Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Carol Cho"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract ATAD2 is a non-canonical ATP-dependent histone chaperone and a major cancer target. Despite widespread efforts to design drugs targeting the ATAD2 bromodomain, little is known about the overall structural organization and regulation of ATAD2
Externí odkaz:
https://doaj.org/article/6a3339deb1de4a48a5ece3425a74ce57
Autor:
Carol Cho, Juwon Jang, Yujin Kang, Hiroki Watanabe, Takayuki Uchihashi, Seung Joong Kim, Koichi Kato, Ja Yil Lee, Ji-Joon Song
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
ATAD2 AAA+ ATPases are a family of histone chaperones that regulate nucleosome density and chromatin dynamics. Here, authors find that the fission yeast ATAD2 homolog Abo1 deposits histone H3–H4 onto DNA in an ATP-hydrolysis-dependent manner, and p
Externí odkaz:
https://doaj.org/article/566979fd3d954b63b376d18804509722
Autor:
Ji-Joon Song, Carol Cho
ATAD2 is a non-canonical ATP-dependent histone chaperone and a major cancer. Despite widespread efforts to design drugs targeting the ATAD2 bromodomain, little is known about the overall structural organization and AAA+ domains of ATAD2. Here, we pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::362858b1380ce4e4eb9874af64af4093
https://doi.org/10.1101/2022.10.10.511654
https://doi.org/10.1101/2022.10.10.511654
Publikováno v:
Molecules and Cells. 44:79-87
Chromatin dynamics is essential for maintaining genomic integrity and regulating gene expression. Conserved bromodomain-containing AAA+ ATPases play important roles in nucleosome organization as histone chaperones. Recently, the high-resolution cryo-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba7b25fefafa516231a27d44bad537e3
https://doi.org/10.14348/molcells.2021.2242
https://doi.org/10.14348/molcells.2021.2242
Publikováno v:
Biochemical and Biophysical Research Communications. 536:38-44
Aldehyde-alcohol dehydrogenase (AdhE) is a metabolic enzyme and virulence factor in bacteria. E. coli AdhE (eAdhE) multimerizes into spirosomes that are essential for enzymatic activity. However, it is unknown whether AdhE structure is conserved in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fced311f1fb7bc441e01af4f02e2b26
https://doi.org/10.1016/j.bbrc.2020.12.040
https://doi.org/10.1016/j.bbrc.2020.12.040
Publikováno v:
Nature Structural & Molecular Biology. 27:515-518
The second Keystone Symposium on AAA+ proteins, “AAA+ Proteins: From Atomic Structures to Organisms”, was held in Tahoe City, USA in January 2020. The program highlighted recent advances from structural, biochemical and cellular approaches that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4dd48b29a557d74bdab57fd19402051
https://doi.org/10.1038/s41594-020-0444-2
https://doi.org/10.1038/s41594-020-0444-2
Publikováno v:
Intensive Care Research, Vol 4, Iss 2, Pp 111-115 (2024)
Abstract Background The COVID-19 pandemic served as a reminder of the limited treatments available for acute respiratory distress syndrome (ARDS). The pandemic has highlighted the need to identify different clinical phenotypes of ARDS and investigate
Externí odkaz:
https://doaj.org/article/aa2e6e9d4db54459b37729f9a13fa950
Publikováno v:
Molecules and Cells
Chromatin dynamics is essential for maintaining genomic integrity and regulating gene expression. Conserved bromodomain-containing AAA+ ATPases play important roles in nucleosome organization as histone chaperones. Recently, the high-resolution cryo-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ffc24faeff205545d04794da86e5149
https://pubmed.ncbi.nlm.nih.gov/33658433
https://pubmed.ncbi.nlm.nih.gov/33658433
Autor:
Jane Namusoke, Kennedy Amone-P’Olak, Carol Chosen Nakanwagi, Henry Kibedi, Nathaniel Mayengo, Joseph Ssenyonga, Bernard Omech
Publikováno v:
Frontiers in Psychology, Vol 15 (2024)
ObjectiveAdverse childhood experiences (ACEs) are established risk factors for undesirable consequences in adolescence and early adulthood, including substance use and a lack of self-control. Based on the Social Bonds Theory (SBT), this study aims to
Externí odkaz:
https://doaj.org/article/500afe14bc1846488685bec95db21eaf
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Cytoplasmic dynein is a homodimeric microtubule (MT) motor protein responsible for most MT minus-end-directed motility. Dynein contains four AAA+ ATPases (AAA: ATPase associated with various cellular activities) per motor domain (AAA1-4). The main si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2320021311a3c66afde114a9fe9a33c1
https://doi.org/10.1073/pnas.1417422112
https://doi.org/10.1073/pnas.1417422112