Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Carol C. Pilbeam"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Osteoclasts induce chemotaxis of osteoblasts during bone remodelling, but maintain spatial segregation. Here the authors show that osteoclasts repel osteoblasts via contact inhibition of locomotion mediated by Semaphorin-Plexin signalling and develop
Externí odkaz:
https://doaj.org/article/69de27093323428796da9c3cdb7c342a
Autor:
John A. Taylor, Carol C. Pilbeam, Erika Abbott, Sambantham Shanmugam, Cassandra Trammel, Andrew Mikhalyuk, Dharamainder Choudhary, Benjamin L. Woolbright
Advanced bladder cancer remains a major source of mortality, with poor treatment options. Cisplatin-based chemotherapy is the standard treatment, however many patients are or become resistant. One potential cause of chemoresistance is the Warburg eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05b0ad0891763c17b1f22328a4dc4706
https://doi.org/10.1158/1535-7163.c.6538284.v1
https://doi.org/10.1158/1535-7163.c.6538284.v1
Autor:
John A. Taylor, Carol C. Pilbeam, Erika Abbott, Sambantham Shanmugam, Cassandra Trammel, Andrew Mikhalyuk, Dharamainder Choudhary, Benjamin L. Woolbright
Relative expression of HIF-1a and PPARa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c02c08af23dd0bd4f3d953f29cd31db
https://doi.org/10.1158/1535-7163.22506081.v1
https://doi.org/10.1158/1535-7163.22506081.v1
Autor:
John A. Taylor, Carol C. Pilbeam, Erika Abbott, Sambantham Shanmugam, Cassandra Trammel, Andrew Mikhalyuk, Dharamainder Choudhary, Benjamin L. Woolbright
Combination Index
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68e587b45c79729e3af1e0a2db21f1c
https://doi.org/10.1158/1535-7163.22506072.v1
https://doi.org/10.1158/1535-7163.22506072.v1
Autor:
Carol C. Pilbeam, Shilpa Choudhary
Publisher Summary This chapter focuses on the effects of prostaglandins (PG) and other eicosanoids on bone resorption and formation. Eicosanoids are oxygenated 20-carbon fatty acids derived from polyunsaturated eicosatrienoic, eicosatetranoic (arachi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2f7b2220dc84e47578b2a0428b88640
https://doi.org/10.1016/b978-0-12-814841-9.00051-8
https://doi.org/10.1016/b978-0-12-814841-9.00051-8
Autor:
Alexandra Goetjen, Augustus D. Mazzocca, Carol C. Pilbeam, Joseph A. Lorenzo, Sui-Pok Yee, Shilpa Choudhary, Elizabeth Santone, Douglas J. Adams, Mary Beth McCarthy
Publikováno v:
Endocrinology. 159:2759-2776
Increased bone resorption is considered to explain why intermittent PTH is anabolic for bone but continuous PTH is catabolic. However, when cyclooxygenase-2 (COX2) is absent in mice, continuous PTH becomes anabolic without decreased resorption. In mu
Publikováno v:
Prostaglandinsother lipid mediators. 148
Bladder cancer (BCa) is a common solid tumor marked by high rates of recurrence, especially in non-muscle invasive disease. Prostaglandin E2 (PGE2) is a ubiquitously present lipid mediator responsible for numerous physiological actions. Inhibition of
Autor:
Carol C. Pilbeam
Publikováno v:
Bone Regulators and Osteoporosis Therapy ISBN: 9783030573775
Prostaglandins (PGs) are highly bioactive fatty acids. PGs, especially prostaglandin E2 (PGE2), are abundantly produced by cells of both the bone-forming (osteoblast) lineage and the bone-resorbing (osteoclast) lineage. The inducible cyclooxygenase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80c0944b8b61ea48c6eb04809e8dd8d9
https://doi.org/10.1007/164_2019_332
https://doi.org/10.1007/164_2019_332
Publikováno v:
Bone. 85:123-130
Bone marrow macrophages (BMMs), in the presence of cyclooxygenase-2 (Cox2) produced PGE2, secrete an inhibitory factor in response to Rankl that blocks PTH-stimulated osteoblastic differentiation. This study was to determine if the inhibitory factor
Autor:
Dharamainder Choudhary, John A. Taylor, Sambantham Shanmugam, Carol C. Pilbeam, Benjamin L. Woolbright, Cassandra J Trammel, Erika Abbott, Andrew Mikhalyuk
Publikováno v:
Molecular cancer therapeutics. 17(9)
Advanced bladder cancer remains a major source of mortality, with poor treatment options. Cisplatin-based chemotherapy is the standard treatment, however many patients are or become resistant. One potential cause of chemoresistance is the Warburg eff