.115163
https://doi.org/10.1016/j.taap.2020.115163
Publikováno v:
Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b170f154104164704c6dfa79b3b74623
https://doi.org/10.1002/9781119329725.ch6
https://doi.org/10.1002/9781119329725.ch6
Autor:
Lindsey J. Gray, C. Simon Herrington, Sonia Lain, Predrag Bjelogrlic, Carol E. Jolly, Virginia Appleyard, Alastair M. Thompson
Publikováno v:
International Journal of Cancer. 120:2317-2324
Human papillomavirus (HPV) infection is strongly associated with the development of anogenital neoplasia, particularly cervical cancer. It has been estimated that 99.7% of all cervical carcinomas are attributable to infection with HPV, and types 16 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67faff11ff250dc5a4c4ace8d2433334
https://doi.org/10.1002/ijc.22591
https://doi.org/10.1002/ijc.22591
Publikováno v:
International Journal of Oncology. 35
Cervical cancer is a major cause of death in women worldwide and is strongly associated with human papillomavirus (HPV) infection. Integration of HPV is thought to be a key step in malignant progression, and is associated with loss of regulation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36137c8ba7141ce2650f3488ba85e707
https://doi.org/10.3892/ijo_00000377
https://doi.org/10.3892/ijo_00000377