Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Carol Deminie"'
Autor:
Zhufang Li, Yongnian Sun, George J. Hanna, Ira B. Dicker, Max Lataillade, Carol Deminie, Tricia Protack, William Olds, Brian Terry, Mark Krystal, Beata Nowicka-Sans, Carey Hwang, Beatrice Minassian
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:5500-5508
BMS-986001 is a novel HIV nucleoside reverse transcriptase inhibitor (NRTI). To date, little is known about its resistance profile. In order to examine the cross-resistance profile of BMS-986001 to NRTI mutations, a replicating virus system was used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10536914bf58c89e13965a58d97b0840
https://doi.org/10.1128/aac.01195-13
https://doi.org/10.1128/aac.01195-13
Publikováno v:
Antiviral Chemistry and Chemotherapy. 23:77-91
In the search for new anti-influenza agents, the viral polymerase has often been targeted due to the involvement of multiple conserved proteins and their distinct activities. Polymerase associates with each of the eight singled-stranded negative-sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f497cff1dd87d4011205af30115525
https://doi.org/10.3851/imp2235
https://doi.org/10.3851/imp2235
Autor:
Carol Deminie, Timothy Johnson, Oak K. Kim, Andrew J. Staab, Zeyu Lin, Roger Remillard, Brian Terry, Nicholas A. Meanwell, Mark Krystal, Michael A. Walker, Albert Torri, Jacques Banville, Henry Wong, Himadri Samanta, Zhuping Ma, Yunhui Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2920-2924
Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. This study reports on the discovery of a new triketoacid-based chemotype that selectively inhibits the strand transfer reaction of HIV-integrase. SAR st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fd8b9d5313f5ff66df45302eb2a17b
https://doi.org/10.1016/j.bmcl.2006.03.010
https://doi.org/10.1016/j.bmcl.2006.03.010
Autor:
Nicholas A. Meanwell, Pin-Fang Lin, Carol Deminie, Tao Wang, Ronald E. Rose, Gregory Yamanaka, Yi-Fei Gong, H.-G. Heidi Wang, Zheng Yang, Robert A. Fridell, Nannan Zhou, Chang-Ben Li, Qi Guo, Lisa Zadjura, Gwendeline Demers, Richard J. Colonno, Brett S. Robinson, Timothy P. Spicer, Wade S. Blair
Publikováno v:
Proceedings of the National Academy of Sciences. 100:11013-11018
BMS-378806 is a recently discovered small molecule HIV-1 inhibitor that blocks viral entrance to cells. The compound exhibits potent inhibitory activity against a panel of R5-(virus using the CCR5 coreceptor), X4-(virus using the CXCR4 coreceptor), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc468007a6f932fc575ed309ebe43d4b
https://doi.org/10.1073/pnas.1832214100
https://doi.org/10.1073/pnas.1832214100
Autor:
Pin-Fang Lin, Qi Guo, Carol Deminie, Brian Terry, Fred Djang, Brett S. Robinson, Richard J. Colonno, Yi-Fei Gong, David A. Stock, Keith Riccardi, Wade S. Blair
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:2093-2099
BMS-232632 is an azapeptide human immunodeficiency virus type 1 (HIV-1) protease (Prt) inhibitor that exhibits potent anti-HIV activity with a 50% effective concentration (EC50) of 2.6 to 5.3 nM and an EC90of 9 to 15 nM in cell culture. Proof-of-prin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d485ca7baa3f54248ef28b1ca6e5f0ab
https://doi.org/10.1128/aac.44.8.2093-2099.2000
https://doi.org/10.1128/aac.44.8.2093-2099.2000
Autor:
Bechtold Clifford M, A K Patick, Himadri Samanta, R J White, Richard J. Colonno, Ronald E. Rose, P.-F. Lin, Keith Riccardi, M. Alam, Carol Deminie
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:133-138
The human immunodeficiency virus (HIV) fusion inhibitor siamycin I, a 21-residue tricyclic peptide, was identified from a Streptomyces culture by using a cell fusion assay involving cocultivation of HeLa-CD4+ cells and monkey kidney (BSC-1) cells exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be1f304d6ee46a6ac18433574a70fe5
https://doi.org/10.1128/aac.40.1.133
https://doi.org/10.1128/aac.40.1.133
Autor:
Nicholas A. Meanwell, Roger Remillard, Brian Terry, Timothy Norman Johnson, Albert Torri, Zeyu Lin, Serge Plamondon, Annapurna Pendri, Mark Krystal, Himadri Samanta, Michael A. Walker, Zhuping Ma, Yunhui Zhang, Jacques Banville, Daniel Smith, Carol Deminie, Henry Wong
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(22)
Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. A previous study of the diketoacid-based chemotype suggested that there are two aryl-binding domains on integrase. In this study, modifications to the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9185600969f1716a04d6ddbb5d2d2a98
https://pubmed.ncbi.nlm.nih.gov/16971121
https://pubmed.ncbi.nlm.nih.gov/16971121
Autor:
Lisa Zadjura, Owen Brendan Wallace, Keith Ricarrdi, Ronald E. Rose, Yi Fei Gong, Zheng Yang, Sunanda A. Ranadive, Tao Wang, Carol Deminie, Donald L. Tweedie, Fang Zhao, Stella Huang, Hwei Gene Heidi Wang, Pin fang Lin, Zhongxing Zhang, Haiquan Fang, Richard J. Colonno, Timothy P. Spicer, Nicholas A. Meanwell, Brett S. Robinson, Milind Deshpande, Pei Yong Shi, Wade S. Blair
Publikováno v:
Journal of medicinal chemistry. 46(20)
Indole derivative 1 interferes with the interaction of the HIV surface protein gp120 with the host cell receptor CD4. The 4-fluoro derivative 2 exhibited markedly enhanced potency and was bioavailable in the rat, dog, and cynomolgus monkey when admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f777ae4702da06fa315568ec6f66a6
https://pubmed.ncbi.nlm.nih.gov/13678401
https://pubmed.ncbi.nlm.nih.gov/13678401
In vitro resistance profile of the human immunodeficiency virus type 1 protease inhibitor BMS-232632
Autor:
Ronald E. Rose, David A. Stock, Timothy P. Spicer, Richard J. Colonno, Brett S. Robinson, Pin-Fang Lin, Carol Deminie, Yi-Fei Gong
Publikováno v:
Antimicrobial agents and chemotherapy. 44(9)
BMS-232632 is an azapeptide human immunodeficiency virus (HIV) type 1 (HIV-1) protease inhibitor that displays potent anti-HIV-1 activity (50% effective concentration [EC 50 ], 2.6 to 5.3 nM; EC 90 , 9 to 15 nM). In vitro passage of HIV-1 RF in the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acc44f8d6cbd7e9b2f842b1743ba1ad
https://pubmed.ncbi.nlm.nih.gov/10952574
https://pubmed.ncbi.nlm.nih.gov/10952574
Autor:
Pin-Fang Lin, T C Chou, Carol Deminie, Alfred H. Balch, F Djang, Bechtold Clifford M, M Prichard, M. Alam, Richard J. Colonno, David A. Stock
Publikováno v:
Antimicrobial agents and chemotherapy. 40(6)
Current treatments for human immunodeficiency virus (HIV) include both reverse transcriptase and protease inhibitors. Results from in vitro and clinical studies suggest that combination therapy can be more effective than single drugs in reducing vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39ffc6bc76aedfa233af4fe40e22999
https://pubmed.ncbi.nlm.nih.gov/8725999
https://pubmed.ncbi.nlm.nih.gov/8725999