Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Carol D. SanMartín"'
Autor:
Sebastián Oyarce-Pezoa, Guilherme Gischkow Rucatti, Francisco Muñoz-Carvajal, Nicole Sanhueza, Wileidy Gomez, Sandra Espinoza, Mario Leiva, Nicolás García, Daniela P. Ponce, Carol D. SanMartín, Diego Rojas-Rivera, Natalia Salvadores, Maria I. Behrens, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by protein accumulation in the brain as a main neuropathological hallmark. Among them, Aβ42 peptides tend to aggregate and create oligomers and plaques. M
Externí odkaz:
https://doaj.org/article/2ea3471a475747d3ac630b2c4a0a31ae
Autor:
Ismael Valdés-Undurraga, Pedro Lobos, Virginia Sánchez-Robledo, Alejandra Arias-Cavieres, Carol D. SanMartín, Genaro Barrientos, Jamileth More, Pablo Muñoz, Andrea Cristina Paula-Lima, Cecilia Hidalgo, Tatiana Adasme
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Introduction: Neuronal Ca2+ signals generated through the activation of Ca2+-induced Ca2+ release in response to activity-generated Ca2+ influx play a significant role in hippocampal synaptic plasticity, spatial learning, and memory. We and others ha
Externí odkaz:
https://doaj.org/article/2225fa91f74c48159a26b4005ba3f2ba
Autor:
Carol D. SanMartín, Felipe Salech, Daniela Paz Ponce, Jorge Concha-Cerda, Esteban Romero-Hernández, Gianella Liabeuf, Nicole K. Rogers, Paola Murgas, Bárbara Bruna, Jamileth More, María I. Behrens
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7364 (2023)
Epidemiological studies show that having a history of cancer protects from the development of Alzheimer’s Disease (AD), and vice versa, AD protects from cancer. The mechanism of this mutual protection is unknown. We have reported that the periphera
Externí odkaz:
https://doaj.org/article/7e3d1e748c8b43aca8e8e9cf0cbcbf02
Autor:
Yesid Cuesta-Astroz, Guilherme Gischkow Rucatti, Leandro Murgas, Carol D. SanMartín, Mario Sanhueza, Alberto J. M. Martin
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Gene Regulatory Networks (GRNs) allow the study of regulation of gene expression of whole genomes. Among the most relevant advantages of using networks to depict this key process, there is the visual representation of large amounts of information and
Externí odkaz:
https://doaj.org/article/4ec44de3a1544e3c88b2a2f82c1c1ba1
Autor:
Felipe Salech, Carol D. SanMartín, Jorge Concha-Cerda, Esteban Romero-Hernández, Daniela P. Ponce, Gianella Liabeuf, Nicole K. Rogers, Paola Murgas, Bárbara Bruna, Jamileth More, María I. Behrens
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9387 (2022)
Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesis. We hypothesize that cellular senescence markers might be tracked in the peripheral tissues of AD patients. Senescence hallmarks, including altere
Externí odkaz:
https://doaj.org/article/7fbe7e0435054b6a87698317d27d61c5
Autor:
Sandra Espinoza, Felipe Grunenwald, Wileidy Gomez, Felipe García, Lorena Abarzúa-Catalan, Sebastián Oyarce-Pezoa, Maria Fernanda Hernandez, Bastián I. Cortés, Markus Uhrig, Daniela P. Ponce, Claudia Durán-Aniotz, Claudio Hetz, Carol D. SanMartín, Victor H. Cornejo, Fernando Ezquer, Valentina Parra, Maria Isabel Behrens, Patricio A. Manque, Diego Rojas-Rivera, René L. Vidal, Ute Woehlbier, Melissa Nassif
Publikováno v:
Cells, Vol 11, Iss 12, p 1860 (2022)
Alzheimer’s disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon is a well-established inhi
Externí odkaz:
https://doaj.org/article/2c0619b110c14ca2bc7f93cba197acc2
Autor:
Felipe Salech, Daniela P. Ponce, Carol D. SanMartín, Nicole K. Rogers, Mauricio Henríquez, Maria I. Behrens
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
We have proposed that a common biological mechanism deregulated in opposite directions might explain the inverse epidemiological association observed between Alzheimer's disease (AD) and cancer. Accordingly, we showed that lymphocytes from AD patient
Externí odkaz:
https://doaj.org/article/cecbec8d20744d25a076c0f87268d038
Autor:
Felipe Salech, Daniela P. Ponce, Carol D. SanMartín, Nicole K. Rogers, Carlos Chacón, Mauricio Henríquez, Maria I. Behrens
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Mild cognitive impairment (MCI) is a clinically detectable initial stage of cognitive deterioration with a high conversion rate to dementia. There is increasing evidence that some of the cerebral alterations present in Alzheimer type dementia can be
Externí odkaz:
https://doaj.org/article/87a93969115c4dec94cd1394d54d5aa0
Autor:
Cecilia Hidalgo, Andrea C. Paula-Lima, Carol D. SanMartín, Pablo Veloso, Tatiana Adasme, Pedro Lobos, Barbara Bruna, Jose Galaz, Alejandra García, Steffen Hartel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low magnitude Ca2+ signals in neurons. We reported previously that these Ca2+ signals, which arise from Ca2+ entry and subseque
Externí odkaz:
https://doaj.org/article/59437070bb3f4eae9f44742532a49741
Autor:
Carol D. SanMartín, Andrea C. Paula-Lima, Alejandra eGarcía, Pablo eBarattini, Steffen eHartel, Marco T. Núñez, Cecilia eHidalgo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+-signals and promotes cytoplasmic generation of reac
Externí odkaz:
https://doaj.org/article/c1b4f8f81422413fb31b13a2dc0d233f