Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Carol D, Swartz"'
Autor:
Julie K. Buick, Andrew Williams, Rémi Gagné, Carol D. Swartz, Leslie Recio, Stephen S. Ferguson, Carole L. Yauk
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-14 (2020)
Abstract Background Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards and modes of action for chemical toxicology. In genetic toxicology, the
Externí odkaz:
https://doaj.org/article/7af746f5ce7d42ff8efd348882bc964e
Autor:
Julie K. Buick, Andrew Williams, Matthew J. Meier, Carol D. Swartz, Leslie Recio, Rémi Gagné, Stephen S. Ferguson, Bevin P. Engelward, Carole L. Yauk
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we combined the high-throughput alkaline DNA damage-sensing CometChip® assay with the TGx-DDI
Externí odkaz:
https://doaj.org/article/e4d39a8558a149fc9ffab87e469ad97d
Autor:
Stephanie L. Smith‐Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy, Jamie E. Sly, Xiaoqing Chang, Nisha S. Sipes, Keith R. Shockley, Shawn F. Harris, Sandra J. McBride, Gary J. Larson, Bradley J. Collins, Esra Mutlu, Kristine L. Witt
Publikováno v:
Environmental and Molecular Mutagenesis. 64:202-233
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd2947f3d2db52a359f6a1c16546e9bf
https://doi.org/10.1002/em.22534
https://doi.org/10.1002/em.22534
Autor:
Eunnara Cho, Carol D. Swartz, Andrew Williams, Miriam Rivas, Leslie Recio, Kristine L. Witt, Elizabeth K. Schmidt, Jeffry Yaplee, Thomas H. Smith, Phu Van, Fang Yin Lo, Charles C. Valentine, Jesse J. Salk, Francesco Marchetti, Stephanie L. Smith-Roe, Carole L. Yauk
Error-corrected Duplex Sequencing (DuplexSeq) enables direct quantification of low-frequency mutations and offers tremendous potential for chemical mutagenicity assessment. We investigated the utility of DuplexSeq to quantify induced mutation frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0297e7108e98c4ad7df2f12bf5adc5ad
https://doi.org/10.1101/2023.02.22.529418
https://doi.org/10.1101/2023.02.22.529418
Autor:
Andrew Williams, Julie K. Buick, Ivy Moffat, Carol D. Swartz, Leslie Recio, Daniel R. Hyduke, Heng-Hong Li, Albert J. Fornace Jr., Jiri Aubrecht, Carole L. Yauk
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 77-83 (2015)
Genotoxicity testing is a critical component of chemical assessment. The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the DNA damage response pathways involved in response, is be
Externí odkaz:
https://doaj.org/article/3ac0ae68f5b14cd4b1a579f3b97fd151
Autor:
Norah A, Owiti, Simran, Kaushal, Lincoln, Martin, Jamie, Sly, Carol D, Swartz, Jasmine, Fowler, Joshua J, Corrigan, Les, Recio, Bevin P, Engelward
Publikováno v:
Current Protocols. 2
Exposure to DNA damaging agents can lead to mutations that cause cancer. The liver is particularly vulnerable because it contains high levels of Cytochrome P450 enzymes that can convert xenobiotics into DNA reactive metabolites that form potentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6231d6520e79c91b248c4f32698cdaa9
https://doi.org/10.1002/cpz1.563
https://doi.org/10.1002/cpz1.563
Autor:
Eunnara Cho, Carol D. Swartz, Andrew Williams, Miriam Rivas, Leslie Recio, Kristine L. Witt, Elizabeth K. Schmidt, Jeffry Yaplee, Thomas H. Smith, Phu Van, Fang Yin Lo, Charles C. Valentine, Jesse J. Salk, Francesco Marchetti, Stephanie L. Smith-Roe, Carole L. Yauk
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :503649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0a524563e12aaae39a071bda2cdd3cc
https://doi.org/10.1016/j.mrgentox.2023.503649
https://doi.org/10.1016/j.mrgentox.2023.503649
Autor:
Andrew Williams, Rémi Gagné, Bevin P. Engelward, Leslie Recio, Carol D. Swartz, Matthew J. Meier, Carole L. Yauk, Julie K. Buick, Stephen S. Ferguson
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Frontiers in Public Health
Frontiers in Public Health
Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we combined the high-throughput alkaline DNA damage-sensing CometChip® assay with the TGx-DDI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0b04e9d82c6df1c49af6b008c036d9
https://doi.org/10.3389/fpubh.2021.694834
https://doi.org/10.3389/fpubh.2021.694834
Autor:
Carol D. Swartz, Steven M. Bryce, Kristine L. Witt, Scott S. Auerbach, Stephanie L. Smith-Roe, Grace E. Kissling, Stephen D. Dertinger, Kim G. Shepard, Suramya Waidyanatha
Publikováno v:
Environmental and Molecular Mutagenesis. 59:416-426
Black cohosh extract (BCE) is a widely used dietary supplement marketed to women to alleviate symptoms of gynecological ailments, yet its toxicity has not been well characterized. The National Toxicology Program (NTP) previously reported significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f33d894286f107dd0e9d666658221aa
https://doi.org/10.1002/em.22182
https://doi.org/10.1002/em.22182
Autor:
Carol D. Swartz, Shim-mo Hayashi, Leslie Recio, Cheryl A. Hobbs, Jeffrey Davis, Robert R. Maronpot, Mihoko Koyanagi, Sawako Kasamoto
Publikováno v:
Food and Chemical Toxicology. 113:218-227
Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as anti-oxidants; however, incorporation of natural quercetin glycosides into food and beverage pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac971075b84218956de9267529350f1
https://doi.org/10.1016/j.fct.2017.12.059
https://doi.org/10.1016/j.fct.2017.12.059