Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Carol C, Gregorio"'
Autor:
Catalina Vasilescu, Mert Colpan, Tiina H. Ojala, Tuula Manninen, Aino Mutka, Kaisa Ylänen, Otto Rahkonen, Tuija Poutanen, Laura Martelius, Reena Kumari, Helena Hinterding, Virginia Brilhante, Simo Ojanen, Pekka Lappalainen, Juha Koskenvuo, Christopher J. Carroll, Velia M. Fowler, Carol C. Gregorio, Anu Suomalainen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Familial cardiomyopathy in pediatric stages is a poorly understood presentation of heart disease in children that is attributed to pathogenic mutations. Through exome sequencing, we report a homozygous variant in tropomodulin 1 (TMOD1; c.565
Externí odkaz:
https://doaj.org/article/17f82ec28ec14b21ac18fe950a134c51
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011279 (2024)
The leiomodin (Lmod) family of actin-binding proteins play a critical role in muscle function, highlighted by the fact that mutations in all three family members (LMOD1-3) result in human myopathies. Mutations in the cardiac predominant isoform, LMOD
Externí odkaz:
https://doaj.org/article/d1c4262a10d6440d8adc1049377bcc5b
Autor:
Reiri Sono, Tania M. Larrinaga, Alden Huang, Frank Makhlouf, Xuedong Kang, Jonathan Su, Ryan Lau, Valerie A. Arboleda, Reshma Biniwale, Gregory A. Fishbein, Negar Khanlou, Ming-Sing Si, Gary M. Satou, Nancy Halnon, UCLA Congenital Heart Defects-BioCore Faculty, Glen S. Van Arsdell, Carol C. Gregorio, Stanly Nelson, Marlin Touma
Publikováno v:
Cells, Vol 12, Iss 11, p 1455 (2023)
As an essential component of the sarcomere, actin thin filament stems from the Z-disk extend toward the middle of the sarcomere and overlaps with myosin thick filaments. Elongation of the cardiac thin filament is essential for normal sarcomere matura
Externí odkaz:
https://doaj.org/article/1549951580934b4d81d7ef112d28c224
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Gregorio, Colpan and Iwanski characterize the role of cyclase-associated protein 2 (CAP2) in regulating the organization and dynamics of actin filaments within cardiomyocytes. They show that CAP2 depolymerizes and inhibits actin incorporation into th
Externí odkaz:
https://doaj.org/article/bde9cd3dca6f4dd298abb535d9836f9b
Autor:
Dmitri Tolkatchev, Garry E Smith, Lauren E Schultz, Mert Colpan, Gregory L Helms, John R Cort, Carol C Gregorio, Alla S Kostyukova
Publikováno v:
PLoS Biology, Vol 18, Iss 9, p e3000848 (2020)
Improper lengths of actin-thin filaments are associated with altered contractile activity and lethal myopathies. Leiomodin, a member of the tropomodulin family of proteins, is critical in thin filament assembly and maintenance; however, its role is u
Externí odkaz:
https://doaj.org/article/1cbcaa851ce94502ace6c68ed797cc37
Autor:
Lei Mi-Mi, Gerrie P Farman, Rachel M Mayfield, Joshua Strom, Miensheng Chu, Christopher T Pappas, Carol C Gregorio
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226138 (2020)
A novel cardiac-specific transgenic mouse model was generated to identify the physiological consequences of elongated thin filaments during post-natal development in the heart. Remarkably, increasing the expression levels in vivo of just one sarcomer
Externí odkaz:
https://doaj.org/article/2d90ecf9462448239a0553f27833ccd2
Autor:
Touma, Reiri Sono, Tania M. Larrinaga, Alden Huang, Frank Makhlouf, Xuedong Kang, Jonathan Su, Ryan Lau, Valerie A. Arboleda, Reshma Biniwale, Gregory A. Fishbein, Negar Khanlou, Ming-Sing Si, Gary M. Satou, Nancy Halnon, UCLA Congenital Heart Defects-BioCore Faculty UCLA Congenital Heart Defects-BioCore Faculty, Glen S. Van Arsdell, Carol C. Gregorio, Stanly Nelson, Marlin
Publikováno v:
Cells; Volume 12; Issue 11; Pages: 1455
As an essential component of the sarcomere, actin thin filament stems from the Z-disk extend toward the middle of the sarcomere and overlaps with myosin thick filaments. Elongation of the cardiac thin filament is essential for normal sarcomere matura
Autor:
Xin Sun, Swetansu K. Hota, Yu-Qing Zhou, Stefanie Novak, Dario Miguel-Perez, Danos Christodoulou, Christine E. Seidman, J. G. Seidman, Carol C. Gregorio, R. Mark Henkelman, Janet Rossant, Benoit G. Bruneau
Publikováno v:
Biology Open, Vol 7, Iss 1 (2018)
How chromatin-remodeling complexes modulate gene networks to control organ-specific properties is not well understood. For example, Baf60c (Smarcd3) encodes a cardiac-enriched subunit of the SWI/SNF-like BAF chromatin complex, but its role in heart d
Externí odkaz:
https://doaj.org/article/62d83786091c4b2c80877a1b569c4852
Publikováno v:
The FEBS Journal. 289:6119-6131
Leiomodin is an important emerging regulator of thin filaments. As novel molecular, cellular, animal model, and human data accumulate, the mechanisms of its action become clearer. Structural studies played a significant part in understanding the func
Autor:
Garry E. Smith, Dmitri Tolkatchev, Cristina Risi, Madison Little, Carol C. Gregorio, Vitold E. Galkin, Alla S. Kostyukova
Publikováno v:
Protein Science. 31