Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Carol Blau"'
Autor:
Peter J. Felock, Russell B. Lingham, Carol Blau, Chris M. Farnet, Daria J. Hazuda, Abigail Wolfe, Frederic D. Bushman, M. D. Williams, Jeffrey Hastings, Bernali Pramanik, Keith C. Silverman, Sheo B. Singh, Michael A. Goetz
Publikováno v:
Scopus-Elsevier
We have identified a series of novel inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase by randomly screening natural product extracts using an in vitro biochemical assay designed to identify inhibitors of integrase-catalysed strand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c30864f90dabed4558c2608d54a051
https://doi.org/10.1177/095632029901000202
https://doi.org/10.1177/095632029901000202
Autor:
Lori J. Gabryelski, Peter J. Felock, Daria J. Hazuda, Carol Blau, Jay A. Grobler, Abigail Wolfe, Michael D. Miller, Marc V. Witmer, William A. Schleif, Amy S. Espeseth, Kara A. Stillmock
Publikováno v:
Science (New York, N.Y.). 287(5453)
Integrase is essential for human immunodeficiency virus–type 1 (HIV-1) replication; however, potent inhibition of the isolated enzyme in biochemical assays has not readily translated into antiviral activity in a manner consistent with inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3e2451a39c36e9e49b9622565e10f9
https://pubmed.ncbi.nlm.nih.gov/10649997
https://pubmed.ncbi.nlm.nih.gov/10649997
Publikováno v:
Journal of virology. 70(3)
The integration of a DNA copy of the viral genome into the genome of the host cell is an essential step in the replication of all retroviruses. Integration requires two discrete biochemical reactions; specific processing of each viral long terminal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a658882998b82f6a76447265ff3531eb
https://pubmed.ncbi.nlm.nih.gov/8627659
https://pubmed.ncbi.nlm.nih.gov/8627659