Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Carol E. Griffin"'
Autor:
Jonathan M. Hoke, Upeka Samarakoon, Junhui Duan, Roland A. Cooper, Jianbing Mu, David C. Warhurst, Michael T. Ferdig, Carol E. Griffin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:5356-5364
The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (−)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (−)-isomers in vitro and in vivo against Plasmodium falciparum malaria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfa95259c69610078a96bffc35ef9bd
https://doi.org/10.1128/aac.05667-11
https://doi.org/10.1128/aac.05667-11
Autor:
Carol E. Griffin, Gary H. Posner, Andrew S. Rosenthal, Roland A. Cooper, Carmony L. Hartwig, John G. D'angelo
Publikováno v:
Biochemical Pharmacology. 77:322-336
The antimalarial trioxanes, exemplified by the naturally occurring sesquiterpene lactone artemisinin and its semi-synthetic derivatives, contain an endoperoxide pharmacophore that lends tremendous potency against Plasmodium parasites. Despite decades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f8a5d0dae2ee793885426135278eeb
https://doi.org/10.1016/j.bcp.2008.10.015
https://doi.org/10.1016/j.bcp.2008.10.015